Acute inhibition of dopamine β-hydroxylase attenuates behavioral responses to pups in adult virgin California mice (Peromyscus californicus)

Acosta, Melina C.; Tillage, Rachel P; Saltzman, Wendy

doi:10.1016/j.yhbeh.2021.105086

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Given that excessive grooming in the Dbh-/-mice appeared to be driven by DA, and we and others have reported that nepicastat increases tissue levels of DA in normal animals (Acosta et al, 2022;Devoto et al, 2015;Schroeder et al, 2010), it was puzzling that nepicastat did not increase grooming in Dbh+/-mice. To investigate potential neurochemical mechanisms, we assessed the effects of nepicastat on catecholamine levels.…”

Section: Pharmacological Blockade Of Ne Transmission Reduces Stress-i...mentioning

confidence: 88%

“…Mice were euthanized for trunk blood and brain tissue collection following exposure to either cage change or cage change + novel odorant, as previously described and delineated above (Acosta et al, 2022;Tillage et al, 2020a). Dorsal pons (containing LC) and PFC sections were rapidly dissected on ice and snap-frozen in isopentane on dry ice.…”

Section: Pons and Pfc Dissection And Hplc Detection Of Catecholamines...mentioning

confidence: 99%

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Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg

Liu²,

Iannitelli³

et al. 2022

Hormones and Behavior

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Section: Pharmacological Blockade Of Ne Transmission Reduces Stress-i...mentioning

confidence: 88%

Section: Pons and Pfc Dissection And Hplc Detection Of Catecholamines...mentioning

confidence: 99%

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg

Liu²,

Iannitelli³

et al. 2022

Hormones and Behavior

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Effects of acute inhibition of dopamine β-hydroxylase on neural responses to pups in adult virgin male California mice (Peromyscus californicus)

Acosta,

Hussein,

Saltzman

2024

Behavioural Brain Research

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Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg

Liu

Iannitelli

et al. 2022

Preprint

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Exposure to unfamiliar odorants induces an array of repetitive defensive and non-defensive behaviors in rodents which likely reflect adaptive stress responses to the uncertain valence of novel stimuli. Mice genetically deficient for dopamine beta-hydroxylase (Dbh-/-) lack the enzyme required to convert dopamine (DA) into norepinephrine (NE), resulting in globally undetectable NE and supranormal DA levels. Because catecholamines modulate novelty detection and reactivity, we investigated the effects of novel plant-derived odorants on repetitive behaviors in Dbh-/- mice and Dbh+/- littermate controls, which have catecholamine levels comparable to wild-type mice. Unlike Dbh+/- controls, which exhibited vigorous digging in response to novel odorants, Dbh-/- mice displayed excessive grooming. Drugs that block NE synthesis or neurotransmission suppressed odorant-induced digging in Dbh+/- mice, while a DA receptor antagonist attenuated grooming in Dbh-/- mice. The testing paradigm elicited high circulating levels of corticosterone regardless of Dbh genotype, indicating that NE is dispensable for this systemic stress response. Odorant exposure increased NE and DA abundance in the prefrontal cortex (PFC) of Dbh+/- mice, while Dbh-/- animals lacked NE and had elevated PFC DA levels that were unaffected by novel smells. Together, these findings suggest that novel odorant-induced increases in central NE tone contribute to repetitive digging and reflect psychological stress, while central DA signaling contributes to repetitive grooming. Further, we have established a simple method for repeated assessment of stress-induced repetitive behaviors in mice, which may be relevant for modeling neuropsychiatric disorders like Tourette syndrome or obsessive-compulsive disorder that are characterized by stress-induced exacerbation of compulsive symptoms.

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Acute inhibition of dopamine β-hydroxylase attenuates behavioral responses to pups in adult virgin California mice (Peromyscus californicus)

Cited by 3 publications

References 66 publications

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Effects of acute inhibition of dopamine β-hydroxylase on neural responses to pups in adult virgin male California mice (Peromyscus californicus)

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

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