Acute high-frequency rTMS of the left dorsolateral prefrontal cortex and attentional control in healthy young men

Hwang, Jeoung Yeon; Kim, Sang Hee; Park, Chang Soo; Bang, Seong Ae; Kim, Sang Eun

doi:10.1016/j.brainres.2010.03.013

Cited by 49 publications

(35 citation statements)

References 44 publications

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“…For example, healthy young females who received one session of high-frequency (10 Hz) rTMS over the left dorsolateral prefrontal cortex (DLPFC) performed better in a Stroop task than those who received sham stimulation [13]. A similar improvement was observed by Hwang [14] who found that healthy young males showed fewer commission errors in a Conners' continuous performance test after rTMS. However, Rounis E [15] found that there was no improvement in attentional reorienting after one session of HF-rTMS applied over the left DLPFC in healthy volunteers.…”

Section: Introductionmentioning

confidence: 77%

“…The results of previous studies have suggested that a single session of rTMS decreases reaction time (RT) in the Stroop task of healthy participants [13, 14]. ERP data have indicated that the amplitudes of the error-related negativity (ERN) and subsequent error-positivity (Pe) components were also altered in a typical Eriksen flanker task after rTMS [40].…”

Section: Introductionmentioning

confidence: 99%

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The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants

Wang

Meng

et al. 2017

PLoS ONE

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A large body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) is clinically effective in treating neuropsychiatric disorders and multiple sessions are commonly used. However, it is unknown whether multiple sessions of rTMS improve cognitive control, which is a function of the neural circuitry of the left dorsolateral prefrontal cortex (DLPFC)-cingulate cortex in healthy individuals. In addition, it is still unclear which stages of neural processing are altered by rTMS. In this study, we investigated the effects of high-frequency rTMS on cognitive control and explored the time course changes of cognitive processing after rTMS using event-related potentials (ERPs). For seven consecutive days, 25 young healthy participants underwent one 10-Hz rTMS session per day in which stimulation was applied over the left DLPFC, and a homogeneous participant group of 25 individuals received a sham rTMS treatment. A Stroop task was performed, and an electroencephalogram (EEG) was recorded. The results revealed that multiple sessions of rTMS can decrease reaction time (RTs) under both congruent and incongruent conditions and also increased the amplitudes of both N2 and N450 compared with sham rTMS. The negative correlations between the mean amplitudes of both N2 and N450 and the RTs were found, however, the latter correlation were restricted to incongruent trials and the correlation was enhanced significantly by rTMS. This observation supports the view that high-frequency rTMS over the left DLPFC can not only recruit more neural resources from the prefrontal cortex by inducing an electrophysiologically excitatory effect but also enhance efficiency of resources to deploy for conflict resolution during multiple stages of cognitive control processing in healthy young people.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants

Wang

Meng

et al. 2017

PLoS ONE

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“…An offline approach of repeated trains of high frequency stimulation for 10-20 minutes immediately preceding a task has also produced performance enhancements (Boyd et al, 2009; Hwang et al, 2010; Ragert et al, 2003; Tegenthoff et al, 2005). For example, twenty-five 10 s trains of 5Hz rTMS reduced subsequent tactile discrimination thresholds for up to two hours (Tegenthoff et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS)

2014

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Here we review the usefulness of transcranial magnetic stimulation (TMS) in modulating cortical networks in ways that might produce performance enhancements in healthy human subjects. To date over sixty studies have reported significant improvements in speed and accuracy in a variety of tasks involving perceptual, motor, and executive processing. Two basic categories of enhancement mechanisms are suggested by this literature: direct modulation of a cortical region or network that leads to more efficient processing, and addition-by-subtraction, which is disruption of processing which competes or distracts from task performance. Potential applications of TMS cognitive enhancement, including research into cortical function, rehabilitation therapy in neurological and psychiatric illness, and accelerated skill acquisition in healthy individuals are discussed, as are methods of optimizing the magnitude and duration of TMS-induced performance enhancement, such as improvement of targeting through further integration of brain imaging with TMS. One technique, combining multiple sessions of TMS with concurrent TMS/task performance to induce Hebbian-like learning, appears to be promising for prolonging enhancement effects. While further refinements in the application of TMS to cognitive enhancement can still be made, and questions remain regarding the mechanisms underlying the observed effects, this appears to be a fruitful area of investigation that may shed light on the basic mechanisms of cognitive function and their therapeutic modulation.

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“…In particular, our findings of disrupted connectivity between the ventral attention network and dorsal attention network help elucidate the neural underpinnings of poor attentional control, a fundamental impairment in schizophrenia (e.g., (Nuechterlein et al, 2009)). Understanding the nature of network mechanisms underlying cognitive deficits of schizophrenia and how regional organization within and between networks is disrupted in terms of connectivity will aid in the development of novel therapeutic strategies (Hwang et al, 2010; Smucny et al, 2016a, 2016b, 2015) and may help shed light on the pathophysiology of this disorder.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity when detecting rare visual targets in schizophrenia

Jimenez

Lee

Green

et al. 2017

Psychiatry Research: Neuroimaging

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Individuals with schizophrenia demonstrate difficulties in attending to important stimuli (e.g., targets) and ignoring distractors (e.g., non-targets). We used a visual oddball task during fMRI to examine functional connectivity within and between the ventral and dorsal attention networks to determine the relative contribution of each network to detection of rare visual targets in schizophrenia. The sample comprised 25 schizophrenia patients and 27 healthy controls. Psychophysiological interaction analysis was used to examine whole-brain functional connectivity in response to targets. We used the right temporo parietal junction (TPJ) as the seed region for the ventral network and the right medial intraparietal sulcus (IPS) as the seed region for the dorsal network. We found that connectivity between right IPS and right anterior insula (AI; a component of the ventral network) was significantly greater in controls than patients. Expected patterns of within- and between-network connectivity for right TPJ were observed in controls, and not significantly different in patients. These findings indicate functional connectivity deficits between the dorsal and ventral attention networks in schizophrenia that may create problems in processing relevant versus irrelevant stimuli. Understanding the nature of network disruptions underlying cognitive deficits of schizophrenia may help shed light on the pathophysiology of this disorder.

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Acute high-frequency rTMS of the left dorsolateral prefrontal cortex and attentional control in healthy young men

Cited by 49 publications

References 44 publications

The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants

The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants

Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS)

Functional connectivity when detecting rare visual targets in schizophrenia

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