Acute Hepatitis B with Pancreatitis and Cholecystitis Leading to Acute Liver Failure and Death

Albert, Anthony H.; Valencia, Ronald; Smereck, Janet

doi:10.5811/cpcem.2018.7.38344

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…However, 8 case studies and case series, in which individual data for each patient were not available, were excluded from the analyses. As a result, 46 studies reporting data on 73 patients were included [ 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Panić

Mihajlovic

Vujasinović

et al. 2020

JCM

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Background: We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis. Methods: A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was conducted and papers eligible for the inclusion identified. Results: In total, 46 studies reporting data on 73 patients were included in the analysis. Most of the cases were diagnosed in Asia (57.53%), followed by North America (23.29%), and Europe (13.70%). Most of the patients were affected by hepatitis A virus (HAV) (42.47%), followed by hepatitis E virus (HEV) (28.77%), hepatitis B virus (HBV) (8.22%), and hepatitis C virus (HCV) (1.37%), while 17.81% at the time of diagnosis were classified as affected by “hepatitis virus”. Pancreatitis was severe in 32.88% of cases. The respiratory system was affected in 2.74% of patients, 6.85% experienced renal failure, while 5.48% experienced a multiorgan dysfunction syndrome (MODS). Four patients (5.48%) needed pancreatic surgery. Despite the treatment, 21.92% of patients died. We identified fulminant hepatitis (p < 0.0001), MODS (p < 0.0001) and severe pancreatitis (p < 0.0001) to be significantly more present in patients who died in comparison to cured ones. Conclusion: Increased awareness of pancreatic involvement in viral hepatitis is needed because it can have a substantial impact on therapeutic approaches and outcomes.

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Section: Resultsmentioning

confidence: 99%

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Panić

Mihajlovic

Vujasinović

et al. 2020

JCM

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“…7,10,14,15 Hepatitis A infections linked to pancreatitis and cholecystitis happen in 5% of instances as a result of the virus's direct invasion. 16 Acute acalculous cholecystitis is a very rare condition and has not been widely reported. 6,12,17,18 acute acalculous cholecystitis is an uncommon gallbladder infection without gallstones, yet it progresses rapidly.…”

Section: Discussionmentioning

confidence: 99%

Acute Acalculous Cholecystitis Associated with Hepatitis A Viral Infection: A Case Report

Ariobimo

Nujum

Saputro³

2023

IJTID

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Most hepatitis A infections are acute, self-limiting, and asymptomatic. In rare instances, extra hepatic complication, such as acute cholecystitis, may emerge. Acute cholecystitis is inflammation of the gallbladder wall and is classified into calculus and acalculus. About 90–95% of cases are brought on by bile duct stones. Acute acalculous cholecystitis can be brought on by structural and functional abnormalities in the gallbladder brought on by viral hepatitis infection. Here we present a 20 years old female patient with acute acalculous cholecystitis associated with hepatitis A infection. Gallbladder distention, thickening of the gallbladder wall, absence of acoustic shadow or biliary sludge, perivesical liquid buildup, and absence of dilatation of the intra- and extrahepatic bile ducts are among the ultrasonographic criteria for diagnosing acute acalculous cholecystitis. The viral hepatitis serology revealed acute hepatitis A infection with positive anti-HAV IgM. Hepatitis A testing should be considered in patients suspected with acalculous cholecystitis of undefined etiology in markedly deranged liver function test adult patients.

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“…By regulating key proteins in these pathways, these may be targets for future HB treatment. .833 13 29 AIRE, PSMB9, HCK, PSMA7, PSMB5, PSMA3, PSMB8, AR, PLCG1, MET, FASLG, SRC, PSMD1 2 3.5 9 14 CHUK, SOCS3, STAT3, GRB2, CXCR4, NFKBIA, TNFRSF1A, JAK1, PTPRC 3 3.5 9 HB as an acute and chronic infectious disease caused by HBV infection that can cause systemic metabolic disorders, abnormal digestion and absorption, jaundice, nervous system diseases, immune disorders, renal insufficiency, and other systemic phenotypes [33]. These symptoms may be related to the in vivo biological effects of pathways associated with HB-related target enrichment.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment

Lü

Zhou

et al. 2020

BMC Complement Med Ther

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Background: Yiganling (YGL) capsule is a traditional Chinese medicine preparation consisting of eight herbs that has been clinically proven to have a favorable treatment effect on Hepatitis B (HB). However, due to its multiple targets and multi-pharmacological effects, the mechanisms of YGL capsule in the treatment of HB are unknown. Methods: First, the chemical constituents of YGL capsules were obtained from the Chinese medicine database, and YGL capsules were constructed. Second, active compounds were screened by the ADME model. The target fishing model was used to screen the corresponding targets of active compounds and to construct a compounds and compound targets network. Using human disease databases and literature mining, we systematically identified genes associated with HB, constructed disease-specific protein-protein interaction networks, and performed clustering and enrichment analyses of these networks. These networks were then merged to obtain a compounddisease target network, and cluster and enrichment analyses were performed on the compound-disease target network to acquire a compounds-disease targets-mechanism network and a clustering network. Results: We successfully built eight pharmacological network diagrams, including four primary networks and other network maps. The four dominating network maps included a HB disease-associated protein-protein interaction network, a YGL capsule compounds-target network, a YGL capsule ingredient target-HB disease target network, and a YGL-HB disease mechanism network. Other networks included a pathway of HB disease targets, the HB disease protein-protein interaction cluster analysis network, and the YGL-HB target clustering network. Conclusion: This study successfully forecasted, illuminated, and confirmed the synergistic effects of HB disease molecules and discovered the potential of HB relevant targets, clusters, and target-related biological processes and signaling pathways. Our research not only provides theoretical support for the molecular and pharmacological mechanisms of YGL capsule in HB treatment, but also provides new research methods for the study of the other traditional Chinese medicinal compounds.

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Acute Hepatitis B with Pancreatitis and Cholecystitis Leading to Acute Liver Failure and Death

Cited by 7 publications

References 24 publications

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Acute Acalculous Cholecystitis Associated with Hepatitis A Viral Infection: A Case Report

Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment

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