Acute hepatitis with autoimmune features after COVID-19 vaccine: coincidence or vaccine-induced phenomenon?

COVID-19 vaccine triggered autoimmune hepatitis: case report

“…This was identified to have an adequate temporal relationship (10 days) with the incidence of the disease (AIH). Other similar cases of AIH following COVID-19 immunisation also reported a similar graph of latency period 2–4. Our study discussed and eliminated other possible confounding factors but found vaccination was the only immediate event that triggered the condition in this patient.…”

Histological and serological features of acute liver injury after SARS-CoV-2 vaccination

“…The patient characteristics at the time of the hepatitis diagnosis, treatment and outcomes are summarized in Table 1. Data of eleven patients have been previously published, before the centralized histological and serological evaluation presented here; their follow up has been updated (9,13,(31)(32)(33). in various combinations before the diagnosis of liver injury (Figure 1).…”

Insights into new-onset autoimmune diseases after COVID-19 vaccination

“…However, both conditions have also been reported in AIH [ 141 , 142 ]. To date, COVID-19 vaccines that induce AIH include mRNA vaccines, viral vector vaccines, and inactivated vaccines, with mRNA vaccines accounting for the majority and inactivated vaccines accounting for the least [ 15 , 140 , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] , [167] , [168] ]. Clayton-Chubb et al reported for the first time a case of adenovirus-based vaccine eliciting AIH.…”