Acute glomerulonephritis?changing patterns in Singapore children

Yap, Hui-Kim; Chia, Kee‐Seng; Murugasu, B; Saw, A. H.; Tay, J. S. H.; Ikshuvanam, Malati; Tan, K. L.; Cheng, Heng-Kok; Tan, C.Y.Y.; Lim, Cynthia Ciwei

doi:10.1007/bf00869825

Cited by 38 publications

(21 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Singapore, the incidence of APSGN has decreased due to a marked improvement in socioeconomic status and health care [11]. In Tennessee, USA, a marked decline in the prevalence of APSGN in an urban area was similarly reported with an increase incidence in rural populations with predominant antecedent pharyngitis in white children and predominant antecedent pyoderma in black children [12].…”

Section: Discussionmentioning

confidence: 85%

Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study

Ilyas

Tolaymat

2008

Pediatr Nephrol

View full text Add to dashboard Cite

The objective of this study was to review the epidemiological patterns of acute post-streptococcal glomerulonephritis (APSGN) in a pediatric population. We compared incidence, pathogenesis, clinical presentation and outcomes in two APSGN pediatric patient cohorts in northeastern Florida. Retrospective medical records were reviewed of children who were admitted to our institution with a diagnosis of APSGN. Patients admitted between 1999 and 2006 (recent cohort) were compared with a previously reported cohort of patients admitted between 1957 and 1973 (earlier cohort). The recent cohort comprised 45 children with APSGN of whom 87% were male and 13% were female; the median age was 7 years, and there was an average incidence of 6.4 patients per year. The earlier cohort comprised 153 children with APSGN of whom 62% were male and 38% were female; the median age 4.25 years, and there was an average incidence of 10.9 patients per year. The recent cohort was predominantly White-American (62%) and the earlier cohort predominately African American (87%). In the recent cohort, 64% of patients had antecedent pharyngitis, and in the earlier cohort, 66% of patients had antecedent pyoderma. In the recent cohort, 11% of APSGN cases occurred between August to October, and in the earlier cohort, 50% occurred during these months. In the recent cohort, symptoms of APSGN at presentation were milder and all cases recovered, but in the earlier cohort two deaths (1.3% mortality) were reported. In conclusion, there has been a decline in the incidence and severity of APSGN at our institute in recent decades. Pharyngitis has replaced impetigo as the predominant cause of APSGN. The etiological agent for impetigo has changed over the last decade, which has impacted the incidence, racial distribution, seasonal variation and severity of APSGN.

show abstract

Section: Discussionmentioning

confidence: 85%

Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study

Ilyas

Tolaymat

2008

Pediatr Nephrol

View full text Add to dashboard Cite

show abstract

“…Overcrowding, poor access to water and poverty have been associated with scabies and impetigo[1, 2, 9, 37], and indeed in our prospective analysis those patients from overcrowded households and remote Aboriginal communities had significantly increased odds of skin infection. As evidenced in the industrialisation of tropical countries such as Singapore, improvements in housing along with better access to quality healthcare can significantly impact on the burden of skin infection complications such as post-streptococcal glomerulonephritis[38]. …”

Section: Discussionmentioning

confidence: 99%

Are scabies and impetigo “normalised”? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections

et al. 2017

View full text Add to dashboard Cite

BackgroundComplications of scabies and impetigo such as glomerulonephritis and invasive bacterial infection in Australian Aboriginal children remain significant problems and the overall global burden of disease attributable to these skin infections remains high despite the availability of effective treatment. We hypothesised that one factor contributing to this high burden is that skin infection is under-recognised and hence under-treated, in settings where prevalence is high.MethodsWe conducted a prospective, cross-sectional study to assess the burden of scabies, impetigo, tinea and pediculosis in children admitted to two regional Australian hospitals from October 2015 to January 2016. A retrospective chart review of patients admitted in November 2014 (mid-point of the prospective data collection in the preceding year) was performed. Prevalence of documented skin infection was compared in the prospective and retrospective population to assess clinician recognition and treatment of skin infections.Results158 patients with median age 3.6 years, 74% Aboriginal, were prospectively recruited. 77 patient records were retrospectively reviewed. Scabies (8.2% vs 0.0%, OR N/A, p = 0.006) and impetigo (49.4% vs 19.5%, OR 4.0 (95% confidence interval [CI 2.1–7.7) were more prevalent in the prospective analysis. Skin examination was only documented in 45.5% of cases in the retrospective review. Patients in the prospective analysis were more likely to be prescribed specific treatment for skin infection compared with those in the retrospective review (31.6% vs 5.2%, OR 8.5 (95% CI 2.9–24.4).ConclusionsScabies and impetigo infections are under-recognised and hence under-treated by clinicians. Improving the recognition and treatment of skin infections by clinicians is a priority to reduce the high burden of skin infection and subsequent sequelae in paediatric populations where scabies and impetigo are endemic.

show abstract

“…Over the past 30 years, there has been a progressive decline in the incidence of acute post-streptococcal glomerulonephritis (APSGN) in developed countries [1][2][3][4][5]; however, among New Zealand children, APSGN is the commonest cause of acute glomerulonephritis. In a recent unpublished study undertaken between January 2006 to April 2007, 111 cases were identified in two children's inpatient facilities in Auckland, New Zealand, resulting in a mean annual admission rate of 30-62 per 100,000 children under the age of 14 years between these two centers.…”

Section: Introductionmentioning

confidence: 99%

Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children

2009

View full text Add to dashboard Cite

Post-streptococcal glomerulonephritis (PSGN) is the commonest cause of severe acute glomerulonephritis in New Zealand children, with the majority (85%) of the patients being of either Pacific Island or Maori ethnicity. We have performed a retrospective study on 27 pediatric patients with acute PSGN. Of these patients, those with crescentic glomerulonephritis (n = 11) had a greater tendency (72.7%) for needing acute dialysis and were left with persistent urinary sediment abnormalities after a mean follow-up of 3.2 years (95% confidence interval 2.1-4.3). The efficacy of immunosuppression in the group with crescentic disease was uncertain. The severity of renal histopathological abnormalities as judged by the total biopsy score did not correlate with either presentation or eventual outcome. Severe childhood acute post-streptococcal glomerulonephritis, although uncommon, results in significant long-term renal morbidity, particularly among Maori and Pacific Island children.

show abstract

Acute glomerulonephritis?changing patterns in Singapore children

Cited by 38 publications

References 7 publications

Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study

Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study

Are scabies and impetigo “normalised”? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections

Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children

Contact Info

Product

Resources

About