Acute Idiopathic Blind Spot Enlargement

Fletcher, William A.; Imes, Richard K.; Goodman, Daniel F.; Hoyt, William F.

doi:10.1001/archopht.1988.01060130050026

Cited by 106 publications

(44 citation statements)

References 6 publications

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“…The MEWDS sometimes shows enlargement of the blind spot [10], and has been reported as being related to the acute idiopathic blind spot enlargement syndrome (AIBSE) [11, 12]. In our case, white dots were not detected in the MEWDS and fluorescein angiography did not show any lesion in the posterior area.…”

Section: Discussionsupporting

confidence: 44%

Optic Disk Vasculitis Associated with Chronic Active Epstein-Barr Virus Infection

Yamamoto¹,

Ohga

Ohnishi³

et al. 2002

Ophthalmologica

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Purpose: To report two cases of optic disk vasculitis associated with chronic active Epstein-Barr virus infection (CAEBV). Method: We examined the eyes of two patients with CAEBV. Results: In the first case, a 6-year-old boy, visual acuity was 20/20 in both eyes. Papillary and peripapillary exudates were observed in the right eye. Fluorescein angiography showed hyperfluorescence of the optic disk and a leakage from the peripapillary retinal vessels in the right eye. Two months later, the exudates increased and preretinal hemorrhages appeared in the right eye. Visual acuity decreased to 20/60. He was treated with systemic administration of corticosteroid, globulin and acyclovir. Visual acuity returned to 20/20, but peripapillary exudates remained in the right eye. In the second case, a 16-year-old girl, visual acuity was 20/20 in both eyes. The right eye showed optic disk swelling and dilated retinal veins. Fluorescein angiography showed hyperfluorescence of the optic disk but no leakage from the retinal vessels. Visual field examination revealed an enlarged blind spot in the right eye in both cases. These ocular manifestations are compatible with those of optic disk vasculitis, which shows swelling of the optic disk and dye leakage on and around the optic disk in fluorescein angiography, with an almost normal visual acuity and an enlargement of the blind spot. Conclusion: Persistent Epstein-Barr virus infection may cause optic disk vasculitis.

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Section: Discussionsupporting

confidence: 44%

Optic Disk Vasculitis Associated with Chronic Active Epstein-Barr Virus Infection

Yamamoto¹,

Ohga

Ohnishi³

et al. 2002

Ophthalmologica

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“…In 1988, Fletcher et al [8] described a syndrome of acuteidiopathic blind spot enlargement without obvious optic disk edema and retinal disorders in a series of 7 patients. Other cases were reported with similar clinical findings such as acute macular neuroretinopathy [9], MEWDS [10], multifocal choroiditis with panuveitis(MCP) [11,12,13,14] and punctate inner choroidopathy (PIC) [15].…”

Section: Discussionmentioning

confidence: 42%

Clinical Characteristics of Acute Zonal Occult Outer Retinopathy in Chinese Patients

Song

Sheng²,

Chen³

et al. 2008

Ophthalmologica

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Purpose: To review the clinical features of acute zonal occult outer retinopathy (AZOOR) in Chinese patients. Methods: All patients with AZOOR during 2002–2004 in our hospitals were reviewed retrospectively. Results: Seven consecutive Chinese patients with AZOOR were recruited and followed up for 4–18 months. Their age ranged from 26 to 47 years and all were affected bilaterally. They were from the cities near the Pacific Ocean and were used to eating seafood. The common complaints were slightly reduced visual acuity and photopsia. At least one eye of each patient had a visual field defect or decreased local area sensitivity and one patient had bilateral blind spot enlargement. Ten in 14 eyes showed increased numbers of vitreous cells and 4 eyes had anterior chamber inflammatory cells and a keratic precipitate. In their initial examination, minimal or no fundus changes were found, only yellow-white dots or gray dots presented on the deep retina or outer retinal layer. Fundus fluorescent angiography showed large-area depigmentation and hyperfluorescein spots corresponding to fundus findings. Electroretinogram (ERG) or multifocal ERG was abnormal in all eyes with no changes in their follow-up examination. Not all of the initial diagnoses of these patients were consistent with the final ones. Conclusions: AZOOR is not a common disease in China, but easy to misdiagnose. Female predilection, photopsia, visual field defect, ERG abnormality and minimal ophthalmoscopic changes are the common characteristics of AZOOR in Chinese patients. Living habits may play a role in the development of AZOOR.

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“…Because there was an arcuate segmental visual field defect connected to the blind spot, with no abnormalities in the ophthalmoscopic and fluorescein angiographic findings but with mfERG abnormalities in the areas of the visual field defect, we diagnosed our patient as having the AIBSE syndrome. Several authors [1, 2, 3, 4, 8] have suggested that the AIBSE syndrome belongs to a group of diseases including AZOOR, of which the primary pathological sites are photoreceptors. In support of this, in one study, time domain OCT showed a loss or irregularity of the IS/OS line in a patient with AZOOR, and the authors suggested that the primary lesion occurred in the photoreceptor outer segment [5].…”

Section: Discussionmentioning

confidence: 99%

“…The acute idiopathic blind spot enlargement (AIBSE) syndrome was first reported in 1988 by Fletcher et al [1] as a clinical entity with sudden scintillations and a temporal scotoma centered on the blind spot in an otherwise normal fundus. Later, AIBSE was reported to belong to a family of pathologically and etiologically related retinal diseases, including acute zonal occult outer retinopathy (AZOOR), acute macular neuroretinopathy, multiple evanescent white dot syndrome, multifocal choroiditis, and panuveitis, called the AZOOR complex [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Outer Retinal Microstructure in a Case of Acute Idiopathic Blind Spot Enlargement Syndrome

Sugahara

Shinoda

Matsumoto

et al. 2011

Case Rep Ophthalmol

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Purpose: To present a patient with acute idiopathic blind spot enlargement syndrome who had abnormal changes in the outer retinal microstructure limited to areas with reduced responses on multifocal electroretinograms as well as to the area involving a scotoma. Methods and Results: We report the case of a 44-year-old man who developed an arcuate scotoma which was associated with a physiological blind spot in the left eye. The ophthalmoscopic, fluorescein angiographic, and full-field electroretinogram findings were normal. The amplitudes of the multifocal electroretinograms were reduced in the area of the scotoma. Optical coherence tomography showed that both the external limiting membrane and the inner and outer segment (IS/OS) line were intact, but that the middle cone outer segment tip line between the IS/OS line and the retinal pigment epithelium was absent in the nasal macular area of the left eye. Conclusions: These findings indicate that the integrity of not only the external limiting membrane and IS/OS line but also the cone outer segment tip line is important for the function of the retina.

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Acute Idiopathic Blind Spot Enlargement

Cited by 106 publications

References 6 publications

Optic Disk Vasculitis Associated with Chronic Active Epstein-Barr Virus Infection

Optic Disk Vasculitis Associated with Chronic Active Epstein-Barr Virus Infection

Clinical Characteristics of Acute Zonal Occult Outer Retinopathy in Chinese Patients

Outer Retinal Microstructure in a Case of Acute Idiopathic Blind Spot Enlargement Syndrome

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