Acute hydrogen sulfide poisoning

Warenycia, Marcus W.; Goodwin, Lorne R.; Benishin, Christina G.; Reiffenstein, R. J.; Francom, Donna M.; Taylor, J. D.; Dieken, Fred P.

doi:10.1016/0006-2952(89)90288-8

Cited by 293 publications

(108 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many reports claim to measure "sulfide" in tissues [54][55][56][57] and serum or blood [47,[58][59][60] without mentioning that in fact they measured ALS. For example, Goodwin et al [55] determined sulfide in brain tissue by first binding the sulfide as zinc sulfide by addition of zinc acetate to the sample.…”

Section: Als and Dlsmentioning

confidence: 99%

See 1 more Smart Citation

Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices

Tangerman

2009

Journal of Chromatography B

222

198

View full text Add to dashboard Cite

Section: Als and Dlsmentioning

confidence: 99%

“…The ALS values in tissues (brain, liver, kidney, lung, heart, spleen [29,48,[54][55][56][57]62]) varied between 6.8 and 274.1 nmol/g (0.23-9.32 g/g). A large variation was seen between the outcome in the various reports (for a compilation see also Table 1 in [25]).…”

Section: Als and Dlsmentioning

confidence: 99%

Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices

Tangerman

2009

Journal of Chromatography B

222

198

View full text Add to dashboard Cite

“…Relatively high endogenous levels of H 2 S, which is well known toxic gas, have been found in the brains of rats, humans and bovine (1)(2)(3), suggesting that H 2 S may have a physiological function. Endogenous H 2 S in the brain is produced from L-cysteine by the pyridoxal 5Ј-phosphate-dependent enzyme, cystathionine ␤-synthase (CBS) 1 (4 -7).…”

mentioning

confidence: 99%

“…The enzymatic activity of CBS has two metabolic outcomes (2,18). In addition to the production of H 2 S CBS catalyzes the reaction with the substrate homocysteine to produce cystathionine (4,18).…”

mentioning

confidence: 99%

A Novel Enhancing Mechanism for Hydrogen Sulfide-producing Activity of Cystathionine β-Synthase

Eto

Kimura

2002

Journal of Biological Chemistry

View full text Add to dashboard Cite

H 2 S is produced from cysteine by cystathionine ␤-synthase (CBS) in the brain and functions as a neuromodulator. Although the production of H 2 S is regulated by Ca 2؉ and calmodulin in response to neuronal excitation, little is known about the molecular mechanism for the regulation in CBS activity. Here we show that four cysteine residues of CBS are involved in the regulation of its activity in the presence of Ca 2؉ and calmodulin. Sodium nitroprusside (SNP), a modifying agent for cysteine residues, enhances CBS activity, whereas N-ethylmaleimide, an alkylating agent for cysteine residues, completely abolished the effect of SNP. Site-directed mutagenesis of the 13 cysteine residues of CBS identified four cysteine residues that are involved in the regulation of CBS activity by SNP, and two of the four residues are involved in the regulation of the basal CBS activity. The enhancement of CBS activity by SNP is independent of nitric oxide production. In the presence of Staphylococcus aureus ␣-hemolysin, which permeabilizes the cell membrane, exogenously applied SNP enhances the activity of CBS in intact cells. The present study demonstrates a novel mechanism for the regulation of CBS activity and provides a possible therapeutic application of SNP for the diseases in which CBS activity is deficient.Relatively high endogenous levels of H 2 S, which is well known toxic gas, have been found in the brains of rats, humans and bovine (1-3), suggesting that H 2 S may have a physiological function. Endogenous H 2 S in the brain is produced from L-cysteine by the pyridoxal 5Ј-phosphate-dependent enzyme, cystathionine ␤-synthase (CBS) 1 (4 -7). CBS is expressed in the brain, and a CBS activator, S-adenosylmethionine (AdoMet), enhances H 2 S production (6). These observations, together with our recent finding that endogenous H 2 S is under detectable levels in the brains of CBS knock-out mice, indicate that CBS is a major H 2 S-producing enzyme in the brain (7).The production of H 2 S is regulated by a Ca 2ϩ -and calmodulin-mediated pathway that is activated in response to neuronal excitation (7). Physiological concentrations of H 2 S specifically potentiate the activity of the N-methyl-D-aspartate (NMDA) receptor, and hippocampal long term potentiation is altered in CBS knock-out mice (6, 7). H 2 S can regulate the release of corticotropin-releasing hormone from the hypothalamus (8). In addition to the function in the brain H 2 S relaxes smooth muscle in synergy with nitric oxide (NO) by activating ATP-dependent potassium channels (9, 10). Based upon these observations it has been proposed that H 2 S may function as a neuromodulator, as well as a smooth muscle relaxant (6, 9).Sodium nitroprusside (SNP), which is well known as an NO donor, activates guanylyl cyclase and relaxes smooth muscle (11,12). SNP has also been used to detect cysteine, cystine, acetophenone, and sulfite in a reaction known as the Legal and Boedeker reaction, as well as secondary amines (13-15). The reactivity of SNP on cysteine residues modifies biolog...

show abstract

“…[80][81][82][83] Consequently, the reported biologically relevant concentrations of H 2 S vary over a 10 5 -fold range, from 100 pM to 300 mM. 81,[84][85][86][87][88] Recent reports described several small-molecule fluorescent probes for H 2 S detection in living systems. [89][90][91][92][93][94] All these designs are based on H 2 S-specific reactions.…”

Section: Hydrogen Sulfide (H 2 S) Sensorsmentioning

confidence: 99%

Expanding the chemistry of fluorescent protein biosensors through genetic incorporation of unnatural amino acids

Niu

Guo

2013

Mol. BioSyst.

View full text Add to dashboard Cite

Acute hydrogen sulfide poisoning

Cited by 293 publications

References 27 publications

Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices

Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices

A Novel Enhancing Mechanism for Hydrogen Sulfide-producing Activity of Cystathionine β-Synthase

Expanding the chemistry of fluorescent protein biosensors through genetic incorporation of unnatural amino acids

Contact Info

Product

Resources

About