Acute hearing loss in patients with hematological disorders

Lin, Chien-Yu; Chiang, Ching-Wen; Young, Yi‐Ho

doi:10.3109/00016489.2015.1015608

Cited by 6 publications

(6 citation statements)

References 19 publications

(27 reference statements)

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“…Previous studies have suggested an association between anemia and hearing loss [25][26][27]. In one study, the authors described 12 cases of SSNHL in 14 patients with leukemia or aplastic anemia [25]. A prospective cross-sectional study reported that 11.2% (10/89) of patients with sickle cell anemia had hearing loss [26].…”

Section: Discussionmentioning

confidence: 99%

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Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

Kim

Wee

Min

et al. 2020

IJERPH

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Previous studies have suggested an association of anemia with hearing loss. The aim of this study was to investigate the association of nutritional anemia with sudden sensorineural hearing loss (SSNHL), as previous studies in this aspect are lacking. We analyzed data from the Korean National Health Insurance Service-Health Screening Cohort 2002–2015. Patients with SSNHL (n = 9393) were paired with 37,572 age-, sex-, income-, and region of residence-matched controls. Both groups were assessed for a history of nutritional anemia. Conditional logistic regression analyses were performed to calculate the odds ratios (ORs) (95% confidence interval, CI) for a previous diagnosis of nutritional anemia and for the hemoglobin level in patients with SSNHL. Subgroup analyses were conducted for age and sex. Age, sex, income, and region of residence were stratified. Obesity, smoking, drinking alcohol, systolic/diastolic blood pressure, fasting blood glucose, total cholesterol, and the Charlson Comorbidity Index were considered in the regression models. Nutritional anemia was present in 4.8% (449/9393) of patients with SSNHL and 4.0% (1494/37,572) of controls (p < 0.001). The SSNHL group demonstrated 1.20-fold higher odds for nutritional anemia (95% CI = 1.08–1.34, p = 0.001). Hemoglobin levels were not associated with SSNHL. In subgroups <60 years old, there was a consistent positive association of nutritional anemia with SSNHL (adjusted OR = 1.55, 95% CI = 1.11–2.15, p = 0.010 for men <60 years old, and adjusted OR = 1.22, 95% CI = 1.02–1.45, p = 0.028 for women <60 years old). Nutritional anemia, but not hemoglobin level, was associated with an increased risk of SSNHL.

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Section: Discussionmentioning

confidence: 99%

“…Another theory is that biochemical and electrical imbalances in the inner ear of anemic patients could result in endolymphatic hydrops and SSNHL. A few previous studies have reported endolymphatic hydrops in patients with hematologic disorders such as anemia or leukemia [25,33].…”

Section: Discussionmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

Kim

Wee

Min

et al. 2020

IJERPH

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“…Hematological disorders such as aplastic anemia, sickle cell anemia, and hyperviscosity syndrome have been described as being associated with inner ear deficits. These hematological diseases may cause inner ear hemorrhage or vasculopathy ( 53 ).…”

Section: Etiological Comorbiditiesmentioning

confidence: 99%

“…Lin et al ( 53 ) reported that during the 20 years, they had identified 14 cases of SSNHL among patients with hematological disorders, i.e., leukemia or aplastic anemia. Most of these patients presented an abnormal mean hearing level, cervical vestibular-evoked myogenic potential test, ocular vestibular-evoked myogenic potential test, and caloric test results, exhibiting a significant sequential decline in inner ear function.…”

Section: Etiological Comorbiditiesmentioning

confidence: 99%

Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review

et al. 2023

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Sudden sensorineural hearing loss (SSNHL) is defined as an abrupt hearing loss of more than 30 dB in three contiguous frequencies within 72 h. It is an emergency disease requiring immediate diagnosis and treatment. The incidence of SSNHL in Western countries' population is estimated between 5 and 20 per 1,00,000 inhabitants. The etiology of SSNHL remains unknown. Due to the uncertainty of the cause of SSNHL, at present, no specific treatment targets the cause of SSNHL, resulting in poor efficacy. Previous studies have reported that some comorbidities are risk factors for SSNHL, and some laboratory results may provide some clues for the etiology of SSNHL. Atherosclerosis, microthrombosis, inflammation, and the immune system may be the main etiological factors for SSNHL. This study confirms that SSNHL is a multifactorial disease. Some comorbidities, such as virus infections, are suggested to be the causes of SSNHL. In summary, by analyzing the etiology of SSNHL, more targeting treatments should be used to achieve a better effect.

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“…Since then, it has become apparent that otologic manifestations of hematologic malignancies are common, with a reported incidence of 32% to 69% in patients with leukemia (3)(4)(5). While the incidence of otologic symptoms in patients with lymphoma has not been addressed in the literature, symptoms have included those of serous otitis media, conductive hearing loss, otalgia, and aural fullness (6)(7)(8). The incidence of otologic symptoms secondary to multiple myeloma is also unknown but isolated reports have found asso-ciations with hearing loss and vertigo (9,10).…”

Section: Introductionmentioning

confidence: 99%

A Scoping Review of Otologic Manifestations of Hematologic Malignancies

Raymond,

Ottinger,

Rowley

et al. 2024

Otol Neurotol

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Objective To examine the otologic and neurotologic symptoms, physical examination findings, and imaging features secondary to hematologic malignancies. Methods Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, databases, including PubMed, Scopus, and CINAHL, were searched for articles including patients with otologic manifestations of leukemia, lymphoma and multiple myeloma. Data collected included patient and study demographics, specific hematologic malignancy, timing and classification of otologic symptoms, physical examination findings, imaging features and methods of diagnosis. Pooled descriptive analysis was performed. Results Two hundred seventy-two articles, of which 255 (93.8%) were case reports and 17 (6.2%) were case series, reporting on 553 patients were identified. Otologic manifestations were reported on 307 patients with leukemia, 204 patients with lymphoma and 42 patients with multiple myeloma. Hearing loss and unilateral facial palsy were the most common presenting symptoms for 111 reported subjects with leukemia (n = 46, 41.4%; n = 43, 38.7%) and 90 with lymphoma (n = 38, 42.2%; n = 39, 43.3%). Hearing loss and otalgia were the most common presenting symptoms for 21 subjects with multiple myeloma (n = 10, 47.6%; n = 6, 28.6%). Hearing loss and unilateral facial palsy were the most common otologic symptoms indicative of relapse in subjects with leukemia (n = 14, 43.8%) and lymphoma (n = 5, 50%). Conclusion Hearing loss, facial palsy, and otalgia might be the first indication of a new diagnosis or relapse of leukemia, lymphoma, or multiple myeloma. Clinicians should have a heightened level of suspicion of malignant etiologies of otologic symptoms in patients with current or medical histories of these malignancies.

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Acute hearing loss in patients with hematological disorders

Cited by 6 publications

References 19 publications

Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review

A Scoping Review of Otologic Manifestations of Hematologic Malignancies

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