Acute glomerulonephritis secondary to<i>Streptococcus anginosus</i>

Maharaj, Satish; Seegobin, Karan; Chrzanowski, Stephen M.; Chang, Simone

doi:10.1136/bcr-2017-223314

Cited by 6 publications

(4 citation statements)

References 19 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, when mediastinal abscesses occur, treatment is relatively difficult, and early active intervention should be taken to reduce the mortality. In addition, S. anginosus bacteremia can also contribute to other infections without abscess formation, such as infective endocarditis [ 16 ], osteomyelitis [ 17 ], gas gangrene [ 18 ], endogenous endophthalmitis [ 19 ], and acute glomerulonephritis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review

Zheng

2020

Open Medicine

View full text Add to dashboard Cite

Organ abscesses caused by Streptococcus anginosus are relatively rare. We report the case of an elderly woman with splenic abscess caused by S. anginosus bacteremia after urinary tract infection. An 82-year-old woman had a history of frequency of urination, urgency, and fever with chills for over 10 days prior to admission. An abdominal computed tomography (CT) scan performed in the emergency room revealed a low-density lesion in the spleen, kidney cysts, some exudation around the kidney, and cystitis should be valued. She was treated with ceftriaxone and imipenem/cilastatin. After admission, the blood culture yielded positive results for S. anginosus. A contrast-enhanced abdominal CT scan showed that the low-density lesion previously found in the spleen was smaller than before. After percutaneous drainage of the splenic abscess and treatment with piperacillin/tazobactam based on the antibiotic sensitivity pattern, repeated abdominal CT scan revealed a significant reduction in the low-density lesion. The patient was discharged without recurrence or complications. A systematic review of organ abscess caused by S. anginosus bacteremia was performed. To our knowledge, there has been no report of splenic abscess caused by S. anginosus bacteremia secondary to urinary system tract infection, although urinary tract infections are also an important source.

show abstract

Section: Discussionmentioning

confidence: 99%

Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review

Zheng

2020

Open Medicine

View full text Add to dashboard Cite

show abstract

“…Неиммунное [11,13], Streptococcus pneumonia [96,116], Streptococcus constellatus [10] и Streptococcus anginosus [77]. Идентификация стрептококкового антигена или антигенов, обладающих нефритогенной активностью, продолжает оставаться предметом споров и обсуждений до настоящего времени.…”

Section: аутоиммунные заболевания стрептококковой этиологииunclassified

Streptococcus pyogenes: phenomenon of nonimmune binding of human immunoglobulins and its role in pathology

2022

View full text Add to dashboard Cite

M and M-like proteins represent the main pathogenicity factors of Streptococcus pyogenes, a widely spread and potentially lethal bacterial pathogen. These proteins provide resistance of the microbe to innate and adaptive immune response, due to attraction of specific human proteins to the streptococcal surface. Nonimmune binding of immunoglobulins G (IgG) and A (IgA) via their Fc domains to M and M-like proteins was described over 40 years ago, but its role for the pathogenicity of Streptococcus pyogenes is far from definite resolution. The discovery of this phenomenon should be considered among quite significant achievements of modern microbiology, since it had a huge impact upon development of innovative approaches, technologies and tools for microbiological, immunological and molecular diagnostics. It also promoted fundamental studies in pathogenesis of distinct infectious states and their complications caused by S. pyogenes. The non-immune binding of host immunoglobulins was previously suggested to be important mainly in immune conditions on the surface of mucous membranes and their secretions, but not in blood plasma, whereas other studies have pointed to significance of this phenomenon in protecting microbes from phagocytosis in non-immune blood of the host. It was also shown that the effect of Fc-binding causes increased pathogenicity of streptococci both in primary focus of infection, and during chronical course of the process, thus contributing to development of autoimmune diseases caused by S. pyogenes infection and leading to tissue damage in experimental animals. The experimental autoimmune process can be prevented by administering purified Fc fragments of immunoglobulins to the animals, blocking this process at the early stages of its development. A significant place in pathogenesis of IgA nephropathy (IgAN) belongs to streptococcal diseases. IgAN has been described as a mesangial proliferative process, due to initial IgA-Fcα deposition in renal mesangium cells. The data from literature describe successful modeling of individual IgAN traits, and expand our understanding of pathogenic properties and functions of Fcα binding receptor M proteins of S. pyogenes. The data reviewed in the article also presume the relevance of recently proposed ideas about an important role of non-immune Ig binding in streptococcal diseases, even in cases that differ in their development mechanism. These studies, including possible search for tools and techniques of preventive and potentially therapeutic applications, require additional efforts to study the binding of Fc fragments of IgG and IgA to M and M-like proteins of Streptococcus pyogenes.

show abstract

“…Однако сегодня признано, что стрептококки группы А не обладают «монополией» на «нефритогенность». Исследования отдельных случаев и эпидемических вспышек показали, что гломерулонефрит может развиваться и после инфекций, вызываемых Streptococcus zooepidemicus [13,15], Streptococcus pneumoniae [73], Streptococcus constellatus [12] и Streptococcus anginosus [54].…”

Section: Introductionunclassified

Autoimmune streptococcal glomerulonephritis: the problem of nephritogenicity of <i>Streptococcus pyogenes</i>

Burova,

Suvorov,

Pigarevsky

et al. 2023

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

Acute post-streptococcal glomerulonephritis usually occurs as a complication after a streptococcal infection due to untimely or inadequate antibiotic therapy. The etiology of post-streptococcal glomerulonephritis has been studied rather comprehensively. Today, both clinicians and microbiologists do not deny the dominant role of Streptococcus pyogenes (streptococcus attributed to serological group A, GAS). Usually, emergence of acute post-streptococcal glomerulonephritis (APSGN) is associated with the so-called GAS-related "nephritogenicity" often judged by appearance and accumulation of antibodies to the antigens and extracellular products of streptococcal cells in patient blood. This interpretation is quite loose and most likely evidence about a link to the bacterial strain, rather than its nephritogenicity. Many studies refer and still attribute a leading role of "nephritogenic" factors to various streptococcal antigens and related biologically active products. Streptococcal nephritogenic factors include cross-reacting antigens, streptokinase, cysteine proteinase, endostreptosin a GAS cell membrane protein as well as plasmin-tropic enzyme glyceraldehyde-3-phosphate dehydrogenase. Nephritogenicity of all such streptococcal products is suspected to result from the fact that they are found in renal biopsies like specific patient blood serum antibodies. Regarding a term of nephritogenicity, it has been evidenced that it cannot be attributed to any specific streptococcal cell product. This review attempted to analyze a number of bacterial products as starting factors triggering this process. APSGN can be reproduced experimentally in rabbits by intravenous administration of a heat-killed Streptococcus pyogenes culture. In our experiments, strains of serotypes 1, 4, 12, 15, 22 were used. They produced M-proteins and had the ability to bind human and rabbit immunoglobulin G by interacting with the Fc part of the IgG molecule. In numerous series of experiments, evidence was obtained regarding the initiating role of GAS IgGFc-receptor proteins in developing APSGN. Recent studies confirmed the role of streptococcal IgGFc-binding proteins in the initiation of glomerulonephritis after animals were inoculated with temperature-killed IgGFc-positive GAS. This approach excluded a large group of bacterial extracellular agents from the list of APSGN-initiating candidates. An unconventional view on the pathogenesis of GAS-infection-coupled complications may allow approaching their prevention or new treatment strategies.

show abstract

Acute glomerulonephritis secondary toStreptococcus anginosus

Cited by 6 publications

References 19 publications

Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review

Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review

Streptococcus pyogenes: phenomenon of nonimmune binding of human immunoglobulins and its role in pathology

Autoimmune streptococcal glomerulonephritis: the problem of nephritogenicity of <i>Streptococcus pyogenes</i>

Contact Info

Product

Resources

About