Acute Inpatient Rehabilitation: Utility of Psychosocial Classification to Provide Interventions and to Improve Rehabilitation Outcomes

Singh, SimerPreet; Poduri, Kanakadurga R.; Lee, Woojoong; Fleeman, Jennifer

doi:10.1016/j.pmrj.2013.08.139

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A possible explanation for the progressively decreasing cell viability in the HAp containing samples may be a slight cytotoxic effect of the extracts due to accumulation of scaffold degradation by‐products, caused by increased degradation rate induced by the addition of HAp. [ 40,41 ] However, in vivo, the constant circulation of physiological fluids could prevent the buildup of potentially cytotoxic compounds. This could become a major issue only in the case of scaffolds with very high degradation rates, such as 40/60 HAp/poPCL.…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that increasing the biomaterial surface on the micro-to nanoscale improves the cell adhesion and proliferation. [42,43] Proliferation of Saos-2 cells was analyzed after 1, 3, and 7 days after seeding. Cell proliferation for all samples was similar to the PS with a significant increase by day 7 (Figure 7C).…”

Section: Cell Adhesion and Proliferationmentioning

confidence: 99%

See 1 more Smart Citation

Development of Hot‐Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments

et al. 2021

View full text Add to dashboard Cite

The aim of this work is to develop a single‐step process to produce hydroxyapatite/polycaprolactone (HAp/PCL) composite filaments for 3D printing of bone scaffolds by fused deposition modeling (FDM). The HAp/PCL composite filaments are produced by hot‐melt extrusion, with direct in situ blending. For practical purposes, the effect of PCL particle size on filament homogeneity and printability is assessed between PCL in powder and pellet form. The effect of HAp content on processing parameters and filament properties is also evaluated. Filament extrudability, homogeneity, and shape consistency improve with increasing HAp content up to a threshold of 40 wt%. Furthermore, an optimal range of the composite melt viscosity for the extrusion process is defined. The produced filaments are successfully 3D printed by FDM and the resulting prototypes show improved compressive modulus and degradation rate with increasing HAp content. A cytocompatibility assay is conducted, which suggests an optimal HAp content to be less than 40 wt% in terms of cell viability, adhesion, and proliferation. The developed method offers several advantages, as it completely avoids the use of toxic solvents and enables the incorporation of very high HAp concentrations, further improving the chances of implementation of FDM for bone tissue regeneration medicine.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Cell Adhesion and Proliferationmentioning

confidence: 99%