Acute kidney injury

Reis, Thiago

doi:10.1590/1806-9282.66.s1.68

Cited by 7 publications

(9 citation statements)

References 16 publications

(22 reference statements)

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“…On the other hand, opposing evidence exists, suggesting that renal blood flow does not increase significantly after furosemide exposure actually ( 33 , 34 ). Moreover, furosemide may aggravate renal obstruction by promoting the aggregation of Tamm Horsfall protein in renal tubules, leading to AKI ( 35 , 36 ). It remains controversial whether AKI per se can be improved by furosemide or not in recent years ( 12 , 20 , 22 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children

Dai

Chen

et al. 2021

Front. Pediatr.

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Furosemide is commonly prescribed in critically ill patients to increase the urine output and prevent fluid overload (FO) and acute kidney injury (AKI), but not supported by conclusive evidence. There remain conflicting findings on whether furosemide associates with AKI and adverse outcomes. Information on the impact of furosemide on adverse outcomes in a general population of pediatric intensive care unit (PICU) is limited. The aim of the cohort study was to investigate the associations of furosemide with AKI and clinical outcomes in critically ill children.Study Design: We retrospectively reviewed a cohort of 456 critically ill children consecutively admitted to PICU from January to December 2016. The exposure of interest was the use of furosemide in the first week after admission. FO was defined as ≥5% of daily fluid accumulation, and mean FO was considered significant when mean daily fluid accumulation during the first week was ≥5%. The primary outcomes were AKI in the first week after admission and mortality during PICU stay. AKI diagnosis was based on Kidney Disease: Improving Global Outcomes criteria with both serum creatinine and urine output.Results: Furosemide exposure occurred in 43.4% of all patients (n = 456) and 49.3% of those who developed FO (n = 150) in the first week after admission. Patients who were exposed to furosemide had significantly less degree of mean daily fluid accumulation than those who were not (1.10 [−0.33 to 2.61%] vs. 2.00 [0.54–3.70%], P < 0.001). There was no difference in the occurrence of AKI between patients who did and did not receive furosemide (22 of 198 [11.1%] vs. 36 of 258 [14.0%], P = 0.397). The mortality rate was 15.4% (70 of 456), and death occurred more frequently among patients who received furosemide than among those who did not (21.7 vs. 10.5%, P = 0.002). Furosemide exposure was associated with increased odds for mortality in a multivariate logistic regression model adjusted for body weight, gender, illness severity assessed by PRISM III score, the presence of mean FO, and AKI stage [adjusted odds ratio (AOR) 1.95; 95%CI, 1.08–3.52; P = 0.026].Conclusion: Exposure to furosemide might be associated with increased risk for mortality, but not AKI, in critically ill children.

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Section: Discussionmentioning

confidence: 99%

Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children

Dai

Chen

et al. 2021

Front. Pediatr.

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“…In addition, the term was also approved in the Ibero-American Consensus on the Uniformity of Nomenclatures, observing the deliberations proposed by the Kidney Disease: Improving Global Outcomes (KDIGO) panel [1][2][3][4][5][6][7][8] . An additional advantage of using the term "injury" is that it encompasses initial cases with cellular and tissue functional alterations to cases of established anatomical lesions [9][10][11][12][13][14][15][16] . Therefore, it is suggested to avoid the term acute kidney lesion (AKL), which would be restricted to cases of anatomic kidney lesion.…”

Section: Acute Kidney Injury (Aki)mentioning

confidence: 99%

Acute kidney injury and renal replacement therapy: terminology standardization

et al. 2022

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The Department of Acute Kidney Injury (IRA) of the Brazilian Society of Nephrology prepared this document for the purpose of standardizing AKI terminology and dialysis modalities in the Portuguese language for Brazil. Several terms with similar meanings have been used in AKI and its dialysis modalities, causing confusion and disparities among patients, nephrologists, health institutions, private care companies, insurance companies and government entities. These disparities can impact medical care, hospital organization and care, as well as the funding and reimbursement of AKI-related procedures. Thus, consensual nomenclature and definitions were developed, including the definitions of AKI, acute kidney disease (AKD) and chronic kidney disease (CKD). Additionally, we addressed all dialysis modalities and extracorporeal procedures related to AKI, currently approved and available in the country. The Brazilian Society of Nephrology hopes that this Consensus can standardize the terminology and provide technical support to all involved in AKI care in Brazil.

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“…Além disso, o termo foi também aprovado no Consenso Ibero-Americano de Uniformização de Nomenclaturas, observando-se as deliberações propostas pelo painel Kidney Disease: Improving Global Outcomes (KDIGO) [1][2][3][4][5][6][7][8] . Uma vantagem adicional da utilização do termo "injúria" é que abrange desde os casos iniciais com alterações funcionais celular e tecidual até os casos de lesão anatômica estabelecida [9][10][11][12][13][14][15][16] . Por isso, sugere-se evitar o termo lesão renal aguda (LRA), que se restringiria aos casos de lesão anatômica renal.…”

Section: Injúria Renal Aguda (Ira)unclassified

Injúria renal aguda e métodos de suporte: padronização da nomenclatura

et al. 2022

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Resumo O Departamento de Injúria Renal Aguda (IRA) da Sociedade Brasileira de Nefrologia elaborou o presente documento para fins de padronização da terminologia em IRA e modalidades dialíticas na língua portuguesa para o Brasil. Diversos termos com significados semelhantes têm sido empregados em IRA e suas modalidades dialíticas, causando confusão e disparidades entre pacientes, nefrologistas, instituições de saúde, empresas privadas de assistência, seguradoras e entidades governamentais. Essas disparidades podem impactar a assistência médica, a organização e o atendimento hospitalares, assim como o financiamento e reembolso dos procedimentos relacionados com a IRA. Assim, nomenclatura e definições consensuais foram elaboradas, incluindo-se as definições de IRA, doença renal aguda (DRA) e doença renal crônica (DRC). Adicionalmente, todas as modalidades dialíticas e os procedimentos extracorpóreos relacionados a IRA, atualmente aprovados e disponíveis no país, foram abordados. A Sociedade Brasileira de Nefrologia espera que este Consenso possa padronizar a nomenclatura e prover suporte técnico para todos os atores envolvidos na assistência à IRA no Brasil.

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Acute kidney injury

Cited by 7 publications

References 16 publications

Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children

Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children

Acute kidney injury and renal replacement therapy: terminology standardization

Injúria renal aguda e métodos de suporte: padronização da nomenclatura

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