Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals

Ferrandi, Peter J.; Fico, Brandon G.; Whitehurst, Michael; Zourdos, Michael C.; Bao, Fanchen; Dodge, Katelyn M.; Rodriguez, Alexandra L.; Pena, Gabriel S.; Huang, Chun-Jung

doi:10.1016/j.lfs.2018.04.007

Cited by 32 publications

(30 citation statements)

References 38 publications

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“…Exercise immunology investigators had an early focus on the large perturbations of basic leukocyte subsets associated with the physiological stress of athletic endeavor 2 , 9, 10, 11, 12, 13, 14 , 27 . Increasing attention is being directed to the enhanced immunosurveillance of distinct immune cell subtypes during exercise bouts of less than 60 min that have potential prevention and therapeutic value 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48…”

Section: Acute and Chronic Effects Of Exercise On The Immune Systemmentioning

confidence: 99%

The compelling link between physical activity and the body's defense system

Nieman

Wentz

2019

Journal of Sport and Health Science

914

955

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Highlights Acute exercise is an immune system adjuvant that improves defense activity and metabolic health. Data support a clear inverse relationship between moderate exercise training and illness risk. Exercise training has an anti-inflammatory influence mediated through multiple pathways. Illness risk is increased in athletes during periods of intensified training and competition. Increased carbohydrate and polyphenol intake is an effective nutritional strategy for immune support. Habitual exercise improves immune regulation, delaying the onset of age-related dysfunction. Advances in mass spectrometry technology will provide new insights on exercise–immune responses.

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Section: Acute and Chronic Effects Of Exercise On The Immune Systemmentioning

confidence: 99%

The compelling link between physical activity and the body's defense system

Nieman

Wentz

2019

Journal of Sport and Health Science

914

955

View full text Add to dashboard Cite

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“…HIIT protocols include SIT (sprint interval training) and AIT (aerobic interval training), where the former has short intervals, such as 30 s, the latter has longer ones, such as 3 min to 4 min. The most common modality using HIIT with populations with chronic pathologies is AIT, which consists of four to five intervals of 4 min duration at an intensity of around 85-90% of peak heart rate (HR peak ), followed by a recovery period of 3 min at about 70% of HR peak [16][17][18][19][20]. AIT is well-tolerated, safe, improves quality of life and promotes adherence to exercise for overweight/obese patients and overweight/obese patients with cardiovascular disease and/or metabolic syndrome [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

A Qualitative Analysis of an Aerobic Interval Training Programme for Obese Outpatients Carried Out in a Hospital Context

Cabanillas-Cruz

López-Rodriguez

Romero‐Blanco

et al. 2020

IJERPH

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Purpose: To describe the experience of obese adults following participation in an indoor aerobic interval training (AIT) intervention. Methodology: Qualitative, in-depth semi-structured individual interviews, using phenomenology, with 24 obese adults (body mass index (BMI) ≥30 kg/m2) from the Endocrinology Department, at the Severo Ochoa Hospital in Leganés (Madrid). Questions were related to: (a) The physical activity (PA) programme, (b) their perspectives of the activity and exercise environment and (c) the perceived benefits from participation. Data were analysed with a constant comparison approach. Results: The main patients’ reasons for beginning the programme were motivations to take part including weight loss, health improvement and doctors’ recommendation. Also, patients showed doubts and feelings of apprehension at the beginning of the intervention. Patients highlighted the role of the instructor, feelings of exercising in a safe environment, a good intervention and accessibility of the facility. They reported an improvement in their quality of life and recommended continuing the program. Conclusions: (1) Common themes in the qualitative analysis included enjoyment of the activity and a desire to maintain physical fitness, (2) AIT was perceived as a suitable exercise programme for this population and (3) recommendations for further investigation to understand the role of PA programmes for people with obesity.

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“…To this end, the overtraining and induced inflammation are well reflected in C-reactive protein (CRP) levels as the marker of inflammation and highly increased concentration of plasma cfDNA in proportion to training load [ 66 ]. In addition, there is no any significant difference in circulating cfDNA between obese and normal-weight subjects [ 67 ]. Noteworthy, although remaining unchanged in its absolute quantity, the proportional input by the foetal cfDNA is reduced in mother’s blood by increased concentration of cfDNA linked to the exercise during and immediately after the physical activity.…”

Section: Physical Activity and Exercise-induced Oxidative Stressmentioning

confidence: 99%

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

et al. 2020

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Interest in the use of cell-free nucleic acids (CFNAs) as clinical non-invasive biomarker panels for prediction and prevention of multiple diseases has greatly increased over the last decade. Indeed, circulating CFNAs are attributable to many physiological and pathological processes such as imbalanced stress conditions, physical activities, extensive apoptosis of different origin, systemic hypoxic-ischemic events and tumour progression, amongst others. This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Presented considerations conform with principles of 3P medicine and serve for improving individual outcomes and cost efficacy of medical services provided to the population.

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Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals

Cited by 32 publications

References 38 publications

The compelling link between physical activity and the body's defense system

The compelling link between physical activity and the body's defense system

A Qualitative Analysis of an Aerobic Interval Training Programme for Obese Outpatients Carried Out in a Hospital Context

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

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