Acute gingival bleeding as a complication of dengue hemorrhagic fever

Khan, Saif; Gupta, Neha; Maheshwari, Sandhya

doi:10.4103/0972-124x.118328

Cited by 16 publications

(18 citation statements)

References 11 publications

(11 reference statements)

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“…It has been reported that glomerular capillary dilatation, haemorrhage into the interstitium, in small and large renal vessels occur during pathogenesis of fever [38], also acute gingival bleeding has been reported in fever especially in dengue hemorrhagic fever [39]. Vasodilation of the renal vasculature and gingival bleeding as a result of hyperthermia enhanced the detection of malaria antigens in urine and saliva in this study.…”

Section: Discussionsupporting

confidence: 60%

Evaluating the potential of using urine and saliva specimens for malaria diagnosis in suspected patients in Ghana

Aninagyei

Abraham

Atiiga

et al. 2020

Malar J

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Background This study aimed at detecting PfHRP2 and pLDH malaria antigens in urine and salivary specimens of suspected malaria patients using RDT kits, and identifying factors influencing the detection of these antigens. Methods Malaria rapid test kit (SD Bioline RDT kit) was used to detect malaria antigens, PfHRP2 and pLDH, in blood, urine and saliva samples received from patients suspected of malaria. Subsequently, malaria parasitaemia was determined. From the same patients, body temperature readings and haemoglobin concentrations were recorded. Also, micro-haematuria and saliva occult blood were determined. Relative to blood, the sensitivities and the performance of urine and saliva as alternative samples were evaluated. Results A total of 706 suspected malaria patients provided all three specimens. Prevalence of malaria by microscopy and RDT was 44.2% and 53.9%, respectively. Compared to blood, the sensitivities of urine and saliva were 35.2% and 57.0% respectively. Haemoglobin concentration < 9.9 g/dL, body temperature > 38.7 °C and occult blood influenced the detection of malaria antigens in both urine and saliva. Furthermore, the antigens were not detected in urine and saliva when parasitaemia was < 60,000 parasites/µL and < 40,000 parasites/µL, respectively. Conclusion Saliva, with or without blood contamination, was found to be more efficient that urine samples. Therefore these non-blood specimens have the potential to be used as non-invasive samples for malaria diagnosis. However, this approach is useful in severe to moderate anaemia, hyperthermia, parasitaemia > 60,000 parasites/µL and samples contaminated with blood.

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Section: Discussionsupporting

confidence: 60%

Evaluating the potential of using urine and saliva specimens for malaria diagnosis in suspected patients in Ghana

Aninagyei

Abraham

Atiiga

et al. 2020

Malar J

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“…Oral manifestations of many hematological diseases are clinically similar to locally occurring lesions. [10,11] For this reason, a specific diagnosis of blood dyscrasia is difficult, if not impossible, to establish on the basis of oral findings alone. The dentist may be the first health care professional to evaluate a patient with acute gingival bleeding owing to an underlying blood dyscrasia.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical history, systemic signs of a bleeding disorder, and abnormal tests for hemostasis may help the dentist in the early detection and referral of patients for further management. [10,12,13] Causes of acute severe diffuse gingival bleeding include local and nondental causes, which include vitamin deficiencies, malignancies, such as leukemia, side effects of certain medications, and occasionally systemic diseases. Hemorrhagic disorders in which abnormal gingival bleeding is encountered include vascular abnormalities (vitamin C deficiency or allergy, e.g., Henoch-Schönlein purpura), platelet disorders [14] (e.g., thrombocytopenic purpura), hypoprothrombinemia (vitamin K deficiency), other coagulation defects (e.g., hemophilia), deficient platelet thromboplastic factor (PF3) resulting from uremia, [15] multiple myeloma, [16] leukemia, [17] and postrubella purpura.…”

Section: Discussionmentioning

confidence: 99%

Severe hemorrhage in a patient with dengue hemorrhagic fever after insertion of orthodontic mini-implants. A case report

Pithon

2020

BDS

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The objective of this paper is to report a clinical case of a patient who after installing an orthodontic mini-implant returned to the dental office seven days later with a severe hemorrhage where it was inserted. Because of the severe character of the hemorrhage, the mini-implant was removed, local compression was performed, medication to control bleeding was given and some lab tests were requested. The patient returned in 24 hours with diagnosis of dengue hemorrhagic fever (DHF). The patient was referred to the specialized hematology service where the diagnosis was confirmed. Past the critical period, a new mini-implant was inserted to continue the orthodontic treatment. It can be concluded from this account that despite the mini-implants being devices of simple installation and easy removal, it is important that the patient's systemic conditions are optimal for their overall effectiveness. Keywords Dengue; Hemorrhage; Orthodontic Anchorage Procedures.

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“…Severe dengue infection has a tendency of developing haemorrhage involving blood hemolysis 63 , 64 and it is known that blood hemolysis contributes to the accumulation of serum ferritin as well as from damaged cells 65 . In addition, activated macrophages also secrete ferritin into plasma although its mechanism is still unknown 66 .…”

Section: Discussionmentioning

confidence: 99%

Macrophage Activation Syndrome-Associated Markers in Severe Dengue

Ab-Rahman¹,

Rahim²,

AbuBakar³

et al. 2016

Int. J. Med. Sci.

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Hemophagocytosis, a phenomenon of which activated macrophages phagocytosed hematopoietic elements was reportedly observed in severe dengue patients. In the present study, we investigated whether markers of macrophage activation syndrome (MAS) can be used as differential diagnostic markers of severe dengue. Two hundred and eight confirmed dengue patients were recruited for the study. Sandwich ELISA was used to determine serum ferritin, soluble CD163 (sCD163), and soluble CD25 (sCD25) levels. The population of circulating CD163 (mCD163) monocytes was determined using flow cytometry. Receiver operating characteristic (ROC) analysis was plotted to determine the predictive validity of the biomarkers. Serum ferritin and sCD163 were found significantly increased in severe dengue patients compared to dengue fever patients (P = 0.003). A fair area under ROC curves (AUC) at 0.72 with a significant P value of 0.004 was observed for sCD163. sCD25 and mCD163 levels were not significantly different between severe dengue and dengue fever patients. Our findings suggest that in addition to serum ferritin, sCD163 can differentiate severe dengue from that of dengue fever patients. Hence, sCD163 level can be considered for use as a predictive marker for impending severe dengue.

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Acute gingival bleeding as a complication of dengue hemorrhagic fever

Cited by 16 publications

References 11 publications

Evaluating the potential of using urine and saliva specimens for malaria diagnosis in suspected patients in Ghana

Evaluating the potential of using urine and saliva specimens for malaria diagnosis in suspected patients in Ghana

Severe hemorrhage in a patient with dengue hemorrhagic fever after insertion of orthodontic mini-implants. A case report

Macrophage Activation Syndrome-Associated Markers in Severe Dengue

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