Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

Christiansen, Lasse Engbo; Urbin, M. A.; Mitchell, Gordon S.; Perez, Monica A.

doi:10.7554/elife.34304

Cited by 63 publications

(96 citation statements)

References 72 publications

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“…Our experimental approach assessed phrenic nerve output in anesthetized rats and may not be generalizable to respiratory control in freely behaving animals or to other forms of motor plasticity. However, AIH induces long-term facilitation of ventilation in humans (Mateika and Komnenov, 2017) and strengthens corticospinal pathways to non-respiratory motor-neurons (Christiansen et al, 2018), suggesting our results likely have relevance to mechanisms of human spinal motor plasticity after AIH. While AIH-induced respiratory motor plasticity does not necessarily alter normal homeostatic control of ventilation, the general facilitation of spinal motor output has significant therapeutic potential for treating patients with respiratory and non-respiratory motor limitations (Trumbower et al, 2012; Trumbower et al, 2017; Nichols et al, 2013; Hayes et al, 2014)…”

Section: Discussionmentioning

confidence: 61%

One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

Hocker

Beyeler

Gardner

et al. 2019

eLife

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Neonatal inflammation is common and has lasting consequences for adult health. We investigated the lasting effects of a single bout of neonatal inflammation on adult respiratory control in the form of respiratory motor plasticity induced by acute intermittent hypoxia, which likely compensates and stabilizes breathing during injury or disease and has significant therapeutic potential. Lipopolysaccharide-induced inflammation at postnatal day four induced lasting impairments in two distinct pathways to adult respiratory plasticity in male and female rats. Despite a lack of adult pro-inflammatory gene expression or alterations in glial morphology, one mechanistic pathway to plasticity was restored by acute, adult anti-inflammatory treatment, suggesting ongoing inflammatory signaling after neonatal inflammation. An alternative pathway to plasticity was not restored by anti-inflammatory treatment, but was evoked by exogenous adenosine receptor agonism, suggesting upstream impairment, likely astrocytic-dependent. Thus, the respiratory control network is vulnerable to early-life inflammation, limiting respiratory compensation to adult disease or injury.

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Section: Discussionmentioning

confidence: 61%

One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

Hocker

Beyeler

Gardner

et al. 2019

eLife

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“…2). In addition, evidence showed a similar augmentation in corticospinal excitability when PCMS was administered in combination with acute intermittent hypoxia, which is a noninvasive strategy known to increase corticospinal plasticity [10]. Taken together, these findings suggest that PCMS alone or in combination with other noninvasive therapeutic protocols can enhance the beneficial effects of sensorimotor rehabilitation after SCI.…”

Section: Stimulation Based On the Principles Of Stdpmentioning

confidence: 67%

Targeted-Plasticity in the Corticospinal Tract After Human Spinal Cord Injury

Christiansen

Perez

2018

Neurotherapeutics

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Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.

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“…In contrast, F-waves are readily obtained from intrinsic hand muscles and have previously been obtained to estimate changes in intrinsic excitability of the motoneuronal pool (see e.g. 88 ). However, the between-day reproducibility of the read-outs i.e.…”

Section: Changes Upstream and Downstream Of M1 Could Contribute To Thmentioning

confidence: 99%

Long-term motor skill training with individually adjusted progressive difficulty enhances learning and promotes corticospinal plasticity

Christiansen

Larsen

Madsen

et al. 2020

Sci Rep

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Motor skill acquisition depends on central nervous plasticity. However, behavioural determinants leading to long lasting corticospinal plasticity and motor expertise remain unexplored. Here we investigate behavioural and electrophysiological effects of individually tailored progressive practice during long-term motor skill training. Two groups of participants practiced a visuomotor task requiring precise control of the right digiti minimi for 6 weeks. One group trained with constant task difficulty, while the other group trained with progressively increasing task difficulty, i.e. continuously adjusted to their individual skill level. Compared to constant practice, progressive practice resulted in a two-fold greater performance at an advanced task level and associated increases in corticospinal excitability. Differences were maintained 8 days later, whereas both groups demonstrated equal retention 14 months later. We demonstrate that progressive practice enhances motor skill learning and promotes corticospinal plasticity. These findings underline the importance of continuously challenging patients and athletes to promote neural plasticity, skilled performance, and recovery.

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Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

Cited by 63 publications

References 72 publications

One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

Targeted-Plasticity in the Corticospinal Tract After Human Spinal Cord Injury

Long-term motor skill training with individually adjusted progressive difficulty enhances learning and promotes corticospinal plasticity

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