Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial

Kerr, Jacqueline; Crist, Katie; Vital, Daniela G.; Dillon, Lindsay; Aden, Sabrina A.; Trivedi, Minaxi; Castellanos, Luis R.; Godbole, Suneeta; Li, Hongying; Allison, Matthew; Khemlina, Galina; Takemoto, Michelle; Schenk, Simon; Sallis, James F.; Grace, Megan S.; Dunstan, David W.; LaCroix, Andrea Z.; Sears, Dorothy D.

doi:10.1371/journal.pone.0188544

Cited by 28 publications

(96 citation statements)

References 34 publications

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“…Participants ranged from those with type 2 diabetes [15,47,60] to those who were healthy and had relatively high levels of CRF [7,8,45]. The number of participants in studies ranged from 9 [45,61] to 70 [62]. A total number of 620 participants were included in the meta-analysis for glucose outcomes, 523 for insulin outcomes and 360 for TAG outcomes.…”

Section: Pa Breaks Vs No-exercise Sittingmentioning

confidence: 99%

Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis

et al. 2019

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Background Physical activity (PA) breaks in sitting time might attenuate metabolic markers relevant to the prevention of type 2 diabetes. Objectives The primary aim of this paper was to systematically review and meta-analyse trials that compared the effects of breaking up prolonged sitting with bouts of PA throughout the day (INT) versus continuous sitting (SIT) on glucose, insulin and triacylglycerol (TAG) measures. A second aim was to compare the effects of INT versus continuous exercise (EX) on glucose, insulin and TAG measures. Methods The review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) recommendations. Eligibility criteria consisted of trials comparing INT vs. SIT or INT vs. one bout of EX before or after sitting, in participants aged 18 or above, who were classified as either metabolically healthy or impaired, but not with other major health conditions such as chronic obstructive pulmonary disease or peripheral arterial disease. Results A total of 42 studies were included in the overall review, whereas a total of 37 studies were included in the metaanalysis. There was a standardised mean difference (SMD) of − 0.54 (95% CI − 0.70, − 0.37, p = 0.00001) in favour of INT compared to SIT for glucose. With respect to insulin, there was an SMD of − 0.56 (95% CI − 0.74, − 0.38, p = 0.00001) in favour of INT. For TAG, there was an SMD of − 0.26 (95% CI − 0.44, − 0.09, p = 0.002) in favour of INT. Body mass index (BMI) was associated with glucose responses (β = − 0.05, 95% CI − 0.09, − 0.01, p = 0.01), and insulin (β = − 0.05, 95% CI − 0.10, − 0.006, p = 0.03), but not TAG (β = 0.02, 95% CI − 0.02, 0.06, p = 0.37). When energy expenditure was matched, there was an SMD of − 0.26 (95% CI − 0.50, − 0.02, p = 0.03) in favour of INT for glucose, but no statistically significant SMDs for insulin, i.e. 0.35 (95% CI − 0.37, 1.07, p = 0.35), or TAG i.e. 0.08 (95% CI − 0.22, 0.37, p = 0.62). It is worth noting that there was possible publication bias for TAG outcomes when PA breaks were compared with sitting. Conclusion The use of PA breaks during sitting moderately attenuated post-prandial glucose, insulin, and TAG, with greater glycaemic attenuation in people with higher BMI. There was a statistically significant small advantage for PA breaks over continuous exercise for attenuating glucose measures when exercise protocols were energy matched, but no statistically significant differences for insulin and TAG. PROSPERO Registration: CRD42017080982. PROSPERO Registration CRD42017080982. Key PointsBreaking up sitting with physical activity (PA) moderately attenuated post-prandial glucose and insulin, with a small effect size attenuation for TAG.There was greater glycaemic attenuation in people with higher body mass index (BMI).PA breaks were slightly more effective for glycaemic attenuation compared to one continuous bout of PA when experimental conditions were energy expenditure matched. Affiliations

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Section: Pa Breaks Vs No-exercise Sittingmentioning

confidence: 99%

Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis

et al. 2019

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“…Indeed, sitting has negative effects on postprandial glycemic metabolism ( 6 ) resulting in a decrease in lipoprotein lipase enzyme activity ( 7 ), which causes a reduction in triglyceride hydrolysis and a decreased glucose evacuation. On the other hand, standing allows a reduction of postprandial glucose and insulin; it is therefore sufficient to get up regularly (e.g., every 20 min) or to work standing ( 8 – 11 ) to avoid these effects. Consequently, standing cannot be considered as a sedentary behavior even if in the past it has been categorized as such ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Sedentary Behavior at Work and Cognitive Functioning: A Systematic Review

Magnon¹,

Vallet²,

Auxiette³

2018

Front. Public Health

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Background: It is now well-established that sedentarity has a negative impact on the physiological functioning and health of humans, whereas very little is known about the psychological repercussions, especially in cognitive functioning. Yet, studying the cognitive effects of the sedentary lifestyle is particularly relevant in the short term for productivity and in the long term for cognitive health (accelerated aging). This systematic review therefore aims to make an inventory of the potential cognitive effects of sedentarity at the workplace.Methods: Pubmed, PsycINFO, Cochrane, Web of Science, and Scopus were searched for English-language peer-reviewed articles published between January 1, 2000 and December 31, 2017 to identify studies including sedentary behavior and objective measures from cognitive domains (cognitive inhibition, cognitive flexibility, working memory, etc.). To carry out this systematic review, the 3 keywords “Sedentary” and “Cognition” and “Work” (and their derivatives) had to appear in the title or in the summary of the paper.Results: Of the 13 papers that met the inclusion criteria, 9 were short-term interventions, 3 medium-term interventions, and 1 long-term intervention. Nine of them reported non-significant results. Two studies study reported deterioration in cognitive performance. Two reported an improvement in performance in cognitive tasks with one study with overweight adults and the only one study with a long-term intervention. However, these studies intend to reduce sedentary behavior, but do not allow answering the question of the potential cognitive effects of the sedentary lifestyle.Conclusion: These data suggest that sedentary behavior is not associated with changes in cognitive performance in interventions that intend to reduce sedentary behavior. Then, and given the trend toward increased time in sedentary behavior, long-term prospective studies of high methodological quality are recommended to clarify the relationships between sedentary behavior and the cognitive functioning. Our systematic review identifies also the need for retrospective, longitudinal, or epidemiologic studies. It also recognizes the need to standardize methodology for collecting, defining, and reporting sedentary behavior and the need to standardize the cognitive tests used. The relationship between sedentary behavior and cognitive functioning remaining uncertain, further studies are warranted for which 8 recommendations are proposed.

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“…Three trials [18, 34, 58] recruited postmenopausal women (aged > 65 years) (Table 2) who were normal weight [58] or overweight [18, 34]. Only one trial presented data for stroke survivors who were 0.25 to 10 years post-stroke, older adults (68 ± 2 years) and overweight [20, 30].…”

Section: Resultsmentioning

confidence: 99%

“…Ten trials included measures of hypertension [14–16, 20, 30, 33, 34, 41, 42, 50, 52], 26 included measures of dysglycemia [12, 18–20, 30, 32–35, 37–41, 43–51, 53–58], one included measures of anthropometric risk factors [49], and four trials included measures of hypercholesterolemia [31, 32, 41, 43]. No trials presented behavioural, psychosocial or cardiac risk factors (Table 3).…”

Section: Resultsmentioning

confidence: 99%

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What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

et al. 2019

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The objective of this review was to ascertain the scope of the available literature on the effects of interrupting prolonged sitting time with frequent bouts of physical activity or standing on stroke and recurrent stroke risk factors. Databases Medline, Embase, AMED, CINAHL and Cochrane library were comprehensively searched from inception until 21 st February 2018. Experimental trials which interrupted sitting time with frequent bouts of physical activity or standing in adults (≥ 18 years) were included. Comparison to a bout of prolonged sitting and a measure of at least one first or recurrent stroke risk factor was required to be included. Overall, 30 trials (35 articles) were identified to meet the inclusion criteria. Fifteen trials were completed in participants at an increased risk of having a first stroke and one trial in participants at risk of a recurrent stroke. Outcomes of hypertension and dysglycemia were found to be more favourable following predominately light- to moderate-intensity bouts of physical activity or standing compared to sitting in the majority of trials in participants at risk of having a first stroke. In the one trial of stroke survivors, only outcomes of hypertension were significantly improved. These findings are of significant importance taking into consideration hypertension is the leading risk factor for first and recurrent stroke. However, trials primarily focused on measuring outcomes of dysglycemia and without assessing a dose-response effect. Additional research is required on the dose-response effect of interrupting sitting with frequent bouts of physical activity or standing on first and recurrent stroke risk factors, in those high risk population groups.

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Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial

Cited by 28 publications

References 34 publications

Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis

Effects of Interrupting Prolonged Sitting with Physical Activity Breaks on Blood Glucose, Insulin and Triacylglycerol Measures: A Systematic Review and Meta-analysis

Sedentary Behavior at Work and Cognitive Functioning: A Systematic Review

What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

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