Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report

Ziemele, Inga; Xu, Man; Vilmane, Anda; Rasa-Dzelzkalēja, Santa; Hedman, Lea; Hedman, Klaus; Söderlund‐Venermo, Maria; Nora-Krūkle, Zaiga; Murovska, Modra; Gardovska, Dace

doi:10.1186/s13256-019-2222-5

Cited by 12 publications

(8 citation statements)

References 30 publications

(48 reference statements)

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“…[ 21 ] 2008 French 192 NA NA Nasopharyngeal Aspirate 8.6 24 12.5 10 14 Midulla F et al. [ 11 ] 2010 Italy 182 NA NA Nasal Washings 2.5 22 12.5 15 7 Ricart S et al. [ 16 ] 2013 Spain 484 235 173 Nasopharyngeal Aspirate 12 119 24.58 NA NA Wang k et al.…”

Section: Resultsmentioning

confidence: 99%

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The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis

Falahi

Sayyadi

Abdoli

et al. 2020

New Microbes and New Infections

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Acute bronchiolitis is one of the most common lower respiratory tract infections in children with less than 2 years of age. Nowadays, molecular methods provide an opportunity to better understand the etiology of bronchiolitis. Several viral agents including Respiratory syncytial virus (RSV), Rhinovirus, Parainfluenza and Human bocavirus (HBoV) are responsible for acute bronchiolitis. There are growing studies on the prevalence of HBoV in patients with bronchiolitis. The present systematic review and meta-analysis were conducted to determine the pooled prevalence of HBoV in the respiratory samples of children with acute bronchiolitis. A literature search was conducted in the databases of PubMed, Scopus and Web of Science to recruit studies reporting the frequency of HBoV in <2-year-old children with acute bronchiolitis from 2005 to 2019. Only studies that used polymerase chain reaction (PCR)-based methods to detect the virus in nasopharyngeal samples were included. A total of 22 studies assessing 6751 cases were analyzed. According to the meta-analysis based on the random-effects model, the overall prevalence of HBoV in children with <2 years old was obtained 13% (95% CI: 0.09-0.17). Additionally, the rates of single (as the sole organism) and mixed (in combination with other viruses) HBoV infections were 4% and 9%, respectively. This study showed a high rate of HBoV detection in children with acute bronchiolitis. This should be considered as part of a diagnostic test panel for respiratory infections in children with bronchiolitis.

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Section: Resultsmentioning

confidence: 99%

“…So far, there has been one fatality reported in an immunocompetent child due to severe acute bronchiolitis caused by HBoV [ 11 ]. Some studies have described the HBoV as the second or third most prevalent cause of bronchiolitis [ 3 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis

Falahi

Sayyadi

Abdoli

et al. 2020

New Microbes and New Infections

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“…The more widespread detection of FBoV-1 in cats with enteric disease (Yi et al 2018 ) may indicate that different genotypes may exhibit different phenotypic characteristics, just like some members of bocaparvoviruses. For example, human bocaparvovirus 1 (HuBoV-1) is often associated with respiratory disease (Koseki et al 2012 ; Meriluoto et al 2012 ; Ziemele et al 2019 ) while HuBoV-2–4 has been associated with enteric diseases (Cheng et al 2011 ; Jin et al 2011 ). Garigliany et al ( 2016 ) reported the presence of FBoV-1 in the brain of an FPV-infected cat with neurological findings.…”

Section: Discussionmentioning

confidence: 99%

First detection of feline bocaparvovirus 2 and feline chaphamaparvovirus in healthy cats in Turkey

Hasan

Can-Şahna

2021

Vet Res Commun

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The pet cat’s population and the number of viruses that infect them are increasing worldwide. Recently, feline chaphamaparvovirus (FeChPV, also called fechavirus) and feline bocaparvovirus (FBoV) infections, which are novel parvovirus species, have been reported in cats from different geographic regions. Here, we investigated FBoV 1–3 and FeChPVs in healthy cats in Turkey using PCR, where nuclear phosphoprotein 1 (NP1) is targeted for FBoV and NP for FeChPV. For this purpose, oropharygeal swabs were obtained from 70 healthy cats with different housing status from June 15 to December 1, 2020. After PCR screening tests, six out of 70 cats (5/47 shelter cats; 1/23 domestic cats) were found to be positive for FBOV, while two were positive for FeChPV (1/47 shelter cats; 1/23 domestic cats). No cat was found in which both viruses were detected. The nucleotide (nt) sequence comparison in the 310 base pair (bp) NP gene of the two FeChPVs identified in this study shared a high identity with each other (95.0% nt and 99% aa identities) and with previously reported FeChPVs (92.4–97.1% nt and 98.1–99.0% aa identities), including 313R/2019/ITA, 49E/2019/ITA, VRI_849, 284R/2019/ITA, and IDEXX-1. Here, the near-full length (1489 nt, 495 amino acids-aa) of the VP2 gene of the FechaV/Tur-2020/68 isolate obtained from the study was also sequenced. The nt and aa identity ratio of this isolate with other FeChPVs was 98.0–98.5%-96–96.5%, respectively. Sequences of the 465 bp NP1 gene of the six Turkish FBoV strains shared high identities with each other (99.6–100% nt and 99.3–100% aa identities) and with those of FBoV-2 strains (97.8–99.1% nt and 98.0–100% aa identities), including 16SY0701, 17CC0505-BoV2, HFXA-6, and POR1. All FBoVs detected in this study were classified as genotype 2, similar to the study conducted in Japan and Portugal. Here, the NS1 (partial), NP1, VP1 and VP2 gene of the FBoV-2/TUR/2020–14 strain obtained from the study were also sequenced and the nt and aa sequences showed high identities to the above-mentioned FBoV-2 strain/isolates (> 96%, except for the aa ratio of strain 16SY0701). In conclusion, this study shows that FBoV and FeChPV are present in healthy cats in Turkey, and these viruses can be detected from oropharyngeal swabs. Our findings contribute to further investigation of the prevalence, genotype distribution, and genetic diversity of Turkish FBoVs and FeChPVs, adding to the molecular epidemiology of FBoV and FeChPVs worldwide.

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“…HBoV1 is often detected in conjunction with other pathogens; the frequency of coinfections is high, and the clinical symptoms are more severe than those associated with monoinfections (Sun et al, 2019 ). However, there have been instances of life-threatening infections caused by a single infection (Ziemele et al, 2019 ). Furthermore, it is not yet known whether HBoV is a true ARI pathogen, making the diagnosis of acute HBoV1 infection very challenging.…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

et al. 2022

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Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid–base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.

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Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report

Cited by 12 publications

References 30 publications

The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis

The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis

First detection of feline bocaparvovirus 2 and feline chaphamaparvovirus in healthy cats in Turkey

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

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