Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

Méndez-Guerrero, Antonio; Laespada-García, María Isabel; Gómez‐Grande, Adolfo; Ruiz-Ortiz, Mariano; Blanco-Palmero, Víctor Antonio; Azcárate-Díaz, Francisco Javier; Rábano-Suárez, Pablo; Álvarez-Torres, Eva; Hoz, Carlos de Fuenmayor-Fernández de Pablo la; Pérez, Diana Vega; Rodríguez-Montalbán, Raquel; Pérez‐Rivilla, Alfredo; Catalán, Javier; Ramos-González, Ana; Aleja, Jesús González de la

doi:10.1212/wnl.0000000000010282

Cited by 154 publications

(163 citation statements)

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“… Scullen T et al [ 178 ],reported a case of non-convulsive status epilepticus. Movement disorders 18 Generalized Myoclonus, Hypokinetic-rigid syndrome 2 Articles [ 182 ], [ 183 ] 4 3M 1F 71.25(58–88) CNS Vasculitis 19 CNS Vasculitis 2 Articles [ 98 ] [ 185 ], 2 NR in all articles. Cranial Nerve abnormalities 20 Anosmia 28 Articles [ 39 ], [ 56 ], [ 57 ], [ 58 ], [ 62 ], [ 69 ], [ 101 ], [ 182 ], [ 183 ], [ 198 ], [ 199 ], [ 200 ], [ 201 ], [ 202 ], [ 203 ], [ 204 ], [ 205 ], [ 206 ], [ 61 ], [ 207 ], [ 208 ], [ 209 ], [ 210 ], [ 211 ], [ 212 ], [ 213 ] [ 214 ], 3730 NR in all articles.…”

Section: Resultsmentioning

confidence: 99%

“…Seizure 20 Articles [39], [58], [60], [63], [101], [150], [166], [167], [168], [169], [170], [171], [172], [173], [174] (continued on next page) [56], [57], [58], [62], [69], [101], [182], [183], [198], [199], [200], [201], [202], [203], [204], [205], [206], [61], [207], [208], [209], [210], [211], [212] [56], [57], [58], [61], [62], [69], [200], [201] [203] [204], [205], [206],…”

Section: Seizure 17mentioning

confidence: 99%

“…After Immunotherapy, all 3 patients improved, at least partially. [182] Another study reported [183] a previously healthy 58-year-old man with COVID-19 who developed generalized myoclonus, fluctuating level of consciousness, opsoclonus, right-side dominant hypokineticrigid syndrome, and frank hypomimia. The patient also had brief conjugated, multidirectional, and chaotic saccadic ocular movements.…”

Section: ] Sotocamentioning

confidence: 99%

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Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

183

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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Section: Resultsmentioning

confidence: 99%

Section: Seizure 17mentioning

confidence: 99%

Section: ] Sotocamentioning

confidence: 99%

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Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

183

182

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“…7. A single case report of a patient who developed myoclonus and an acute but spontaneously reversible hypokinetic rigid syndrome, with DaTscan showing reduction of dopamine transporter uptake in the putamen as well as hyposmia 119 . 8.…”

Section: Hyposmia Is Well Documented In Covid-19 Patients Withoutmentioning

confidence: 99%

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

Sulzer

Antonini

Leta

et al. 2020

npj Parkinsons Dis.

145

165

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This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson's disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson's patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson's disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia.

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“…Although encephalitis has been described as a cardinal neurological manifestation of COVID-19 during the acute phase of illness [8,9], we have yet to encounter any of these associated movement disorder presentations. (In the time since this write-up was first prepared, patients with acute movement disorders and COVID-19 have been reported exiguously; we know of four such reports, which describe myoclonus [10,11], a hypokinetic-rigid syndrome [12], and tremor/ataxia [13]. Encephalitis was present in some of those patients.…”

Section: New Observations Lettermentioning

confidence: 99%