Acute Hemobilia and Hemocholecyst in 2 Dogs with Gallbladder Carcinoid

Lippo, N.J.; Williams, Julia; Brawer, Robert S.; Sobel, Keith E.

doi:10.1111/j.1939-1676.2008.0156.x

Cited by 24 publications

(32 citation statements)

References 14 publications

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“…This type of neoplasm in the gallbladder is not related to specific clinical signs. However, anorexia, ascites, weight loss, diarrhea, jaundice, vomiting, abdominalgia and hematemesis was described in animals with carcinoids of the hepatobiliary system (PATNAIK et al, 1981;WILLARD et al, 1988;MORRELL et al, 2002;BIRETTONI et al, 2008;LIPPO et al, 2008). Dogs in the present study had a clinical history of prostration, diarrhea and vomiting, in addition to abdominal pain, but these findings may be related to the splenic tumor lesions, especially in case 2.…”

mentioning

confidence: 49%

“…In the present study, the breeds affected were the Shih Tzu and the Cocker Spaniel. Current literature described cases in the Bullmastiff, Beagle, and Rhodesian ridgeback, in addition to two non-breed dogs (WILLARD et al, 1988;MORRELL et al, 2002;BIRETTONI et al, 2008;LIPPO et al, 2008). However, since gallbladder neoplasms are rare in dogs, and a limited number of cases are described in the literature, there is insufficient information to accurately associate predisposition with breed, age, or sex (CULLEN, 2017).…”

mentioning

confidence: 99%

“…Hepatobiliary carcinoids may show increased activity of liver enzymes, such as ALT and ALP (MORRELL et al, 2002;LIPPO et al, 2008). The increase in ALP in case 1 may be related to obstructive hepatic injury, due to neoformation, with a consequent decrease in biliary excretion of this enzyme (ALLISON, 2012).…”

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confidence: 99%

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Carcinoid of the gallbladder in two dogs

et al. 2020

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A carcinoid is a rare neoplasm derived from neuroendocrine cells that may arise in the hepatobiliary system. This report described two cases of carcinoid of the gallbladder in dogs, with emphasis on the clinical, pathological and immunohistochemical aspects. Case 1 was a 10-year-old female Shih Tzu, with a history of prostration and occasional episodes of diarrhea and vomiting. Case 2 was a 10-year-old male Cocker Spaniel, with a history of diarrhea and abdominal pain. Abdominal ultrasonography suggested a neoplasm of the gallbladder in both cases. The dogs underwent cholecystectomy, and 10% formalin-fixed samples were sent for pathological examination. Histologically, a neoplastic proliferation of neuroendocrine cells was observed in the gallbladder submucosa of both cases. Immunohistochemical labeling for neuroendocrine antibodies, such as synaptophysin, neuron-specific enolase and chromogranin A, confirmed the diagnoses. Carcinoid of the gallbladder is a rare neoplasm in dogs, without specific clinical signs, but should be included in the differential diagnosis of lesions that affect this organ.

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Carcinoid of the gallbladder in two dogs

et al. 2020

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“…The dog in this case had an intense acute anemia that could have been associated with the blood loss from the pancreas, although hematochezia was only observed on the day of the animal's death. Other causes of gastrointestinal hemorrhage that were not observed in the present report include hemobilia (16), angiodysplasia (5), hypoadrenocisticism (18), hemostasis disorders (17,21,29), intestinal neoplasia (32), foreign bodies (8), gastrointestinal ulcers (28), and gastroenteritis caused by viruses (3) and bacteria (23). These etiologies should be considered as differential diagnoses for HP.…”

Section: Discussionmentioning

confidence: 65%

“…HP can be caused by acute and chronic pancreatitis of primary or secondary origin (2,16,22,25), as well as primary or metastatic neoplasia (13,14,15,), pancreatic duct stones (10), vascular malformations, or splenic or celiac artery aneurysm (6,33). It has also been described as a clinical complication after pancreatic stent implants (29), abdominal trauma (11), iatrogenic causes (27) and pancreatic panniculitis (9).…”

Section: Introductionmentioning

confidence: 99%

Hemosuccus pancreaticus in a dog: A rare case of gastrointestinal hemorrhage

Botelho¹,

Moreira²,

Eckstein³

et al. 2018

BJVP

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A 9-year-old, 5.5-kg (12.12-lb) spayed female Poodle was evaluated due to recurrent seizures and possible diabetes. The dog also had a history of anorexia, polyuria and polydipsia. Serum biochemistry results revealed increases in pancreatic amylase and glucose associated with decreased protein levels. Abdominal ultrasound suggested acute pancreatitis and/or a pancreatic tumor with intense peripancreatic vascularization. The clinical condition of the dog worsened despite medical treatment, and death occurred shortly thereafter. At necropsy, blood clots were found in the stomach and in the intestinal lumen, which was filled with undigested blood. The pancreas was moderately increased in size with an irregular surface and multifocal yellow firm areas. In the cranial portion of the pancreas, a single nodule, approximately 2 cm in diameter, was found. Histologic evaluation of the pancreas revealed chronic and acute lesions characterized by lymphohistiocytic pancreatitis, periductal fibrosis, degeneration of pancreatic islets and necrotizing and fibrinopurulent pancreatitis. The nodule was diagnosed as pancreatic adenocarcinoma. These clinical, imaging, and histopathologic findings were compatible with Hemosuccus pancreaticus. To the authors' knowledge, this is the first report of Hemosuccus pancreaticus in a dog and it should be considered as a differential diagnosis for dogs with pancreatic disease and gastrointestinal bleeding.

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Liver Tumors and Partial Hepatectomy

Degner¹,

Walshaw²

2012

Small Animal Soft Tissue Surgery

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Acute Hemobilia and Hemocholecyst in 2 Dogs with Gallbladder Carcinoid

Cited by 24 publications

References 14 publications

Carcinoid of the gallbladder in two dogs

Carcinoid of the gallbladder in two dogs

Hemosuccus pancreaticus in a dog: A rare case of gastrointestinal hemorrhage

Liver Tumors and Partial Hepatectomy

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