Acute hypoxic pulmonary hypertension associated with right heart failure

Kemdem, Arsène; Lovat, Robin; Siraux, V.; Dillien, Philippe; Dive, Florence

doi:10.1080/00015385.2019.1634333

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…The increase in LV afterload by an overload of pressure or volume is considered a determining cause of left heart failure (LHF). In contrast, pulmonary hypertension, pulmonary stenosis, chronic obstructive pulmonary disease, and tricuspid valve pathology produce similar consequences on the right side, inducing right heart failure (RHF) [ 100 – 102 ]. RHF could be acute or chronic.…”

Section: Distinctions Between Right and Left Ventricle Dysfunctionmentioning

confidence: 99%

“…RHF could be acute or chronic. Acute RHF is caused by a suddenly increased RV afterload due to hypoxia or a pulmonary embolus [ 102 , 103 ] or decreased RV contractility in RV ischemia, myocarditis, or postcardiotomy shock [ 104 ]. On the other hand, chronic RHF results from the gradual increases in RV afterload produced by pulmonary hypertension [ 101 , 102 ], which promotes cardiac remodeling with increased RV mass, fibrosis, and hypertrophy of cardiomyocytes, analogous to the remodeling observed in LHF [ 105 ].…”

Section: Distinctions Between Right and Left Ventricle Dysfunctionmentioning

confidence: 99%

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Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction

Bernal‐Ramírez

Díaz-Vesga

Talamilla

et al. 2021

Oxidative Medicine and Cellular Longevity

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The right and left ventricles have traditionally been studied as individual entities. Furthermore, modifications found in diseased left ventricles are assumed to influence on right ventricle alterations, but the connection is poorly understood. In this review, we describe the differences between ventricles under physiological and pathological conditions. Understanding the mechanisms that differentiate both ventricles would facilitate a more effective use of therapeutics and broaden our knowledge of right ventricle (RV) dysfunction. RV failure is the strongest predictor of mortality in pulmonary arterial hypertension, but at present, there are no definitive therapies directly targeting RV failure. We further explore the current state of drugs and molecules that improve RV failure in experimental therapeutics and clinical trials to treat pulmonary arterial hypertension and provide evidence of their potential benefits in heart failure.

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Section: Distinctions Between Right and Left Ventricle Dysfunctionmentioning

confidence: 99%

Section: Distinctions Between Right and Left Ventricle Dysfunctionmentioning

confidence: 99%

Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction

Bernal‐Ramírez

Díaz-Vesga

Talamilla

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Hypoxia causes vascular endothelial cell damage, which in turn perturbs the synthesis and secretion of various vasodilator factors and leads to pulmonary vasoconstriction in the short term and pulmonary vascular remodeling in the longer term (1). Such vascular remodeling is characterized by thickening of the medial membrane due to proliferation of phenotypically altered smooth muscle cells, and endothelial cell dysfunction not only leads to intimal thickening and distal pulmonary artery dilatation, but also inflammation and infiltration of the outer membrane (2).…”

Section: Introductionmentioning

confidence: 99%

Dysregulated lncRNA TUG1 in different pulmonary artery cells under hypoxia

Lv¹,

Jiang²,

Hu³

et al. 2021

Ann Transl Med

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Background: At present, the role of lncRNAs in the pathogenesis of hypoxia-induced pulmonary hypertension (HPH) is not fully understood. This study aimed to explore differences in the hypoxia-induced expression of lncRNAs and their potential role in multiple pulmonary artery cells. Methods: LncRNA expression in pulmonary artery smooth muscle cells (PASMCs), pulmonary microvascular endothelial cells (PMECs), and pericytes (PCs) was analyzed by high-throughput sequencing and compared between normoxic and hypoxic cells. Bioinformatics analysis was conducted to predict their functions. Results: PASMCs, PMECs, and PCs displayed 275 (140 upregulated), 251 (162 upregulated), and 290 (176 upregulated) different lncRNAs, respectively. Among these, lncRNA TUG1 levels increased in PASMCs and PCs but decreased in PMECs. Bioinformatics analysis indicated that lncRNA TUG1 might target miR-145-5p, thereby affecting SOX4 and BMF expression, and could also regulate miR-129-5p levels to affect CYP1B1 and VCP expression. It could also regulate miR-138-5p levels to affect KCNK3 and RHOC expression.Conclusions: Hypoxia exposure of vascular cells resulted in differential expression of lncRNAs, especially lncRNA TUG1, which showed significant abnormal expression in all three types of vascular cells under hypoxia. Our results suggested that abnormal expression of lncRNA TUG1 might be involved in the regulation of pulmonary vascular cell function under hypoxia.

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Acute hypoxic pulmonary hypertension associated with right heart failure

Cited by 2 publications

References 13 publications

Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction

Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction

Dysregulated lncRNA TUG1 in different pulmonary artery cells under hypoxia

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