Acute Hepatitis Related to Omeprazole

Romero‐Gómez, Manuel; Otero, M. Ángeles; Suárez-García, Emilio; Díaz, E. García; Fobelo, María José; Castro‐Fernández, Manuel

doi:10.1111/j.1572-0241.1999.01119.x

Cited by 26 publications

(13 citation statements)

References 4 publications

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“…In several series, a trend toward markedly lower or normal serum alanine aminotransferase (ALT) levels in the third trimester has been noted, with a return to pre-pregnancy levels in the first 3 to 6 months postpartum. 7,8 At the same time, a rise in serum HCV RNA levels has been detected. 9,10 The improvement in serum ALT levels may be caused by physiologic changes associated with pregnancy including expansion in plasma volume, high plasma concentrations of estrogen, and changes in immune reactivity.…”

Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 69%

“…In some women, HCV RNA levels rise toward the end of pregnancy. 7,9,10 The rise appears to be on the order of 50% above baseline. However, a few patients in one study were found to have undetectable serum HCV RNA during pregnancy, becoming positive for HCV RNA again in the postpartum period, 7 and in another small study HCV RNA levels fluctuated during pregnancy and became lower or undetectable in the postpartum period.…”

Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 99%

“…7,9,10 The rise appears to be on the order of 50% above baseline. However, a few patients in one study were found to have undetectable serum HCV RNA during pregnancy, becoming positive for HCV RNA again in the postpartum period, 7 and in another small study HCV RNA levels fluctuated during pregnancy and became lower or undetectable in the postpartum period. 14 If elevated viral levels are a risk factor for mother-to-infant transmission, then levels should be measured in the third trimester, because the measured concentrations of HCV RNA at the onset of pregnancy may be neither representative nor predictive of the HCV RNA concentration at the time of delivery.…”

Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 99%

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Maternal-infant transmission of hepatitis C virus infection

2002

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Mother-to-infant transmission of hepatitis C virus (HCV) is comparatively uncommon. The prevalence of antibody to HCV (anti-HCV) in pregnant women is 0.1% to 2.4%, although in some endemic areas it is much higher. The proportion of women with anti-HCV who have active infection with viremia is 60% to 70%. Transmission of HCV occurs only when serum HCV RNA is detectable and may be related to higher levels (above 10 6 copies per mL). M aternal and child health issues relating to hepatitis C virus (HCV) infection have recently assumed greater importance than ever before. From the pediatric perspective, the availability of effective screening methods for HCV has virtually eliminated new cases of transfusion-associated hepatitis C in children. Consequently, childhood acquisition of HCV infection through maternal-infant transmission has become the most important mode of spread. 1 Vertical, or more precisely, mother-to-infant hepatitis C will likely be the major type of childhood chronic hepatitis C within the next 6 to 8 years. It has been difficult to determine the rate of mother-to-infant transmission, partly because reports of mother-to-infant transmission of HCV have been based on small numbers of patients, with differing disease definitions, followed with different study designs and using different virological assays. These reports tended to be heterogeneous and conflicting. Moreover, factors that promote mother-to-infant transmission and the outcome of chronic HCV infection acquired by this route still require clarification. Likewise, for women of child-bearing age who acquired chronic hepatitis C in childhood or in early adulthood, there are important issues relating to pregnancy itself, such as its effect on the disease course of chronic hepatitis C. Prevalence of Hepatitis C Among Pregnant WomenNumerous studies have examined the prevalence of hepatitis C among pregnant women (Table 1). The studies vary considerably in terms of the size of the study, geographic variables, and adequacy of laboratory testing. In general, the prevalence of detectable antibody to HCV (anti-HCV) is approximately 1% overall (range, 0.1% to 2.4%), based on the studies that included at least 3,000 subjects. The mean Abbreviations: HCV, hepatitis C virus; anti-HCV, antibody to HCV; ALT, alanine aminotransferase; HIV, human immunodeficiency virus.

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Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 69%

Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 99%

Section: Issues Relating To Pregnancy and Chronic Hepatitis Cmentioning

confidence: 99%

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Maternal-infant transmission of hepatitis C virus infection

2002

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“…Possible interaction of some PPIs with the TAC metabolism must be considered; however, we have not observed such an interaction in this cohort [13]. By thorough observation of the liver allograft using protocol liver biopsies and biochemical monitoring we can exclude any cases of acute hepatitis attributable to PPI use as has been previously reported [14].…”

Section: Discussionmentioning

confidence: 78%

Acid blocking medication usage pre and post liver transplantation

et al. 2007

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“…Since all PPI are metabolized in the liver by cytochrome CYP450, the dosages of the most available PPI should be reduced in these patients. [34] Moreover, acute hepatitis due to PPI use was previously related, [35] while gastric acid suppression can increase the risk of community-acquired pneumonia [36] and spontaneous bacterial peritonitis in advanced cirrhosis. [37][38][39] 3.3.2 Sucralfate Sucralfate is a complex of disaccharide sugar, sulfate, sucrose and aluminum.…”

Section: Risk Factorsmentioning

confidence: 99%

Diagnosis, management and prophylaxis of bleeding related to post-esophageal variceal band ligation ulcer in cirrhotic patients

Lima

Silva

Romeiro

2018

CRIM

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Esophageal varices develop in half of cirrhotic patients. Endoscopic variceal band ligation is the current treatment for acute bleeding and applicable for primary and secondary prophylaxis. However, there is a risk of complications, including ligationinduced ulcer bleeding. The aim of this study is to review the current diagnosis, management and prophylaxis of bleeding related to post-esophageal variceal band-ligation ulcers in cirrhotic patients. PubMed and Google Scholar were searched for English language articles about the theme. The main findings were that Child-Pugh class C, higher model of end-stage liver disease, emergency ligation, presence of hepatocellular carcinoma, peptic esophagitis and bacterial infection were reported as the most important risk factors for post-banding ulcer hemorrhage. There are few studies with proton pump inhibitors and sucralfate showing size reduction of post-banding ulcers. Many treatment modalities have been used to control post band ulcer bleeding, such as band local injection of epinephrine or cyanoacrylate, balloon tamponade, stent placement and ligation of the ulcerated bleeding site. However, the optimal management remains uncertain. The principal conclusions of the study were that post-banding ulcer bleeding is potentially life-threatening and must be suspected in the presence of hematemesis, melena or anemia after endoscopic variceal band ligation (EVL). Predictors of rebleeding must be assessed and controlled as much as possible before band ligation. The post-banding treatment with proton pump inhibitors or sucralfate seems advisable, in particular for high-risk patients. Further investigation and new approaches are still required to achieve optimal management of this complication.

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Acute Hepatitis Related to Omeprazole

Cited by 26 publications

References 4 publications

Maternal-infant transmission of hepatitis C virus infection

Maternal-infant transmission of hepatitis C virus infection

Acid blocking medication usage pre and post liver transplantation

Diagnosis, management and prophylaxis of bleeding related to post-esophageal variceal band ligation ulcer in cirrhotic patients

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