Acute hematogenous osteomyelitis in intravenous drug users

Fox, Ira M.; Brady, Kervin

doi:10.1016/s1067-2516(97)80077-4

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…Opioid addicts, especially injecting heroin users, suffer increased health problems [ 1 - 3 ] and reduced health related quality of life (HRQOL) [ 4 - 7 ] as well as increased mortality, compared to the general population [ 8 - 10 ]. This is particularly related to overdoses [ 11 - 14 ], injuries [ 9 ], human immunodeficiency virus (HIV)-infection [ 9 , 11 ], viral hepatitis B (HBV) [ 15 , 16 ] and viral hepatitis C (HCV) [ 16 , 17 ] with end-state liver disease and other infections like endocarditis [ 9 ], osteomyelitis [ 18 ] and others [ 19 , 20 ]. Several studies and case reports demonstrate vulnerability among injecting drug users (IDUs) to rare infectious diseases like tetanus [ 21 ], botulism [ 22 , 23 ] and gas gangrene due to Clostridium [ 21 , 24 - 27 ].…”

Section: Introductionmentioning

confidence: 99%

Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study

et al. 2008

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Background: The long-term impact of opioid maintenance treatment (OMT) on morbidity and health care utilization among heroin addicts has been insufficiently studied. The objective of this study was to investigate whether health care utilization due to somatic disease decreased during OMT, and if so, whether the reduction included all kinds of diseases and whether a reduction was related to abstinence from drug use.

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Section: Introductionmentioning

confidence: 99%

Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study

et al. 2008

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“… 5 , 6 Osteomyelitis, prosthetic joint infections, septic arthritis, and epidural abscesses commonly occur in this population and with an increased risk of clinical complications; the treatment of these conditions often requires prolonged antibiotic treatment in addition to surgical intervention. 7 8 9 10 11 …”

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confidence: 99%

Outcomes of Orthopaedic Infections in Recreational Intravenous Drug Users Requiring Long-term Antibiotic Treatment

et al. 2022

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Patients who participate in recreational injection drug use (RIVDU) have an increased risk of orthopaedic infections requiring prolonged treatment with intravenous antibiotics. This study reviews clinical outcomes and complications in RIVDU and have orthopaedic infections requiring long term antibiotic therapy (.4 weeks) and compares these outcomes to non-RIVDU patients. In this retrospective review, patients were divided into cohorts based on RIVDU history; the RIVDU cohort was further divided into subcohorts based on treatment location. Cohorts and subcohorts were compared to evaluate clinical outcomes. Between the two main cohorts, there was a statistically significant difference in treatment compliance (P = 0.0012) and no statistically significant differences for infection resolution at 6-or 12-month follow-up, hospital readmission, or mortality. At the 6-month follow-up, RIVDU patients who remained inpatient had 100% resolution of infection, which was significantly better than the resolution of all other cohorts (P = 0.0019). No differences were observed between the remaining subcohorts for resolution of infection by 12 months, catheter complications, or loss to follow-up. Our findings demonstrate an increased rate of failure in outpatient parenteral antibiotic therapy in RIVDU patients, and this population has better clinical outcomes when they remain inpatient for the duration of treatment. Recreational intravenous (IV) drug use (RIVDU) is prevalent in society with an estimated 13 million people using injectable drugs globally. 1 People who inject drugs have an increased risk of premature mortality from drug overdose, suicide, and complications of HIV. [2][3][4] In addition, this demographic has an increased prevalence of many types of infections including hepatitis, skin and soft-tissue infections, and bone and joint infections. 5,6 Osteomyelitis, prosthetic joint infections, septic arthritis, and epidural abscesses commonly occur in this population and with an increased

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“…Οξεία Αιµατογενής Οστεοµυελίτιδα Η οξεία αιµατογενής οστεοµυελίτιδα των µακρών οστών έχει υψηλότερη επίπτωση στα παιδιά προεφηβικής ηλικίας, σε ηλικιωµένους ασθενείς, σε χρήστες ενδοφλέβιων ναρκωτικών και σε ασθενείς µε κεντρικούς φλεβικούς καθετήρες [32][33][34].…”

Section: εικόνα 1 αποικία σταφυλοκόκκων σε βιολογική µεµβράνη (Biofilm)unclassified

“…Συχνά µικροβιακά αίτια είναι η οµάδα των στρεπτοκόκκων της οµάδας Β και το κολοβακτηρίδιο. Σε ενήλικες ασθενείς που φέρουν για µεγάλο διάστηµα ενδοφλέβιους καθετήρες όπως και σε χρήστες ενδοφλέβιων ναρκωτικών ουσιών συχνότερα αίτια οξείας αιµατογενούς οστεοµυελίτιδας είναι ο χρυσίζων σταφυλόκοκκος, η ψευδοµονάδα και η κάντιντα [33].…”

Section: εικόνα 1 αποικία σταφυλοκόκκων σε βιολογική µεµβράνη (Biofilm)unclassified

Συγκριτική Μελέτη Ιστικής Κατανομής Των Αντιμικροβιακών Ουσιών Λινεζολίδη Λεβοφλοξασίνη Μοξιφλοξασίνη Στα Οστά Και Τις Αρθρώσεις

Metallidis¹,

Μεταλλίδης²

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Staphylococcus aureus MSSA Oxacillin 2g κάθε 6 ώρες ενδοφλέβια Cefazolin, vancomycin, clindamycin Staphylococcus aureus MRSA Vancomycin 1g κάθε 12 ώρες TMP/SMX, rifampin Streptococcus pneumoniae Penicillin G 5 x 10 6 κάθε 6 ώρες iv* Cefazolin, vancomycin, clindamycin Group A b-hemolytic streptococci Penicillin G 5 x 10 6 κάθε 8 ώρες iv Cefazolin, vancomycin, clindamycin Enterococci Ampicillin 2g κάθε 4 ώρες iv ! Vancomycin Haempophilus infuenzae (b-lactamase negative) Ampicillin 2g κάθε 4 ώρες iv TMP/SMX, Ceftriaxone Haempophilus infuenzae (b-lactamase positive) Ceftriaxone 1g κάθε 12 ώρες iv TMP/SMX Kliebsella pneumoniae Ceftriaxone 1g κάθε 12 ώρες iv Ciprofloxacin, piperacillin, imipenem Escherichia coli Cefazolin 1g κάθε 8 ώρες iv Ciprofloxacin, Ceftriaxone, imipenem

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Acute hematogenous osteomyelitis in intravenous drug users

Cited by 8 publications

References 13 publications

Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study

Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study

Outcomes of Orthopaedic Infections in Recreational Intravenous Drug Users Requiring Long-term Antibiotic Treatment

Συγκριτική Μελέτη Ιστικής Κατανομής Των Αντιμικροβιακών Ουσιών Λινεζολίδη Λεβοφλοξασίνη Μοξιφλοξασίνη Στα Οστά Και Τις Αρθρώσεις

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