Acute kidney failure and acute pancreatitis was caused after neoadjuvant therapy for a patient with Breast Cancer：a case report

Abstract

Background: Acute kidney injury (AKI) is a common adverse reaction of platinum drugs in neoadjuvant chemotherapy for breast cancer patients. Approximately 30% of patients receiving cisplatin have acute kidney injury. Carboplatin have less nephrotoxic than cisplatin as the second generation platinum compound. There were AKI, nausea and vomiting, acute pancreatitis and oral ulcers occurred in a women who had intravenous carboplatin in our department.Case presentation: A 63 year-old Chinese female had neoadjuvant chemotherapy of TCbHP because of diagnosed with stage III breast invasive ductal carcinoma with axillary lymph node metastasis. Fourth day after chemotherapy, she had fatigue and nausea and then suffered from AKI, acute pancreatitis and mouth ulcers. After active treatment in the ICU and breast disease department, the patient's condition improved and was discharged.Conclusion: Although carboplatin, as a second-generation platinum drug, has less nephrotoxicity than cisplatin, it still needs special attention to avoid damage to the kidneys in clinical citation. At the same time, due to the killing effect of chemotherapeutics on the body's normal immune cells, other abnormal conditions in the body should be paid special attention to avoid more serious consequences.