Acute idiopathic pancreatitis complicating active Crohn's disease: favorable response to infliximab treatment

Crohn's-associated chronic recurrent multifocal osteomyelitis responsive to infliximab

“…Improvement with infliximab has been reported with metastatic Crohn's disease and Crohn'sassociated spondyloarthropathy, pancreatitis, pulmonary disease, ocular disease (uveitis), and cutaneous disease (psoriasis, pyoderma gangrenosum, and hidradenitis suppurativa). [18][19][20][21][22][23][24][25][26][27][28] Many patients reported were refractory to other therapies, and some have required infliximab as maintenance for their extraintestinal manifestations. Infliximab has been shown to be efficacious for spondyloarthrpathies and in particular, ankylosing spondylitis in patients without a diagnosis of Crohn's disease.…”

Recurrent Pancreatitis, Rash, and Diarrhea: Crohn's Disease

“…7,10 Then again, as with our patient, pancreatitis also exists without duodenal involvement. 11,12 Our patient's case is unique in that the diagnosis of Crohn's disease came after multiple bouts of pancreatitis, circumstances reported in only a few other cases. 8,9 To our knowledge, this is also the first reported case of pancreatic panniculitis coinciding with pancreatitis and Crohn's disease.…”

“…Pancreatitis without an obvious cause has been diagnosed in patients with Crohn's disease, though an explanation for this relationship has yet to be identified. [4][5][6][7][8][9][10][11][12] The inflammatory process triggered in the walls of the proposed mechanism for this concurrence is that reflux of duodenal contents into the pancreatic duct activates zymogens. 7,10 Then again, as with our patient, pancreatitis also exists without duodenal involvement.…”

Pancréatite auto-immune

“…L'association avec une atteinte biliaire dans le cadre des maladies inflammatoires chroniques intestinales mériterait sûrem-ent d'être à nouveau étudiée car il est possible qu'un certain nombre de cas de cholangite sclérosante primitive soit en fait des cas de cholangite auto-immune comme décrite plus haut, c'est-à-dire corticosensibles. La pancréatite associée aux maladies inflammatoires chroniques intestinales peut elle-même répondre à la corticothérapie à l'instar des pancréatites chroniques auto-immunes [54] et un cas d'efficacité de l'infliximab a été publié [55]. Cette association entre maladies inflammatoires chroniques intestinales et pancréatite chronique auto-immune pose le problème « de la poule et de l'oeuf ».…”