Acute hydrogen sulfide-induced neurochemical and morphological changes in the brainstem

Maldonado, Cristina M Santana; Kim, Dong-Suk; Purnell, Benton S.; Li, Rui; Buchanan, Gordon F.; Smith, Jodi D.; Thedens, Daniel R.; Gauger, Phillip C.; Rumbeiha, Wilson K.

doi:10.1016/j.tox.2023.153424

Cited by 8 publications

(41 citation statements)

References 69 publications

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“…H 2 S and NH 3 have adverse effects on human health, impacting the cardiovascular, respiratory, and central nervous systems [28]. Their presence can cause chronic cough, asthma, throat and eye irritation, as well as phlegm discharge [14], chronic exposure to H2S gas can lead to respiratory disturbances, coughing, and this gas is not classified as carcinogenic [29] while NH3 causes irritation to the respiratory tract, nose, throat, and eyes [30].…”

Section: Discussionmentioning

confidence: 99%

Risk Analysis H2S And NH3 Exposure to Local Community Around Benowo Landfill Surabaya

Imandini,

Khambali,

Ngadino

et al. 2023

International Journal of Advanced Health Science and Technology

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Final waste processing in Indonesia adopts a landfill system. The Benowo landfill employs this system, which has a weakness in producing H2S and NH3 gases. The objective of this study was to assess the level of public health risk present in the Benowo landfill environment. The study design used was quantitative descriptive with a cross-sectional approach. The sample size consisted of 93 housewives selected using simple random sampling techniques, and gas measurements were conducted at two locations. The data analysis methods employed were univariate analysis and ARKL. The findings of this research demonstrated that the level of hydrogen sulfide (H2S) gas measured 0.02 ppm, while the concentration of ammonia (NH3) was 0.006 ppm. which were still below the quality standards set by East Java Governor Regulation No. 10 year 2009 regarding ambient air quality standards and stationary source emissions in East Java, where the limits for H2S were 0.03 ppm and NH3 were 2.00 ppm. The response dose value (Rfc) for H2S was 0.002 mg/m3, and for NH3 it was 0.5 mg/m3. The RQ value for H2S was greater than 1, indicating a potential risk, while the RQ value for NH3 was less than or equal to 1, indicating safety for the community. H2S gas poses a risk, whereas NH3 does not pose a risk to the communities in the Benowo landfill environment. It is recommended that individuals have a healthy lifestyle, and wear masks in the Benowo landfill environment and local government should be able to carry out the risk management through related agencies to the people lived near Benowo landfill area.

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Section: Discussionmentioning

confidence: 99%

Risk Analysis H2S And NH3 Exposure to Local Community Around Benowo Landfill Surabaya

Imandini,

Khambali,

Ngadino

et al. 2023

International Journal of Advanced Health Science and Technology

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Section: Methodsmentioning

confidence: 99%

“…For the acute study, we followed our previously published LCt 50 model [ 3 , 5 , 6 , 7 , 8 , 9 , 12 , 13 ] ( Figure 1 A). Briefly, two cohorts of male mice ( n = 10) were exposed to 1000 ppm of H 2 S for 45 min using a whole-body inhalation exposure chamber, as reported previously [ 3 , 5 , 6 , 7 , 8 , 9 , 12 , 13 ]. This level and length of exposure results in 50% mortality (lethal concentration time 50 [LCt 50 ]) during exposure, and mice typically exhibit dyspnea, convulsions, loss of consciousness, and death in that order [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…Endogenously produced H 2 S plays key roles in brain signaling and is essential for normal brain physiologic functions. However, excessive amounts of H 2 S in the brain, either from aberrant endogenous metabolic pathways (genetic defects) or environmental exposures, leads to neuronal dysfunction, including neurodegeneration [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Ethylmalonic encephalopathy (OMIM 602473), a life-limiting disease, is caused by a genetic defect in H 2 S metabolism in mitochondria, resulting in chronic excessive H 2 S exposure in the brain [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…We postulated that metabolic signatures of the brainstem could be observed in an inhalation whole-mouse model because human exposure to H 2 S gas is typically via inhalation. For this project, we focused on the brainstem because this region has been previously shown to undergo neurodegeneration following acute H 2 S exposure and also because it controls vital autonomic functions such as breathing [ 3 ]. Impaired breathing is widely implicated as a cause of death following acute H 2 S poisoning [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Metabolomic Signatures of Brainstem in Mice following Acute and Subchronic Hydrogen Sulfide Exposure

Kim,

Santana Maldonado,

Giulivi

et al. 2024

Metabolites

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Hydrogen sulfide (H2S) is an environmental toxicant of significant health concern. The brain is a major target in acute H2S poisoning. This study was conducted to test the hypothesis that acute and subchronic ambient H2S exposures alter the brain metabolome. Male 7–8-week-old C57BL/6J mice were exposed by whole-body inhalation to 1000 ppm H2S for 45 min and euthanized at 5 min or 72 h for acute exposure. For subchronic study, mice were exposed to 5 ppm H2S 2 h/day, 5 days/week for 5 weeks. Control mice were exposed to room air. The brainstem was removed for metabolomic analysis. Enrichment analysis showed that the metabolomic profiles in acute and subchronic H2S exposures matched with those of cerebral spinal fluid from patients with seizures or Alzheimer’s disease. Acute H2S exposure decreased excitatory neurotransmitters, aspartate, and glutamate, while the inhibitory neurotransmitter, serotonin, was increased. Branched-chain amino acids and glucose were increased by acute H2S exposure. Subchronic H2S exposure within OSHA guidelines surprisingly decreased serotonin concentration. In subchronic H2S exposure, glucose was decreased, while polyunsaturated fatty acids, inosine, and hypoxanthine were increased. Collectively, these results provide important mechanistic clues for acute and subchronic ambient H2S poisoning and show that H2S alters brainstem metabolome.

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Role of hydrogen sulfide in health and disease

Jin,

Yuan,

Liu

et al. 2024

MedComm

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In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter. In mammals, H2S‐catalyzing enzymes, such as cystathionine‐β‐synthase, cystathionine‐γ‐lyase, and 3‐mercaptopyruvate sulfurtransferase, are differentially expressed in a variety of tissues and affect a variety of biological functions, such as transcriptional and posttranslational modification of genes, activation of signaling pathways in the cell, and metabolic processes in tissues, by producing H2S. Various preclinical studies have shown that H2S affects physiological and pathological processes in the body. However, a detailed systematic summary of these roles in health and disease is lacking. Therefore, this review provides a thorough overview of the physiological roles of H2S in different systems and the diseases associated with disorders of H2S metabolism, such as ischemia–reperfusion injury, hypertension, neurodegenerative diseases, inflammatory bowel disease, and cancer. Meanwhile, this paper also introduces H2S donors and novel release modes, as well as the latest preclinical experimental results, aiming to provide researchers with new ideas to discover new diagnostic targets and therapeutic options.

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Acute hydrogen sulfide-induced neurochemical and morphological changes in the brainstem

Cited by 8 publications

References 69 publications

Risk Analysis H2S And NH3 Exposure to Local Community Around Benowo Landfill Surabaya

Risk Analysis H2S And NH3 Exposure to Local Community Around Benowo Landfill Surabaya

Metabolomic Signatures of Brainstem in Mice following Acute and Subchronic Hydrogen Sulfide Exposure

Role of hydrogen sulfide in health and disease

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