Acute haemolysis due to concentrated dialysis fluid.

Mulligan, I.P.; Parfrey, Patrick S.; Phillips, M. E.; Brown, Ellen; Curtis, J. R.

doi:10.1136/bmj.284.6323.1151

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…In many extracorporeal blood purification systems, the blood is brought in near contact with an isotonic aqueous solution through a semipermeable membrane. Changes in blood pH, toxic substances (1), or high temperature (2) can be induced by this close contact and are known causes for hemolysis. Most of these risks have disappeared today through the introduction of appropriate safety measures in the dialysis machines.…”

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confidence: 99%

Numerical Calculation of Hemolysis Levels in Peripheral Hemodialysis Cannulas

Wachter

Verdonck

2002

Artificial Organs

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Hemolysis in extracorporeal life support systems presents an underestimated problem. In this article, we investigate the hemolytic potential of peripheral hemodialysis cannulas numerically. An axisymmetrical finite element model of 3 cannula sizes was built (13G, 14G, and 16G) that was refined sufficiently in the vicinity of the cannula tip to compute accurately scalar shear stresses. Scalar shear stresses were utilized in Giersiepen's equation to calculate the red blood cell damage (RBD) along streamlines. The streamlines were chosen such that they bound a percentage of the blood flow through the cannula. By integration of the RBD results, the total damage of the cannula was determined and expressed in modified index of hemolysis for comparison with published results. Calculated RBD was overestimated by Giersiepen's equation. The ranking of the cannulas according to their hemolytic potential was preserved. This indicates that power-law equations may be suited for hemolysis prediction of laminar flow devices.

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Numerical Calculation of Hemolysis Levels in Peripheral Hemodialysis Cannulas

Wachter

Verdonck

2002

Artificial Organs

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“…However, blood hemolysis associated with the interaction between the blood and the rotating blades must be carefully considered. Although there are many factors that relate to the blood hemolysis such as the blood pH, toxic ingredients, and temperature (3,4), it has been well established that blood hemolysis that occurred in a rotational heart pump is mainly caused by the mechanical hematocyte damage related to the inner flow dynamics (5,6).…”

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Numerical Study of a Bio‐Centrifugal Blood Pump With Straight Impeller Blade Profiles

2010

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Computational fluid dynamic simulations of the flow in the Kyoto-NTN (Kyoto University, Kyoto, Japan) magnetically suspended centrifugal blood pump with a 16-straight-bladed impeller were performed in the present study. The flow in the pump was assumed as unsteady and turbulent, and blood was treated as a Newtonian fluid. At the impeller rotating speed of 2000 rpm and flow rate of 5 L/min, the pump produces a pressure head of 113.5 mm Hg according to the simulation. It was found that the double volute of the pump has caused symmetrical pressure distribution in the volute passages and subsequently caused symmetrical flow patterns in the blade channels. Due to the tangentially increasing pressure in the volute passages, the flow through the blade channels initially increases at the low-pressure region and then decreases due to the increased pressure. The reverse flow and vortices have been identified in the impeller blade channels. The high shear stress of the flow in the pump mainly occurred at the inlet and outlet of the blade channels, the beginning of the volute passages and the regions around the tips of the cutwater and splitter plate. Higher shear stress is obtained when the tips of the cutwater and splitter plate are located at the impeller blade trailing edges than when they are located at the middle of the impeller blade channel. It was found that the blood damage index assessed based on the blood corpuscle path tracing of the present pump was about 0.94%, which has the same order of magnitude as those of the clinical centrifugal pumps reported in the literature.

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Hemodialysis machines and monitors

Polaschegg¹,

Levin²

2004

Replacement of Renal Function by Dialysis

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Acute haemolysis due to concentrated dialysis fluid.

Cited by 7 publications

References 4 publications

Numerical Calculation of Hemolysis Levels in Peripheral Hemodialysis Cannulas

Numerical Calculation of Hemolysis Levels in Peripheral Hemodialysis Cannulas

Numerical Study of a Bio‐Centrifugal Blood Pump With Straight Impeller Blade Profiles

Hemodialysis machines and monitors

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