Abstract:Dengue fever is an acute mosquito-borne infection caused by dengue viruses belonging to the family Flaviviridae. It is an important public health problem in tropical and subtropical climates. Acute motor quadriparesis during the course of dengue infection is quite unusual and uncommonly reported. We hereby report two cases of acute motor quadriparesis during the course of dengue infection due to hypokalemia.
“…dengue-related neurological presentation had been reported due to dengue-induced myelitis [6], hypokalemia [7], Guillain-Barre syndrome [8][9][10] and dengue myositis [11]. In our case, we believe that her symptoms resulted from a combination of spinal cord oedema and haemorrhage causing cord compression with concomitant denguerelated encephalitis and transverse myelitis.…”
A 37-year-old woman presented with a short history of fever and bilateral lower limb weakness. She also had impaired sensory function up to T4 spine level and lax anal tone. Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite medical and surgical interventions, her lower limb weakness persists. A high index of suspicion is needed to recognise dengue-related neurological complications. This diagnosis should be considered in any patients from dengue endemic areas presenting with acute febrile illness with atypical neurological manifestations.
“…dengue-related neurological presentation had been reported due to dengue-induced myelitis [6], hypokalemia [7], Guillain-Barre syndrome [8][9][10] and dengue myositis [11]. In our case, we believe that her symptoms resulted from a combination of spinal cord oedema and haemorrhage causing cord compression with concomitant denguerelated encephalitis and transverse myelitis.…”
A 37-year-old woman presented with a short history of fever and bilateral lower limb weakness. She also had impaired sensory function up to T4 spine level and lax anal tone. Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite medical and surgical interventions, her lower limb weakness persists. A high index of suspicion is needed to recognise dengue-related neurological complications. This diagnosis should be considered in any patients from dengue endemic areas presenting with acute febrile illness with atypical neurological manifestations.
“…4 Other authors have also reported few cases of motor quadriparesis following hypokamia in dengue fever. 5,6,7 In a large study from India, it was observed that neurological manifestations of dengue fever were present in two major categories, encephalopathy and pure motor quadriparesis but the quadriparesis was majorly due to myositis in that study. 8 Differential diagnosis for acute onset quadriapresis include: Acute Gullain barre syndrome, Acute flaccid paralysis in early pahse of myelitis, compressive myelopathy in spinal shock and channelopathies.…”
Dengue is an important viral cause of febrile illness in tropical and subtropical regions. Manifestations may range from an asymptomatic infection to life threatening hemorrhagic fever and shock syndrome. Neurological presentations of this disease are rare. Here, we are presenting a case series of three confirmed cases of dengue fever with hypokalemic paralysis presenting as acute pure motor reversible quadriparesis. A clinician should keep dengue virus associated hypokalemic paralysis in mind while dealing with a case of fever with quadriparesis.
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