Acute Isolated Hyperbilirubinemia as a Presentation of Alcoholic Liver Disease: A Case Report and Literature Review

Hossain, Muhammad Rajib; Pandey, Ramesh Kumar; Islam, Mohammad F.; Datar, Praveen; Gayam, Vijay; Puri, Pradeep; Thwin, Malar

doi:10.1155/2018/9403934

Cited by 5 publications

(2 citation statements)

References 13 publications

(13 reference statements)

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“…Hyperbilirubinemia in ALD is usually of unconjugated type, and conjugated hyperbilirubinemia is rare in ALD. In addition, the presentation of ALD with isolated hyperbilirubinemia and relatively normal aminotransferases is extremely rare with only a few reported cases [5][6][7]. A case series of intrahepatic cholestasis showed excellent recovery as compared to life-threatening presentations of ALD [8].…”

Section: Discussionmentioning

confidence: 99%

Direct/Conjugated Hyperbilirubinemia as an Uncommon Presentation of Acute Alcoholic Hepatitis: A Case Report

Abu-Abaa¹,

Kananeh²,

Mousa³

et al. 2023

Cureus

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Alcoholic liver disease (ALD) is a common pathology in clinical practice and is clinically diverse. Acute alcoholic hepatitis is an acute inflammation of the liver with or without underlying cholestasis and steatosis. In this case, we are presenting a 36-year-old male with a past medical history of alcohol use disorder who presented with two weeks of right upper quadrant abdominal pain and jaundice. However, direct/conjugated hyperbilirubinemia with relatively low aminotransferases in labs prompted investigation for obstructive and autoimmune hepatic pathologies. Unrevealing investigations prompted consideration of acute alcoholic hepatitis with cholestasis and a course of oral corticosteroids that gradually improved the patient's clinical symptoms and liver function test. This case helps to remind clinicians that although ALD is usually associated with indirect/unconjugated hyperbilirubinemia and elevated aminotransferases, presentation of ALD with mainly direct/conjugated hyperbilirubinemia with relatively low aminotransferases is a possibility. Although imaging tests should be pursued to rule out obstructive etiologies, invasive tests and liver biopsies are not indicated in typical clinical settings.

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Section: Discussionmentioning

confidence: 99%

Direct/Conjugated Hyperbilirubinemia as an Uncommon Presentation of Acute Alcoholic Hepatitis: A Case Report

Abu-Abaa¹,

Kananeh²,

Mousa³

et al. 2023

Cureus

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“…Isolated hyperbilirubinemia as a manifestation of alcoholic liver disease without significant liver abnormalities is rarely observed. Bilirubin may gradually decrease when alcohol consumption is stopped, [17]. Acetaldehyde, the result of alcohol metabolism causes liver fibrosis by the deposition of collagen fibers in liver cells.…”

Section: Discussionmentioning

confidence: 99%

Neoplastic Effects of Endogenous Alcohol in Carcinogenesis Process of Hepatocarcinoma

Udristioiu

Martin

et al. 2022

CLINICMED

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Introduction: Based on the grim statistics, the mortality of alcoholic liver disease was in last years the high in the undeveloped countries but and in developed countries in the statistic compared with last years. Aim: Scope of this work was to discover the patients diagnosed with alcoholic cirrhosis which in time was transformed in Hepatocellular Carcinoma, (HCT) by continue abuse alcohol and which presented, at a previous medical control, with the diagnosis of steatohepatitis after the chronic abuse of alcohol. Methodology: The retrospective study consisted of 180 patients, adult men (mean age 55 years) and females (mean age = 48) hospitalized and investigated for alcoholic liver diseases. From total cases investigated, 54 cases (30% from of cases admitted in hospital, meaning 27 men and 17 women), which were diagnosed with alcoholic liver cirrhosis in last 5-7 years but in next medical controls were discovered liver cancers in the 6.1% percent. Results: The majority of patients with uncompensated liver cirrhosis, (70%), have had elevated AST in average 66 U/L value, (N= 5-38U/L). Also, they have had an AST/ALT ratio 1.36, (N = 1.33) and ratio TGP/TGO = 0.95. In the liver carcinogenesis process the report AST/ALT increased in 2.64 value and ratio TGP/TGO decreased in 0.67 value. Conclusions: The active and rational lifestyle is an essential element in preventing the process of carcinogenesis. Liver disease it's not just how much you drink, but how and when you drink. The treatment of severe alcoholic hepatitis will be necessary in all alcoholic liver diseases centers to prevent hepatic cancer disease.

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Associations between per- and polyfluoroalkyl substances, liver function, and daily alcohol consumption in a sample of U.S. adults

Fisher

VoPham

et al. 2023

Environmental Research

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Acute Isolated Hyperbilirubinemia as a Presentation of Alcoholic Liver Disease: A Case Report and Literature Review

Cited by 5 publications

References 13 publications

Direct/Conjugated Hyperbilirubinemia as an Uncommon Presentation of Acute Alcoholic Hepatitis: A Case Report

Direct/Conjugated Hyperbilirubinemia as an Uncommon Presentation of Acute Alcoholic Hepatitis: A Case Report

Neoplastic Effects of Endogenous Alcohol in Carcinogenesis Process of Hepatocarcinoma

Associations between per- and polyfluoroalkyl substances, liver function, and daily alcohol consumption in a sample of U.S. adults

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