Acute interruption of treatment with nandrolone decanoate is not sufficient to reverse cardiac autonomic dysfunction and ventricular repolarization disturbances in rats

Marocolo, Moacir; Silva-Neto, Júlio Alves da; Neto, Octávio Barbosa

doi:10.1016/j.steroids.2018.01.005

Cited by 15 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have tried to identify a direct relationship with heart disorders by performing animal experiments and identifying autonomic dysfunction [ 70 , 71 ], fibrosis, hypertrophy, and myopathy [ 56 , 72 , 73 ], affecting ionic balance across the organ with a probable synergistic effect with other drugs [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

View full text Add to dashboard Cite

Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

show abstract

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this regard, the use of anabolic steroids is associated with the loss of the beneficial effects on left ventricle function induced by exercise [74]. Arrhythmic events following long-term administration of AASs were reported [68,[75][76][77][78]. Atrial fibrillation is the most frequent event but ventricular arrhythmias and sudden cardiac death were described in literature.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Adverse Effects of Anabolic-Androgenic Steroids: A Literature Review

et al. 2021

View full text Add to dashboard Cite

Anabolic-androgenic steroids (AASs) are a large group of molecules including endogenously produced androgens, such as testosterone, as well as synthetically manufactured derivatives. AAS use is widespread due to their ability to improve muscle growth for aesthetic purposes and athletes’ performance, minimizing androgenic effects. AAS use is very popular and 1–3% of US inhabitants have been estimated to be AAS users. However, AASs have side effects, involving all organs, tissues and body functions, especially long-term toxicity involving the cardiovascular system and the reproductive system, thereby, their abuse is considered a public health issue. The aim of the proposed review is to highlight the most recent evidence regarding the mechanisms of action of AASs and their unwanted effects on organs and lifestyle, as well as suggesting that AAS misuse and abuse lead to adverse effects in all body tissues and organs. Oxidative stress, apoptosis, and protein synthesis alteration are common mechanisms involved in AAS-related damage in the whole body. The cardiovascular system and the reproductive system are the most frequently involved apparatuses. Epidemiology as well as the molecular and pathological mechanisms involved in the neuropsychiatric side-effects of AAS abuse are still unclear, further research is needed in this field. In addition, diagnostically reliable tests for AAS abuse should be standardized. In this regard, to prevent the use of AASs, public health measures in all settings are crucial. These measures consist of improved knowledge among healthcare workers, proper doping screening tests, educational interventions, and updated legislation.

show abstract

“…In addition, discontinued usage did not result in an immediate return to normality. 303 In humans, anabolic steroids may be associated with a shortened QT interval, thus negatively impacting cardiac electrical activity. 304 In addition, indiscriminate use of anabolic steroids seems to be an independent risk factor for morbidity and premature death.…”

Section: Basic Life Support For Athletesmentioning

confidence: 99%