Acute Hemichorea‐Hemiballismus Following <scp>COVID</scp>‐19 (<scp>AZD1222</scp>) Vaccination

Matar, Elie; Manser, David; Spies, Judith M.; Worthington, John; Parratt, Kaitlyn

doi:10.1002/mds.28796

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…First, oligoclonal bands, an inflammatory marker which can be found in some dysimmune chorea, were present in the CSF [14,15]. Second, intravenous corticosteroids resulted in clinical improvements, which has also been described in other dysimmune chorea [13,16,17]. Lastly, the fact that a COVID-19 vaccination had been performed 21 days earlier, which could have triggered a dysimmune reaction.…”

Section: Liver Ultrasoundmentioning

confidence: 79%

“…Chronic hepatopathy, normal biliary tracts been reported in elderly patients: an 83-year-old patient following Pfizer Bio-N-Tech COVID-19 vaccination [12], and two patients aged 88 and 84, respectively, following the ChAdOx1 nCoV-19 (AZD1222; AstraZeneca) vaccine [13]. Moreover, according to the Vigilyze pharmacovigilance database, around 40 cases of hemichorea and hemiballismus were reported following Pfizer Bio-N-Tech COVID-19 vaccination worldwide, remaining a rare event.…”

Section: Liver Ultrasoundmentioning

confidence: 99%

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Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

Batot¹,

Chea²,

Zeidan³

et al. 2022

Tremor and Other Hyperkinetic Movements

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Background: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder.Case Report: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET.Discussion: This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction.

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Section: Liver Ultrasoundmentioning

confidence: 79%

Section: Liver Ultrasoundmentioning

confidence: 99%

Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

Batot¹,

Chea²,

Zeidan³

et al. 2022

Tremor and Other Hyperkinetic Movements

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“…The pathophysiology of hemichorea in these cases is not clear, but several theories have been described for hemichorea after COVID‐19 vaccination. These include focal immune‐mediated endotheliopathy induced by the spike protein 2 and functional disturbance in contralateral thalamus, which was confirmed by single‐photon emission computed tomography. 3 …”

mentioning

confidence: 76%

“…Three cases with hemichorea have been reported previously, 2 after AZD1222 vaccination and 1 after Pfizer‐BioNTech COVID‐19 vaccination, but all reported patients were in their 80s. 2 , 3 …”

mentioning

confidence: 99%

Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Salari

Etemadifar

2022

Movement Disorders

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“…A total of eight patients (four women and four men, aged 36-77 years, mean 61) with COVID-19 [60][61][62][63][64][65][66] and an additional seven patients as an adverse event after vaccination against SARS-CoV-2 [67][68][69][70][71] (six men and one woman aged 13-90) have been reported to develop chorea (Tab. 2).…”

Section: Choreamentioning

confidence: 99%

Hyperkinetic movement disorders following SARS-CoV-2 infection and vaccination — an update

Przytuła¹,

Sławek

2023

Neurol Neurochir Pol.

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The aim of this review was to summarise current knowledge regarding hyperkinetic movement disorders related to SARS-CoV-2 infection and vaccination in terms of phenomenology, epidemiology, pathogenesis and treatment. After a thorough review of the PubMed and Google Scholar databases (2020-2022), we identified myoclonus and ataxia sometimes accompanied by opsoclonus (AMS) as the two most frequent COVID-19 sequelae, with chorea, tremor and dystonia being very rare. The pathogenesis seems to be variable, but in the majority of AMS cases it was autoimmunological, with good response and recovery after corticosteroids or intravenous immunoglobulins infusions. Vaccination may be complicated by hyperkinetic movement disorders (e.g. tremor, dystonia), but this is very rare. Patients with Deep Brain Simulation depletion should not be postponed due to lockdowns as this may result in fatal outcomes.

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Acute Hemichorea‐Hemiballismus Following COVID‐19 (AZD1222) Vaccination

Cited by 13 publications

References 7 publications

Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Hyperkinetic movement disorders following SARS-CoV-2 infection and vaccination — an update

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