“…BBB disruption (BBBD) causes seizures in animal models and human subjects [19, 45, 46, 48, 50, 51, 85]. In particular, a model of temporal lobe epilepsy (pilocarpine, PILO) also depends on BBBD [19, 51, 84]. The currently accepted mechanism of BBBD-induced seizures predicts activation of adhesion molecules on endothelial cells and leukocytes [19].…”