Acute Hepatitis E by a New Isolate Acquired in the United States

Kwo, Paul Y.; Schlauder, George G.; Carpenter, Herschel A.; Murphy, Paul J.; Rosenblatt, Jon E.; Dawson, George J.; Mast, Eric E.; Krawczynski, Krzysztof; Balan, Vijayan

doi:10.4065/72.12.1133

Cited by 174 publications

(145 citation statements)

References 15 publications

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“…Telefax: (+5565) 3615-8863, E-mail: fsouto@terra.com.br infect nonhuman primates, suggesting that human infection could supervene from the same route (7). In the last few years, novel strains of human HEV have been recovered from patients with acute hepatitis E in North America, Europe, and Asia (4,13,21). Interestingly, these HEV strains share higher genetic identity with local swine HEV strains than with other human HEV isolates worldwide, reinforcing the hypothesis of zoonotic transmission (18,20).…”

Section: Introductionmentioning

confidence: 85%

Hepatitis E virus antibodies in swine herds of Mato Grosso state, Central Brazil

Guimarães¹,

Saddi²,

Vitral³

et al. 2005

Braz. J. Microbiol.

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There is no information about evidence of hepatitis E virus (HEV) infection in swines in Central Brazil. In order to assess if HEV circulates in swines of the State of Mato Grosso, Central Brazil, a seroprevalence study was conducted including pigs from 17 farms, corresponding to 13 counties. The animals were randomly chosen among pigs arriving to two slaughterhouses between December 2002 and February 2003. Serum samples were collected and tested for IgG antibodies against HEV (anti-HEV) by enzyme immunoassay (EIA). This EIA uses two HEV recombinant proteins as antigens, a mosaic protein (MP-II) and a protein containing region 452-617 of the ORF2 of the HEV Burma strain as coating antigens. 211 out of 260 pigs (81.2%; 95CI = 75.7%, 85.6%) were anti-HEV reactive. The seropositivity did not vary with gender or age, but ranges from 15% to 100% among the farms. Our results point out that HEV seems to circulate among pigs in Mato Grosso State, suggesting that this virus is spread over the region, as seen in other countries worldwide.

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Section: Introductionmentioning

confidence: 85%

Hepatitis E virus antibodies in swine herds of Mato Grosso state, Central Brazil

Guimarães¹,

Saddi²,

Vitral³

et al. 2005

Braz. J. Microbiol.

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show abstract

“…64,65 This mode of transmission was initially suspected because of the observation that genomic sequences of HEV isolates from two autochthonous cases in the United States were more closely-related to swine HEV than to human HEV isolates. 9,11 Subsequent experimental studies showed that human genotype 3 and 4 HEV could infect experimental pigs, and that swine HEV isolates could be transmitted to primates, which served as a surrogate for humans. 11,66 More direct evidence for zoonotic transmission came from a cluster of cases in two Japanese families that had shared a meal consisting of inadequately-cooked deer meat a few weeks prior to the onset of illness.…”

Section: Reservoir Of Infection and Mode Of Transmissionmentioning

confidence: 99%

“…[9][10][11] Around the same time, HEV-like genomic sequences were identified in specimens from animals, in particular pigs. 12 Further work prompted by these observations has led to a major change in our understanding about HEV and its epidemiology, including the routes of transmission and clinical outcomes.…”

mentioning

confidence: 98%

Hepatitis E: Epidemiology and Natural History

Aggarwal

2013

Journal of Clinical and Experimental Hepatology

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“…However, autochthonous HEV infections have recently been documented from developed countries like France, Japan, United Kingdom and USA. [13][14][15] While contaminated water and food remains the source of infection in developing world, zoonotic transmission of HEV has been documented in developed industrialized nations.…”

Section: Hepatitis E Virus Burdenmentioning

confidence: 99%