Acute hypoxia and exercise improve insulin sensitivity (SI2*) in individuals with type 2 diabetes

Mackenzie, Richard W.A.; Watt, PW; Castle, Paige

doi:10.1002/dmrr.1156

Cited by 94 publications

(114 citation statements)

References 43 publications

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“…Other trial 12 demonstrated that IHE glucose tolerance enhancement four hours after exposure can be attributed to improvements in peripheral insulin sensitivity in sedentary males with T2D. Therefore, it may improve short-term glycaemic control [85].Similar to the effects of exercise, increased epinephrine during IHE, which was reported in healthy humans may have contributed to glycogen utilization via increases in cyclic adenosine monophosphate concentrations, potentially leading to post-treatment increased on insulin sensitivity [72].Similarly, it has been described that both IHE and IHT programmes carried out in hypoxic conditions increased glucose transporter GLUT-4 levels [33].Hypoxia and exercise have shown an additive effect on insulin sensitivity [87], suggesting that insulin signalling and insulin-dependent glucose transport, might have been up-regulated following hypoxic exercise [33, 34]. This additive improvement could also be attributed to an increase in the relative intensity of the practised exercise in hypoxia [56].…”

mentioning

confidence: 78%

“…An increase in body fat is linked with a decline in insulin sensitivity in both obese and elderly individuals, and a recent study showed that acute hypoxic training improved glucose tolerance, and that combined exercise in hypoxic state further ameliorated insulin sensitivity in T2D [87]. Other trial 12 demonstrated that IHE glucose tolerance enhancement four hours after exposure can be attributed to improvements in peripheral insulin sensitivity in sedentary males with T2D.…”

Section: Intermittent Hypoxia and Insulin Sensitivitymentioning

confidence: 99%

“…Hypoxia and exercise have shown an additive effect on insulin sensitivity [87], suggesting that insulin signalling and insulin-dependent glucose transport, might have been up-regulated following hypoxic exercise [33, 34]. This additive improvement could also be attributed to an increase in the relative intensity of the practised exercise in hypoxia [56].…”

Section: Intermittent Hypoxia and Insulin Sensitivitymentioning

confidence: 99%

“…This increased muscle uptake of glucose is accompanied by enhanced insulin sensitivity [11,131]. Likewise, it was reported that, in high altitude (2600m) the HbA1c decreased significantly in obese people four weeks after the altitude stay [84].An increase in body fat is linked with a decline in insulin sensitivity in both obese and elderly individuals, and a recent study showed that acute hypoxic training improved glucose tolerance, and that combined exercise in hypoxic state further ameliorated insulin sensitivity in T2D [87]. Other trial 12 demonstrated that IHE glucose tolerance enhancement four hours after exposure can be attributed to improvements in peripheral insulin sensitivity in sedentary males with T2D.…”

mentioning

confidence: 99%

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Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity

Urdampilleta¹,

González‐Muniesa

Portillo³

et al. 2011

J Physiol Biochem

104

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SummaryObesity is an important public health problem worldwide and is a major risk factor for a number of chronic diseases such as type 2 diabetes, adverse cardiovascular events and metabolic syndrome related features. Different treatments have been applied to tackle body fat accumulation and its associated clinical manifestations. Often, relevant weight loss is achieved during the first six months under different dietary treatments. From this point, a plateau is reached, and a gradual recovery of the lost weight may occur.Therefore, new research approaches are being investigated to assure weight maintenance.Pioneering investigations have reported that oxygen variations in organic systems may produce changes in body composition. Possible applications of intermittent hypoxia to promote health and in various pathophysiological states have been reported.The hypoxic stimulus in addition to diet and exercise can be an interesting approach to lose weight, by inducing higher basal noradrenalin levels and other metabolic changes whose mechanisms are still unclear. Indeed, hypoxic situations increase the diameter of arterioles, produce peripheral vasodilatation and decrease arterial blood pressure. Furthermore, hypoxic training increases the activity of glycolytic enzymes, enhancing the number of mitochondria and glucose transporter GLUT-4 levels as well as improving insulin sensitivity. Moreover, hypoxia increases blood serotonin, decreases leptin levels while appetite is suppressed. These observations allow considering the hypothesis that intermittent hypoxia induces fat loss and may ameliorate cardiovascular health, which might be of interest for the treatment of obesity. This new strategy may be useful and practical for clinical applications in obese patients.Key Words: obesity, body weight loss, intermittent hypoxia, treatment. 1. Obesity: Prevalence, causes and complicationsObesity is an important public health problem in most countries [63], which is characterized by an excess of body fat, when amounting values higher than 20% in men and 30% in adult women [20,66].The World Health Organization (2009) warns that there are over 400 million obese adults, and that the situation will worsen in the future.The main etiological factors causing excess body weight for height are assigned to overeating and low physical activity, which lead to a positive energy balance, and result in a body fat increase [91]. Furthermore, there are other causes such as the genetic component, the distribution of energy intake throughout the day, the dietary composition of macronutrients, sleep rest, endocrine disruptions or the individual ability to oxidize energy substrates [26,70,93]. Thus, obesity is a chronic multifactorial disease resulting from the interaction between genotype, environment and physical activity patterns [14,91,95].Obesity is considered one of the major risk factors in the onset of associated chronic diseases, such as hypercholesterolemia, type II diabetes (T2D), cardiovascular disorders and metabolic syndrome features [1...

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mentioning

confidence: 78%

Section: Intermittent Hypoxia and Insulin Sensitivitymentioning

confidence: 99%

Section: Intermittent Hypoxia and Insulin Sensitivitymentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity

Urdampilleta¹,

González‐Muniesa

Portillo³

et al. 2011

J Physiol Biochem

104

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show abstract

“…Hypoxia is a feature of chronic inflammatory diseases (e.g., cancer) [92], athletic performance and has been used therapeutically to improve the clinical outcomes of certain diseases [93][94][95]. Exposing tissues to stress, such as hypoxia, can lead to cell death that causes the release of DAMPs which are then able to bind to PRRs where they activate ILCs [92].…”

Section: Exercise and The Mobilization Of Ilcsmentioning

confidence: 99%

The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair

Jones¹,

Hoyne²

2017

J Clin Cell Immunol

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The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory T cells. In this review we examine the process of exercise induced muscle damage to provide comparisons of how this may follow a similar coordinated response as that mediated by toxin induced damage.

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Therapeutic Potential of Intermittent Hypoxia: Lessons from Respiratory Motor Plasticity

Navarrete‐Opazo

Dale²,

Mitchell

2014

Translational Research in Environmental and Occupational Stress

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Acute hypoxia and exercise improve insulin sensitivity (S_I²*) in individuals with type 2 diabetes

Cited by 94 publications

References 43 publications

Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity

Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity

The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair

Therapeutic Potential of Intermittent Hypoxia: Lessons from Respiratory Motor Plasticity

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