Acute Hemorrhage and Necrosis of the Intestines Associated with Digitalization

Gazes, Peter C.; Holmes, C. R.; Moseley, Vince; Pratt-Thomas, H.R.

doi:10.1161/01.cir.23.3.358

Cited by 90 publications

(18 citation statements)

References 10 publications

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“…The incidence of this disease among the adult patients examined post mortem was 4 six other patients no occlusion was found in the mesenteric vessels at surgery. Two of these were explored for massive rectal bleeding; in one, pinpoint hemorrhages were noted in the stomach and jejunum, and, in the other, blood found in the colon was thought to be originating in sigmoid diverticula.…”

Section: Clinical Aspectsmentioning

confidence: 82%

Hemorrhagic Necrosis of the Gastrointestinal Tract and Its Relation to Cardiovascular Status

Ming

1965

Circulation

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Seventy-five cases of hemorrhagic necrosis of the gastrointestinal tract were analyzed and compared with the entire autopsy population as control. The disease occurred most frequently in association with shock, which was present in 80 per cent of the cases with the gastrointestinal lesions. The incidence of heart disease was higher in the cases of hemorrhagic necrosis than in the control group. The role of cardiac dysfunction in the etiology of hemorrhagic necrosis is emphasized as are the roles played by the bacterial toxins and shock. All three conditions have been shown to result in marked reduction of the intestinal blood flow and venous stasis. Hemorrhagic necrosis of the gastrointestinal tract probably represents a conglomeration of microinfarcts of the mucosa secondary to markedly decreased local blood flow. Vasopressor agents have produced no beneficial effect; the effect of vasodilators remains to be determined.

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Section: Clinical Aspectsmentioning

confidence: 82%

Hemorrhagic Necrosis of the Gastrointestinal Tract and Its Relation to Cardiovascular Status

Ming

1965

Circulation

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“…In 2 cases, symptoms resolved after withdrawal of digitalis and were attributed to splanchnic vsoconstriction induced by the drug [3,4,13], 1 case required a bypass procedure [5]. Only 1 of our patients was on digoxin at the time of admission.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric Ischemia in Chronic Dialysis Patients

Dahlberg¹,

Kisken²,

Newcomer³

et al. 1985

Am J Nephrol

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6 chronic dialysis patients with acute mesenteric ischemia are described. 3 had nonocclusive infarctions, and 3 had occlusive disease. 5 of the patients had episodes of severe hypotension or hypovolemia immediately before the onset of abdominal symptoms. All patients had leukocyte counts of greater than 12,000 on admission, and 4 had stools positive for occult blood. The characterisitc features of dialysis-induced hypotenison followed by nonspecific abdominal symptoms and leukocytosis are emphasized.

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“…The mean values of both flow measurements and of both resistance calculations following glucagon administration were similar to the values found before injection of digoxin. Glucagon administration, as could be expected, produced a transient fall in systemic arterial pressure lasting [10][11][12][13][14][15] …”

Section: Glucagon Administrationmentioning

confidence: 99%