Acute Hepatitis and Liver Failure Associated With Influenza A Infection in Children

Whitworth, John; Mack, Cara L.; OʼConnor, Judith; Narkewicz, Michael R.; Mengshol, Sarah; Sokol, Ronald J.

doi:10.1097/01.mpg.0000232332.00677.3d

Cited by 31 publications

(28 citation statements)

References 5 publications

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“…Depletion of mtDNA is the most common cause of multi-systemic oxidative phosphorylation defects (100), with deoxyguanosine kinase (DGUOK) deficiency being the most frequent cause. Death commonly results from liver failure (26, 97, 101, 102), which may occur in the context of natural disease progression, exposure to sodium valproate (103–105) or complications of viral infections such as influenza (55, 106). Less severe attenuation of DGUOK function may result in a susceptibility to isolated liver failure (97, 107, 108) or a myopathic presentation of DGUOK deficiency (109).…”

Section: Introductionmentioning

confidence: 99%

Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome

Bennett

Helbling

Meng

et al. 2016

Free Radical Biology and Medicine

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A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described. The rat model recapitulates the pathologic and biochemical signatures of the human disease. The application of electron paramagnetic (spin) resonance (EPR) spectroscopy to the identification and characterization of respiratory chain abnormalities in the mitochondria from freshly frozen tissue of the mitochondrial disease model rat is introduced. EPR is shown to be a sensitive technique for detecting mitochondrial functional abnormality in situ and, here, is particularly useful in characterizing the redox state changes and oxidative stress that can result from depressed expression and/or diminished specific activity of the distinct respiratory chain complexes. As EPR requires no sample preparation or non-physiological reagents, it provides information on the status of the mitochondrion as it was in the functioning state. On its own, this information is of use in identifying respiratory chain dysfunction; in conjunction with other techniques, the information from EPR shows how the respiratory chain is affected at the molecular level by the dysfunction. It is proposed that EPR has a role in mechanistic pathophysiological studies of mitochondrial disease and strong potential as an additional diagnostic tool.

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Section: Introductionmentioning

confidence: 99%

Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome

Bennett

Helbling

Meng

et al. 2016

Free Radical Biology and Medicine

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show abstract

“…Severe abdominal pain associated with influenza may occur in school‐aged children, and there are case reports of influenza mimicking an acute abdomen as in our patient . Elevation of transaminases may occur, and rare cases of hepatic failure have been reported . Reye's syndrome, often associated with salicylate exposure, and more commonly with influenza B, may result in fatal outcomes …”

mentioning

confidence: 64%

Influenza virus infection mimicking an acute abdomen in a female adolescent

Vivar

Uyeki

2013

Influenza Resp Viruses

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“…1 is, to our knowledge, the first report of such co-infection. In this observation, severe transaminitis may have been imputed to flu, 54 which warrants considering possible concurrent infections in such setting. Fig.…”

Section: Discussionmentioning

confidence: 98%