Acute ingestions of boric acid

Linden, Christopher H.; Hall, Alan H.; Kulig, Kenneth; Rumack, Barry H.

doi:10.3109/15563658608992592

Cited by 64 publications

(32 citation statements)

References 13 publications

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“…29 The pharmacological properties of BA, including ease of handling, low toxicity, an almost complete clearance via urine within 24 hours and the fact that it is not metabolized make it an attractive cancer treatment candidate. 28,[35][36][37][38][39] To date, five published studies have focused on the potential of BA to control progression of cancer at the cellular level. 17,18,20,21,40 Of these, only one study examined the ability of BA to inhibit prostate cancer cell migration.…”

Section: Discussionmentioning

confidence: 99%

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (≤500 μM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 μM significantly inhibited cancer cell migration without effecting nontumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.

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Section: Discussionmentioning

confidence: 99%

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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“…None experienced serious toxicity, though four were dialyzed. It seems unlikely that an adult ingesting 3 g of sodium perborate monohydrate over two days would develop gastric perforation due to its borate component [19,21,22].…”

Section: Discussionmentioning

confidence: 99%

Ingestion of a denture cleanser: Did it cause gastric perforation?

Ingram

Baldwin

2008

J. Med. Toxicol.

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INTRODUCTIONEfferdent is a product designed to cleanse dentures in a container when added to water. The outside of the package clearly states in large, highlighted, capitalized letters: "Do not put tablets or solution directly in mouth." Despite this warning and similar ones found on other denture cleansing products, there were 1,512 reported exposures to denture cleanser products by the Toxic Exposure Surveillance System in 2005. Of these, 77% were in adults over 19 years old. Only 38 (2.5%) were intentional, 97.5% were accidental, 82 (5.4%) were treated in a healthcare facility, 8 (0.5%) were found to cause "moderate" complications, and only one resulted in death, though no further information is reported about this case [1]. CASE REPORTA 27-year-old man presented to an Emergency Department (ED) complaining of severe abdominal pain, diarrhea, and blood-tinged vomitus. Ten days prior the patient had been offered a job interview that required pre-employment urine drug testing. Because he had been smoking marijuana regularly, he followed a friend's suggestion to attempt manipulation of the cannabinoid assay through ingestion of Efferdent tablets. Seven days prior to presentation he ingested one tablet in a glass of water, which quickly resulted in abdominal pain. The following day he ingested two more tablets in water, which resulted in abdominal pain that continued to increase until presentation. He did not comment on whether the tablets were fully dissolved.The patient had no significant past medical or surgical history, took no medications, and had no allergies to medications. His family history was non-contributory. He denied any prior gastrointestinal symptoms. His social history was positive for tobacco abuse and negative for alcohol use.The patient's vital signs were: oral temperature, 36.1°C, heart rate 62 bpm, respiratory rate 18/minute, blood pressure 150/78 mmHg, and O 2 saturation 98% on room air. On physical examination, he was a thin male in moderate distress secondary to ABSTRACTIntroduction: Human ingestion of denture cleansers leading to gastric perforation has not previously been described. Case Report: A 27-year-old male ingested three denture cleanser tablets in water over two days in an attempt to cause a falsenegative result on a workplace urine drug screen. Seven days later he presented to an emergency department with a perforated gastric ulcer.Discussion: A literature review of cases and the chemistry of the components of his ingestion was conducted to determine the possible relationship between these events. Ingestion of intact fragments of the tablets would be likely to result in significant gastric toxicity, but ingestion of dissolved tablets would be unlikely to have caused his illness.

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“…Infants exhibiting adverse effects after ingestion of boric acid in infant formula had boron blood levels (reported as borate) of 20-150 μg/mL, with fatal cases having blood levels of 200-1,600 μg/mL (Wong et al 1964). Comparatively, adult serum boron level (as boric acid) of 2,320 μg/mL was not associated with significant toxicity (Linden et al 1986). …”

Section: Children's Susceptibilitymentioning

confidence: 99%

“…Boron concentrations, expressed as borate, reported in fatal cases vary from 200 to 1,600 μg/mL in infants (Wong et al 1964). In adults, a serum boron level (as boric acid) of 2,320 μg/mL was not associated with significant toxicity (Linden et al 1986). …”

Section: Biomarkers Used To Identify or Quantify Exposure To Boronmentioning

confidence: 99%

“…In the absence of body weight data, doses for these cases could not be estimated. The subjects were hospitalized for 24-96 hours and did not develop further symptoms following release (Linden et al 1986). Food poisoning of 13 children with unknown levels of aflatoxin and boric acid (Chao et al 1991a(Chao et al , 1991b Table 3-2 Oral a The number corresponds to entries in Figure 3-2.…”

Section: Systemic Effectsmentioning

confidence: 99%

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