Acute invasive fungal rhinosinusitis: Molecular identification and update in management of frozen section biopsy

Shamsaei, Sina; Falahati, Mehraban; Farahyar, Shirin; Raiesi, Omid; Haghighi, Ladan; Farahani, Hamed Eraghiye; Akhavan, Asghar; Shamsaie, Alireza; Yarahmadi, Maryam; Keymaram, Mahyar

doi:10.1016/j.micpath.2021.105125

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Eventually, the products were run on a 2% agarose gel. The HWP1 gene amplification using the paired primers HWP1 –F (5′- GCTACCACTTCAGAATCATCATC-3′) and HWP1 -R (5′- GCACCTTCAGTCGTAGAGACG-3′) was done as described previously for Candida albicans complex [ 14 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia

Erami

Raiesi

Momen‐Heravi

et al. 2022

Microbial Pathogenesis

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Section: Methodsmentioning

confidence: 99%

Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia

Erami

Raiesi

Momen‐Heravi

et al. 2022

Microbial Pathogenesis

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“…The patient's condition progressed rapidly and critically after admission to the hospital, and after transfer to the ICU, although timely emergency surgery was performed to completely debride the necrotic tissues of the nasal septum and turbinate, but due to the complication of septic shock resulting in multiple organ failure, and the death of resuscitation was ineffective.AIFRS belongs to the invasive fungal rhinosinusitis. AIFRS is a form of invasive fungal sinusitis, which is characterized by intravascular in ammation of the local mucosa, thrombosis, mucosal granulation, ulcerative necrosis, and even necrosis of the bone tissue, and mycelium can be found in the mucosa or bone on pathologic sections.AIFRS is extremely rare, and is commonly seen in immunosuppressed patients with poorly controlled diabetes mellitus, and is extremely lethal, with a mortality rate of up to 50%-80% [3,4] . The diagnosis of AIFRS has not yet been standardized and includes the following: (1) radiographic evidence of sinusitis; (2) nasal endoscopy to con rm the presence of sinusitis; (3) histopathological con rmation of invasion of fungal hyphae into the nasal mucosa, submucosal layer, blood vessels, or bone tissues; (4) pathogenic microbiology; and (5) medical history as well as clinical manifestations [2] .…”

Section: Discussionmentioning

confidence: 99%

A case study of acute invasive fungal sinusitis complicating central retinal artery occlusion

Xiaodong,

Mei,

Kaijin

et al. 2024

Preprint

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Acute invasive fungal sinusitis is a fungal infectious disease in which fungal hyphae invade the nasal mucosa, blood vessels and nerves, causing tissue necrosis. Acute invasive fungal sinusitis is often complicated by intracranial infection, which is a critical disease with a high mortality rate. Meanwhile, ocular manifestations such as orbital cusp syndrome, cavernous sinus syndrome, and a sudden drop in visual acuity may suggest that the disease has been complicated by intracranial or intraorbital infection. Therefore, early diagnosis and early antifungal and anti-infectious treatment are essential to improve patient survival, and recognition of specific ocular signs is crucial for early diagnosis and treatment of acute invasive fungal sinusitis. In this article, we report a typical and rare case of acute invasive fungal sinusitis complicated by central retinal artery occlusion caused by Trichoderma infection. Central retinal artery occlusion is a kind of emergency and serious disease in ophthalmology, which has a rapid onset and rapid development. Failure to relieve the occlusion in time will result in permanent blindness of the patient, which will seriously affect the quality of life of the patient.Retinal artery obstruction relies heavily on imaging:Fundus Fluorescein Angiography: Demonstrates arterial and choroidal blood flow patterns to assess retinal blood flow and vascular obstruction. Patients present with very sluggish retinal arterial filling, and large areas of no perfusion;Optical Coherence Tomography : provides high-resolution images of retinal anatomy, thickness, and vitreoretinal interface in patients presenting with thickening of the inner retinal layer with edema and a highly reflective signal. Although the patient was treated by multidisciplinary diagnosis and treatment and transferred to the intensive care unit in a timely manner, he eventually died of systemic multi-organ failure due to complicated intracranial infection and sepsis. This case was discussed and analyzed from the ophthalmology point of view, and the relevant literature was reviewed in order to provide a reference for clinicians to recognize the initial symptoms of acute invasive fungal sinusitis, to provide timely antifungal and anti-infective treatment, to reduce missed diagnosis and misdiagnosis, and to avoid further deterioration of the patient's condition and death.In particular, we ophthalmologists are cautioned that retinal artery occlusion is not a purely ophthalmic disease, but is closely related to systemic diseases.

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“…This can be attributed partly to the rising prevalence of immunodeficiency, the emergence of COVID-19, and advancements in the diagnosis of pathogenic fungi. While Aspergillus and Mucorales are the primary agents of IFRS, other fungi such as Fusarium , Lomentospora, Curvularia, Alternaria, Cladosporium, Bipolaris, Exherosilum, Trichoderma, Schizophyllum, Candida , and Trichosporon are occasionally reported as well ( Ardeshirpour et al., 2014 ; Vinh et al., 2017 ; Shamsaei et al., 2021 ; Erami et al., 2023a ; Erami et al., 2023b ; Salah et al., 2023 ). However, the limited availability of diagnostic tools often results in delays in accurate detection and identification of invasive fungal pathogens, leading to delayed treatment.…”

Section: Discussionmentioning

confidence: 99%

“…(2018) described a case of IFRS resulting from F. riograndense (a newly identified species within the F. solani complex) infection in an 11-year-old boy with acute lymphoblastic leukemia, who was treated with voriconazole ( Dallé Rosa et al., 2018 ). Additionally, there are only two reported cases of IFRS caused by F. oxysporum , and no clinical details are available for these cases ( Shamsaei et al., 2021 ). Furthermore, there have been just four cases, including our current case 1, of IFRS caused by F. proliferatum with a presentation of rhinosinusitis.…”

Section: Discussionmentioning

confidence: 99%

Invasive Fusarium rhinosinusitis in COVID-19 patients: report of three cases with successful management

Erami,

Aboutalebian,

Hashemi Hezaveh

et al. 2023

Front. Cell. Infect. Microbiol.

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Invasive fungal rhinosinusitis (IFRS) is a life-threatening infection that can occur in immunocompromised patients, including those with COVID-19. Although Mucorales and Aspergillus species are the most common causes of IFRS, infections caused by other fungi such as Fusarium are rare. In this report, we present three cases of proven rhinosinusitis fusariosis that occurred during or after COVID-19 infection. The diagnosis was confirmed through microscopy, pathology, and culture, and species identification of the isolates was performed by DNA sequencing the entire ITS1-5.8 rRNA-ITS2 region and translation elongation factor 1-alpha (TEF-1α). Antifungal susceptibility testing was conducted according to CLSI guidelines. The causative agents were identified as Fusarium proliferatum, F. oxysporum + Aspergillus flavus, and F. solani/falciforme. Treatment involved the administration of antifungal medication and endoscopic sinus surgery to remove the affected mucosa, leading to the successful resolution of the infections. However, one patient experienced a recurrence of IFRS caused by A. flavus 15 months later. Early diagnosis and timely medical and surgical treatment are crucial in reducing mortality rates associated with invasive fusariosis. Additionally, the cautious use of corticosteroids in COVID-19 patients is highly recommended.

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Acute invasive fungal rhinosinusitis: Molecular identification and update in management of frozen section biopsy

Cited by 7 publications

References 21 publications

Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia

Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia

A case study of acute invasive fungal sinusitis complicating central retinal artery occlusion

Invasive Fusarium rhinosinusitis in COVID-19 patients: report of three cases with successful management

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