Acute Intravascular Hemolysis, Lower Nephron Nephrosis, and Acute Anterior Pituitary Necrosis Complicating a Case of Severe Pre-Eclampsia

The Pathogenesis of Post-Partum Necrosis of the Anterior Lobe of the Pituitary Gland

“…In previous papers (Sheehan 1937(Sheehan , 1948 accounts have been given of the mor¬ phological changes which are seen in post-partum necrosis of the anterior lobe of the pituitary gland during the first two weeks after its onset. The relevant literature was reviewed in those papers, but several further reports have been published since then (Louw 1947;Destro 1953;McKay et al 1953;Baker et al 1953;Pliess 1955;Vandervort et al 1955;Bardos 8c Pontuch 1956;Frangenheim 1956;Liebegott 1957;Mariuzzi 1958;Dyson 1959;Pascoe 8c McGuiness 1959;Tisne et al 1959;Wells et al 1960). The present paper is concerned essentially with the local vascular disturbances which give rise to the ischaemic necrosis, but as a necessary introduction two basic subjects will be considered first: the blood supply of the normal pituitary gland, and the significance of the parenchymal changes that are seen in the necrotic areas.…”