Acute Human Inkoo and Chatanga Virus Infections, Finland

Putkuri, Niina; Levanov, Lev; Kivistö, Ilkka; Brummer-Korvenkontio, M; Vaheri, Antti; Vapalahti, Olli

doi:10.3201/eid2205.151015

Cited by 40 publications

(33 citation statements)

References 19 publications

(17 reference statements)

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“…ACHOV was isolated from mosquitoes in Panama [14], MELV in Trinidad and Brazil [13,51], and SDNV in Brazil [52]. INKV and CHATV are primarily found in Scandinavia and Russia [53,54,55,56], while TAHV is found throughout Europe, Russia, Asia, and Africa [53,57,58,59,60,61,62]. LUMV is the only CSG member found, thus far, exclusively in Africa [12,61].…”

Section: Geographic Distributionmentioning

confidence: 99%

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Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

Evans

Peterson

2019

Viruses

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The California serogroup (CSG) comprises 18 serologically and genetically related mosquito-borne orthobunyaviruses. Of these viruses, at least seven have been shown to cause neurological disease in humans, including the leading cause of pediatric arboviral encephalitis in the USA, La Crosse virus. Despite the disease burden from these viruses, much is still unknown about the CSG viruses. This review summarizes our current knowledge of the CSG viruses, including human disease and the mechanisms of neuropathogenesis.

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Section: Geographic Distributionmentioning

confidence: 99%

“…Of the 18 CSG viruses, eight have caused confirmed human disease (Figure 1). CEV, LACV, SSHV, JCV, TAHV, INKV, and CHATV have been shown to cause neuroinvasive disease [1,55,84,151,152,153]. KEYV was associated with one case of febrile illness and diffuse rash without CNS involvement [146].…”

Section: Human Infection and Diseasementioning

confidence: 99%

Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

Evans

Peterson

2019

Viruses

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“…This trend is predicted to continue in forthcoming years (European Centre for Disease Prevention and Control, ), and has the potential to result in the ranges of many native and invasive species being altered. This increases the need to know where mosquito species are distributed, as a warming climate will also expand the ranges for mosquito‐borne arboviruses that affect humans, several of which are known from Finland, including but not limited to Sindbis virus (Sane et al ., ), Inkoo virus (Brummer‐Korvenkontio et al ., ; Putkuri et al ., ) and Chatanga virus (Putkuri et al ., ).…”

Section: Introductionmentioning

confidence: 99%

A report on the mosquitoes of mainland Åland, southwestern Finland and revised list of Finnish mosquitoes

Culverwell

2017

Medical Vet Entomology

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To successfully implement surveillance or control strategies for mosquitoes, up-to-date knowledge of regional species composition is vital. The last report regarding mosquitoes (Diptera: Culicidae) in the Åland archipelago, southwestern Finland listed 19 species (Utrio, 1979). To determine the current species diversity, one collection trip was made to mainland Åland in 2015 and three in 2016. Mosquitoes (n = 3286) were collected as both adult and immature life stages from 88 collections within 29 1-km areas. Fifteen of the 19 previously reported species were obtained, leaving the current status of four species uncertain. At least 11 species previously not reported from Åland, but confirmed on the Finnish mainland, were collected. Aedes geminus Peus was identified based on examination of the gonostylus, and represents a new species distribution for Finland. Anopheles maculipennis s.s. Meigen was confirmed from cytochrome c oxidase subunit I (COI) and internal transcribed spacer 2 (ITS2) sequence data and is reinstated on the list of Finnish species, along with Ochlerotatus sticticus (Meigen). Dahliana geniculata (Olivier) was found in two locations, in 2 months, indicating that there is an established population in Åland. The present data confirm that at least 27 species inhabit mainland Åland, rising to 31 when historical data are included. The Finnish mosquito fauna is increased from 38 to 41 species.

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“…Some are most probably endemic, i.e. Batai virus, Inkoo virus (INKV), Sindbis virus (SINV), Snowshoe hare virus, Chatanga virus [5], Tahyna virus, Usutu virus and West Nile virus; while some occur sporadically i.e. dengue- and chikungunya virus [2].…”

Section: Introductionmentioning

confidence: 99%

“…It is assumed that most infected persons are asymptomatic or present a mild febrile illness, which is self-limiting in most cases. However, in severe cases, it may cause a neuroinvasive disease that manifest in a form of encephalitis [5, 13]. The sero-prevalence of INKV is high among human populations in endemic areas of Finland (51%) and Sweden (41%) [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing

Lwande

Bucht

Ahlm

et al. 2017

Virol J

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BackgroundInkoo virus (INKV) is a less known mosquito-borne virus belonging to Bunyaviridae, genus Orthobunyavirus, California serogroup. Studies indicate that INKV infection is mainly asymptomatic, but can cause mild encephalitis in humans. In northern Europe, the sero-prevalence against INKV is high, 41% in Sweden and 51% in Finland. Previously, INKV RNA has been detected in adult Aedes (Ae.) communis, Ae. hexodontus and Ae. punctor mosquitoes and Ae. communis larvae, but there are still gaps of knowledge regarding mosquito vectors and genetic diversity. Therefore, we aimed to determine the occurrence of INKV in its mosquito vector and characterize the isolates.MethodsAbout 125,000 mosquitoes were collected during a mosquito-borne virus surveillance in northern Sweden during the summer period of 2015. Of these, 10,000 mosquitoes were processed for virus isolation and detection using cell culture and RT-PCR. Virus isolates were further characterized by whole genome sequencing. Genetic typing of mosquito species was conducted by cytochrome oxidase subunit I (COI) gene amplification and sequencing (genetic barcoding).ResultsSeveral Ae. communis mosquitoes were found positive for INKV RNA and two isolates were obtained. The first complete sequences of the small (S), medium (M), and large (L) segments of INKV in Sweden were obtained. Phylogenetic analysis showed that the INKV genome was most closely related to other INKV isolates from Sweden and Finland. Of the three INKV genome segments, the INKV M segment had the highest frequency of non-synonymous mutations. The overall G/C-content of INKV genes was low for the N/NSs genes (43.8–45.5%), polyprotein (Gn/Gc/NSm) gene (35.6%) and the RNA polymerase gene (33.8%) This may be due to the fact that INKV in most instances utilized A or T in the third codon position.ConclusionsINKV is frequently circulating in northern Sweden and Ae. communis is the key vector. The high mutation rate of the INKV M segment may have consequences on virulenceElectronic supplementary materialThe online version of this article (doi:10.1186/s12985-017-0725-5) contains supplementary material, which is available to authorized users.

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Acute Human Inkoo and Chatanga Virus Infections, Finland

Abstract: Most cases appeared to be subclinical, but a few patients, usually children, required hospitalization.

Cited by 40 publications

References 19 publications

Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

A report on the mosquitoes of mainland Åland, southwestern Finland and revised list of Finnish mosquitoes

Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing

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