Acute intermittent porphyria

Syal, Kartik; Bhatt, Rashmi; Singh, Surinder; Ohri, Anil

doi:10.4103/0970-9185.155204

Cited by 1 publication

(2 citation statements)

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“…AIP attacks can be usually triggered due to different factors, including increase in cytochrome P450 expression that regulates ALAS activity due to drugs, and alcohol that also results in mood disorders, endocrine and metabolic disorders [3]. Menstruation is an important predisposing factor that we have observed among the patient under study.…”

Section: Discussionmentioning

confidence: 86%

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Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death

Xie¹,

Yan²

2015

J Blood Disord Transfus

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Acute intermittent porphyria (AIP) is a rare, frequently misdiagnosed disease characterized by abdominal pain and psychiatric symptoms. Abdominal pain is the most common. At present, there is no radical cure for AIP. Hematin is considering the effective treatment to relieve the symptom. However, it is not available in china. A 25-year-old Chinese woman complained about intermittent abdominal pain for 2 years. He was misdiagnosed as acute abdominal disease many times. During attacks, abdominal pain relief always took more than 1 week without effective treatment. In our hospital, the patient was diagnosed AIP definitely and treated with intravenous cimetidine 400mg Q6h, symptoms especially abdomen pain relieved within 48-72 hours completely in each acute attack. Few cases of cimetidine to treat AIP have been reported. More clinical date is required in order to verify whether the routine treatment of cimetidine can replace hematin or be used as a preventive treatment. This is the first case to report that cimetidine has obvious effect during AIP acute attacks.

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Section: Discussionmentioning

confidence: 86%

“…AIP is a rare autosomal dominant disorder with the incidence of affecting 1 to 2 in 10,000 [3]. The clinical manifestations of this syndrome are characterized by extreme variability with a severe abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death

Xie¹,

Yan²

2015

J Blood Disord Transfus

View full text Add to dashboard Cite

show abstract

Acute intermittent porphyria

Cited by 1 publication

References 5 publications

Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death

Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death

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