Acute Invasive Fungal Rhinosinusitis: Survival Analysis and the Prognostic Indicators

Göde, Sercan; Turhal, Göksel; Öztürk, Kerem; Aysel, Abdulhalim; Midilli, Raşit; Karci, Bulent

doi:10.2500/ajra.2015.29.4245

Cited by 24 publications

(53 citation statements)

References 29 publications

(52 reference statements)

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“…This may have been observed because patients with higher HbA1c% had a more reversible and treatable cause of immunosuppression (eg, hyperglycemia), but this warrants further investigation. CRP was not significantly correlated with survival, in contrast to other studies . However, only 16% of our patients had CRP data available for analysis.…”

Section: Discussioncontrasting

confidence: 97%

“…Timely diagnosis of AIFS is difficult because early clinical findings are nonspecific. Symptoms may include fever, nasal congestion, facial swelling, epistaxis, facial/nasal pain, rhinorrhea, or headache . Extensive disease can present with visual changes, cranial neuropathies, and necrosis .…”

mentioning

confidence: 99%

“…The cause of immunosuppression may play a role: acute mylogenous leukemia, renal failure, and diabetes have been associated with worse outcomes. Some studies reported that Mucor infections portend worse outcomes . Involvement of the hard palate, septum, ethmoid sinus, orbit, and brain may increase mortality.…”

mentioning

confidence: 99%

“…Some studies reported that Mucor infections portend worse outcomes . Involvement of the hard palate, septum, ethmoid sinus, orbit, and brain may increase mortality. Higher C‐reactive protein (CRP) levels have also been shown to be associated with a poor prognosis …”

mentioning

confidence: 99%

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A multi‐institutional review of outcomes in biopsy‐proven acute invasive fungal sinusitis

Wandell

Miller

Rathor

et al. 2018

Int Forum Allergy Rhinol

101

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Section: Discussioncontrasting

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A multi‐institutional review of outcomes in biopsy‐proven acute invasive fungal sinusitis

Wandell

Miller

Rathor

et al. 2018

Int Forum Allergy Rhinol

101

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“…Multiple series of invasive fungal sinusitis report mortality rates in excess of 50% in immunocompromised populations regardless of the cause of immune compromise [1, 2, 4, 6, 9, 27, 55, 71]. In our review of HIV-infected patients, the mortality was 80% and 73% in paranasal and mastoid sinus IA, respectively.…”

Section: Discussionmentioning

confidence: 75%

Invasive Aspergillus Sinusitis in Human Immunodeficiency Virus Infection: Case Report and Review of the Literature

Humphrey

Walsh

Gulick

2016

Open Forum Infectious Diseases

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Invasive Aspergillus (IA) sinusitis is a life-threatening opportunistic infection in immunocompromised individuals, but it is uncommon in human immunodeficiency virus (HIV) infection. To gain a better understanding of the characteristics of IA sinusitis in this population, we present a unique case of chronic IA sinusitis in an HIV-infected patient taking antiretroviral therapy and review the literature summarizing published cases of invasive aspergillosis of the paranasal (n = 41) and mastoid (n = 17) sinuses in HIV-infected individuals. Among these cases, only 4 were reported after 1999, and 98% of patients had acquired immune deficiency syndrome. Orbital invasion occurred in 54% of paranasal sinus cases, whereas intracranial invasion was reported in 53% of mastoid sinus cases. The overall mortality was 79%. We also discuss various clinical and immunologic factors that may play a role in the development of IA and consider the changing epidemiology of aspergillosis in the era of effective antiretroviral therapy.

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Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

Roland

Humphreys

et al. 2023

Int Forum Allergy Rhinol

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BackgroundAcute invasive fungal sinusitis (AIFS) is an aggressive disease that requires prompt diagnosis and multidisciplinary treatment given its rapid progression. However, there is currently no consensus on diagnosis, prognosis, and management strategies for AIFS, with multiple modalities routinely employed. The purpose of this multi‐institutional and multidisciplinary evidence‐based review with recommendations (EBRR) is to thoroughly review the literature on AIFS, summarize the existing evidence, and provide recommendations on the management of AIFS.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through January 2022. Studies evaluating management for orbital, non‐sinonasal head and neck, and intracranial manifestations of AIFS were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on management principles for AIFS were generated.ResultsA review and evaluation of published literature was performed on 12 topics surrounding AIFS (signs and symptoms, laboratory and microbiology diagnostics, endoscopy, imaging, pathology, surgery, medical therapy, management of extrasinus extension, reversing immunosuppression, and outcomes and survival). The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.

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Acute Invasive Fungal Rhinosinusitis: Survival Analysis and the Prognostic Indicators

Cited by 24 publications

References 29 publications

A multi‐institutional review of outcomes in biopsy‐proven acute invasive fungal sinusitis

A multi‐institutional review of outcomes in biopsy‐proven acute invasive fungal sinusitis

Invasive Aspergillus Sinusitis in Human Immunodeficiency Virus Infection: Case Report and Review of the Literature

Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

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