Acute Invasive Pulmonary Aspergillosis in Immunocompetent Host Without Underlying Lung Disease

Pulmonary Fungal Diseases in Immunocompetent Hosts: A Single-Center Retrospective Analysis of 35 Subjects

“…However, with the widespread use of broad-spectrum antibiotics, glucocorticoids, and chemotherapeutics, pulmonary fungal disease is no longer a rare event in immunocompetent patients [6], which have drawn increased attention since the 1990s. Cases have been reported in the USA, Spain, Germany, France, India, Korea, and Taiwan [7][8][9][10][11][12][13][14].…”

An unusual presentation of invasive aspergillosis with submandibular swelling in a 49‐year‐old man with end‐stage renal disease: A case report

“…7 On the other hand, IA may occur in immunocompetent hosts with no underlying lung disease such as extended ICU stay (>21 days), haemodialysis, liver cirrhosis, chronic obstructive pulmonary disease, burn injury, diabetes, malnutrition and influenza infection. 4,8 For the septic patient, often in the ICU, there is an explanation for susceptibility to aspergillosis that involves immunosuppression, induced by sepsis itself which was the case in our patient. 8 Our patient was a case of ESRD due to hypertensive nephropathy, whose initial presentation was fever complicated by sepsis and neutropenia.…”

“…3 Conditions that compromise the immune system predispose patients for IA and may result in high mortality rates. 4,5 IA can occur in a number of immunocompromised patients including bone marrow transplant recipients, with haematological malignancy, T-cell-depleted grafts, glucocorticoids and on immune suppressive drugs such as tyrosine kinase inhibitors. It can occur in AIDS patients, patients with primary immunodeficiency or those receiving immunosuppressive medications such as tumour necrosis factor-a blockers.…”