Acute Hemothorax Owing to Pulmonary Arteriovenous Malformation in Pregnancy

Chanatry, Brian J.

doi:10.1213/00000539-199204000-00026

Cited by 15 publications

(9 citation statements)

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“…These lesions can be associated with a variety of life-threatening complications, such as stroke, brain abscess, hemothorax, and hemoptysis, especially in women [28,29]. Rupture of a PAVM can occur at any age, independently of lesion size [30-32]. Without appropriate treatment mortality exceeds 11% [33].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary arteriovenous malformations presenting as difficult-to-control asthma: a case report

et al. 2013

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IntroductionAlthough pulmonary arteriovenous malformations are relatively rare disorders, they are an important part of the differential diagnosis of common pulmonary problems, such as hypoxemia, dyspnea on exertion and pulmonary nodules.Case presentationAn 11-year-old Croatian boy of Mediterranean origin with a history of asthma since childhood was admitted to our hospital for evaluation of difficult-to-control asthma during the previous six months. A chest X-ray showed a homogeneous soft tissue mass in the lingual area. Computed tomography angiography of the thorax showed two pulmonary arteriovenous malformations, one on each side of the lungs. Diagnosis of hereditary hemorrhagic telangiectasia was made clinically by Curaçao criteria. Genetic analysis revealed a mutation in the endoglin gene. The patient was treated with embolotherapy with good clinical outcome.ConclusionWe present a case of pulmonary arteriovenous malformations masquerading as refractory asthma.

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Section: Discussionmentioning

confidence: 99%

Pulmonary arteriovenous malformations presenting as difficult-to-control asthma: a case report

et al. 2013

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“…In addition to these series, there have been case reports of HHT complications during pregnancy: PAVM‐related haemorrhage, 14–20 and growth of PAVMs 13,15,16,21,22 have been reported during pregnancy. HHT‐related cerebral AVMs have presented or haemorrhaged in the third trimester 23–25 .…”

Section: Introductionmentioning

confidence: 99%

Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler–Weber–Rendu syndrome): suggested approach for obstetric services

Shovlin¹,

Sodhi²,

McCarthy³

et al. 2008

BJOG

159

204

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Objectives Hereditary haemorrhagic telangiectasia (HHT) affects 1 in 5-8000 individuals. Pregnancy outcomes are rarely reported. The major reason is that most women do not have their HHT diagnosed prior to pregnancy. Using a large well-characterised series, we studied all pregnancies known to have occurred in HHTaffected women, whether or not their diagnosis was known at the time of pregnancy. Our aim was to estimate rates and types of major complications of HHT in pregnancy, to guide management decisions.Design Cohort study, with prospective, retrospective and familial components.Setting/Population Tertiary referral centre population.Methods All 262 pregnancies in the 111 women with HHT and pulmonary arteriovenous malformations (PAVMs) reviewed between 1999 and 2005 were studied. Eighty-two women (74%) did not have a diagnosis of HHT/PAVM at the time of pregnancy. 222 pregnancies in their 86 HHT-affected relatives were also studied.Main outcome measures PAVM bleed, stroke and maternal death.Results Thirteen women experienced life-threatening events during pregnancy: 1.0% (95% CI 0.1-1.9) of pregnancies resulted in a major PAVM bleed; 1.2% (0.3-2.2%) in stroke (not all were HHT related); and 1.0% (0.13-1.9%) in maternal death. All deaths occurred in women previously considered well. In women experiencing a life-threatening event, prior awareness of HHT or PAVM diagnosis was associated with improved survival (P = 0.041, Fisher's exact test).Conclusions Most HHT pregnancies proceed normally. Rare major complications, and improved survival outcome following prior recognition, means that pregnancy in a woman with HHT should be considered high risk. Recommendations for pregnancy management are provided.Keywords Arteriovenous malformations, cerebral, haemorrhage, myocardial infarction, nose bleeds, pulmonary.Please cite this paper as: Shovlin C, Sodhi V, McCarthy A, Lasjaunias P, Jackson J, Sheppard M. Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): suggested approach for obstetric services.

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“…21 In patients with HHT there are often multiple pulmonary AVMs, which generally grow more rapidly and produce more complications than in patients without HHT. 22 Few studies are available that estimate the prevalence of pulmonary AVMs in HHT patients using adequate methods. Lesca et al 23 reported a prevalence of 23.1% of pulmonary AVMs in 199 patients with genetically confirmed HHT.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic management of parturients with hereditary haemorrhagic telangiectasia for caesarean section

Shobary¹,

Schricker²,

Kaufman³

2009

International Journal of Obstetric Anesthesia

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Acute Hemothorax Owing to Pulmonary Arteriovenous Malformation in Pregnancy

Cited by 15 publications

References 0 publications

Pulmonary arteriovenous malformations presenting as difficult-to-control asthma: a case report

Pulmonary arteriovenous malformations presenting as difficult-to-control asthma: a case report

Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler–Weber–Rendu syndrome): suggested approach for obstetric services

Anaesthetic management of parturients with hereditary haemorrhagic telangiectasia for caesarean section

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