Acute Hepatitis Non-A, Non-B following Administration of Factor VIII Concentrates

Abstract

A retrospective survey on clinical hepatitis in patients with bleeding disorders was performed. Nine episodes of hepatitis non-A, non-B occurred in 8 out of 20 patients (40%) with mild hemophilia A or von Willebrand’s disease, who had been treated with commercial factor VIII concentrates. Only two episodes of hepatitis B occurred during the study period. The non-A, non-B attack rate after the first treatment was 40 % with factor VIII concentrate obtained from large plasma pools (≈2,000 donors) including professional plasma donors as compared to 8 % after treatment with factor VIII concentrate obtained from smaller (100-250 donors) plasma pools from Scandinavian donors.