Acute hepatic dysfunction in juvenile rheumatoid arthritis

Kornreich, Helen; Malouf, Nadia N.; Hanson, Virgil

doi:10.1016/s0022-3476(71)80054-9

Cited by 43 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relatively high frequency of adverse reactions in the GSTM group accords with previous studies (5,25,31,34). Severe adverse reactions to GSTM have also been reported in children, such as hepatic toxicity (11,16,20), neutropenia (37) as well as nephropathia (19). However, such severe adverse reactions seem to be confined to patients with the systemic type of the disease.…”

Section: Discussionmentioning

confidence: 99%

Gold Sodium Thiomalate and D-Penicillamine:A Controlled, Comparative Study in Patients with Pauciarticular and Polyarticular Juvenile Rheumatoid Arthritis

Kvien¹,

Høyeraal²,

Sandstad

1985

Scandinavian Journal of Rheumatology

View full text Add to dashboard Cite

Seventy-seven consecutive patients with pauciarticular or polyarticular juvenile rheumatoid arthritis were randomized to treatment with either gold sodium thiomalate (GSTM) or D-penicillamine (PEN) in a parallel 50-week clinical trial. Adverse reactions were reported by or observed in 9 GSTM-treated and 15 PEN-treated patients. Of these, 5 and 7 respectively were withdrawn from the study. Most disease activity measurements were changed in favour of the GSTM group, compared with the PEN group, but significant differences between the treatment regimens were observed for only a few measurements. This possible advantage of GSTM with regard to efficacy was only seen in patients with the polyarticular disease type.

show abstract

Section: Discussionmentioning

confidence: 99%

Gold Sodium Thiomalate and D-Penicillamine:A Controlled, Comparative Study in Patients with Pauciarticular and Polyarticular Juvenile Rheumatoid Arthritis

Kvien¹,

Høyeraal²,

Sandstad

1985

Scandinavian Journal of Rheumatology

View full text Add to dashboard Cite

show abstract

“…Although the positive results of the rheumatoid arthritis latex-agglutination test may have reflected the chronic liver disease, they may also have been caused by the primary rheumatic disease. Rheumatoid factor positivity in systemic-onset juvenile rheumatoid arthritis is present in 10-16% of patients (6,(17)(18)(19)(20). It has also been present in adult onset Still's disease (7,21).…”

Section: Discussionmentioning

confidence: 99%

Chronic liver disease and still's disease

Tesser

Pisko

Hartz

et al. 1982

Arthritis & Rheumatism

View full text Add to dashboard Cite

“…However, Kornreich, Malouf, and Hanson (1971) described seven children with acute changes in hepatic function during the course of JRA. Five of these patients, who were treated with salicylates, showed an abrupt drop in the Erythrocyte Sedimentation rate concomitant with the appearance of hepatic dysfunction as well as raised serum transaminase levels.…”

Section: Discussionmentioning

confidence: 99%

Salicylate-induced consumption coagulopathy.

Pinedo¹,

Putte²,

Loeliger³

1973

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Raised serum transaminase levels injuvenile rheumatoid arthritis (JRA) treated with salicylates have been reported by Russell, Sturge, and Smith (1971 Case report A 15-year-old boy was referred to the Leiden University Medical Centre. During hospitalization elsewhere he had been treated for suspected rheumatic fever with salicylates in doses up to 6 g. daily for 2 weeks, and 3 days before his admission at Leiden, the excision of a lymph node from the right axilla (histology: non-specific inflammation) had resulted in profuse bleeding requiring five blood transfusions (2,500 ml.). Thrombocytopenia had been demonstrated (thrombocytes 20,000 per p1.

show abstract

Acute hepatic dysfunction in juvenile rheumatoid arthritis

Cited by 43 publications

References 16 publications

Gold Sodium Thiomalate and D-Penicillamine:A Controlled, Comparative Study in Patients with Pauciarticular and Polyarticular Juvenile Rheumatoid Arthritis

Gold Sodium Thiomalate and D-Penicillamine:A Controlled, Comparative Study in Patients with Pauciarticular and Polyarticular Juvenile Rheumatoid Arthritis

Chronic liver disease and still's disease

Salicylate-induced consumption coagulopathy.

Contact Info

Product

Resources

About