Acute Hypoxemic Respiratory Failure and ARDS

Lee, Warren L.; Slutsky, Arthur S.

doi:10.1016/b978-1-4557-3383-5.00100-7

Cited by 6 publications

(5 citation statements)

References 261 publications

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“…According to Lumb, this 60% emulsion will bring about 50 mL of oxygen per 100 mL on equilibration with 100% oxygen (conditions: atmospheric pressure) [ 28 ]. Moreover, it is assumed that perfluorooctyl bromide can dissolve four times more oxygen than CO 2 [ 29 ]. Therefore, in our study, PFC was applied as an oxygenating agent to potentially improve the properties of the designed dressings.…”

Section: Resultsmentioning

confidence: 99%

A Functionalized Membrane Layer as Part of a Dressing to Aid Wound Healing

Miłek¹,

Grzeczkowicz

Lipko

et al. 2022

Membranes

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Purpose: This study is an approach to a dressing platform based on support functionalized with oxygenating factors within an alginate layer, constituting a safe and even contact surface for interface with a wound. Methods: An alginate layer with incorporated oxygenating elements deposited on the support patch was assessed. As an oxygenating factor, perfluorooctyl was applied, and the layer coatings in two options, cross-linked and not, were evaluated. The function of human dermal fibroblast cells cultured in the presence of these constructs was analyzed, as well as their morphology using flow cytometry, fluorescence microscopy, and scanning electron microscopy. In addition, the membrane coating material was assessed using FTIR, AFM, and SEM-EDX characterization. Results: The applied membrane coatings adsorbed on the patch ensured the viability of the human fibroblasts cultured on the membranes during 10 days of culture. However, on the sixth day of culture, the percentage of live cells grown in the presence of cross-linked alginate with oxygenating factor ((ALG-PFC)net) was significantly higher than that of the cells cultured in the presence of the alginate coatings alone. SEM-EDX analysis of the (ALG-PFC)net confirmed the presence of oxygenating and cross-linking factors. In addition, the regular granular branched structure of the layer coating material involving the oxygenating and cross-linking factors was observed using the AFM technique. Conclusion: The topography of the layer coating material involving the oxygenating and cross-linking factors ensures an even contact surface for interface with the wound. Considering 5-day intervals between dressing replacements, the platform with an oxygenating configuration ensuring the growth and morphology of the human fibroblasts can be recommended at this time as an element of a dressing system.

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Section: Resultsmentioning

confidence: 99%

A Functionalized Membrane Layer as Part of a Dressing to Aid Wound Healing

Miłek¹,

Grzeczkowicz

Lipko

et al. 2022

Membranes

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“…15 However, PaO 2 is important because oxygen sensing systems respond to changes in PaO 2 . This definition does not address tissue oxygenation.…”

Section: Discussionmentioning

confidence: 99%

“…Because contribution of PaO2 to tissue oxygenation is low. 15 However, PaO 2 is important because oxygen sensing systems respond to changes in PaO 2 . 12,21 Hypoxemia is responsible for the symptoms like tachycardia, tremor, headache, or dyspnea.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] A PaO 2 of approximately 60 mmHg corresponds to an arterial oxygen saturation (SaO 2 ) level of 90%. Above this level there is no risk for hypoxic tissue injury.…”

Section: Introductionmentioning

confidence: 99%

“…Above this level there is no risk for hypoxic tissue injury. [12][13][14][15] A PaO 2 of approximately 60 mmHg corresponds to an arterial oxygen saturation (SaO 2 ) level of 90%. 11,12 However, many factors affect the relationship between SaO 2 and PaO 2 .…”

Section: Introductionmentioning

confidence: 99%

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