Acute Generalized Varicella Zoster in the Setting of Preexisting Generalized Erythema

Egan, Conleth A.; O'Reilly, Margretta A.; Vanderhooft, Sheryll L.; Rallis, Tena M.

doi:10.1046/j.1525-1470.1999.00026.x

Cited by 7 publications

(6 citation statements)

References 13 publications

(10 reference statements)

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“…A very characteristic feature of varicella is the finding of lesions in all stages of development at one time in the same area. The diagnosis of varicella is usually made from this characteristic clinical presentation and may be confirmed by the finding of multinucleated giant cells on a Tzanck smear of cells scraped from the base of an early vesicle (9). The diagnosis of varicella in our patient was made from this characteristic clinical presentation and confirmed by a high VZV‐IgM titer in the serum.…”

Section: Discussionmentioning

confidence: 99%

Primary Varicella Infection Associated with Stevens-Johnson Syndrome in a Turkish Child

Bay

Akdeniz

Çalka

et al. 2005

The Journal of Dermatology

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Stevens-Johnson syndrome (SJS) is defined as a severe erythema-multiforme-like eruption of the skin and lesions of the oral, genital and anal mucosa and hemorrhagic crusting on the lips; it is associated with fever, headache, and arthralgia. The disease is a part of a continuum of immunologically mediated mucocutaneous diseases at various grades of severity. SJS is often induced by drugs, but the pathophysiologic mechanism is completely unknown. Patients and their first degree-relatives may have genetic defects in their metabolic pathways that lead to the accumulation of toxic metabolites. However, viral infections are known triggers of this skin disorder. Varicella zoster virus has been only very rarely reported as an etiological agent in SJS, despite its high incidence as a pathogen in childhood. In this study, we report a case of primary varicella infection associated with SJS because of its rare presentation. To the best of our knowledge, our case is the youngest child in the literature.

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Section: Discussionmentioning

confidence: 99%

Primary Varicella Infection Associated with Stevens-Johnson Syndrome in a Turkish Child

Bay

Akdeniz

Çalka

et al. 2005

The Journal of Dermatology

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“…Underlying dermatoses may modify the exanthem. Egan et al 5 . reported an acute generalized varicella with a pre‐existing scarlet fever generalized erythema.…”

Section: Discussionmentioning

confidence: 99%

“…Atypical varicella has been associated with immunosuppression, 2 skin injury, 3 sun exposure 4 and pre‐existing cutaneous disease 5 …”

Section: Discussionmentioning

confidence: 99%

Atypical varicella with palm and sole involvement

Auvin¹,

Catteau²,

Ganga‐Zandzou³

et al. 2002

Int J Dermatology

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Varicella is a common disease characterized by a typical presentation. We report a case of an atypical presentation of varicella with a centrifugal distribution, eruption with many vesicles, no pustular stage in evolution and distal involvement. There were none of the known modifying factors (immunosuppression, skin disease, injury or sun exposure). To explain the distal involvement we suggest intraepidermic lesions caused by a pre-existing B1 coxsackie infection.

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“…The clinical diagnosis of primary varicella was supported by history of recent exposure to varicella and absence of prior varicella in all cases, by a Tzanck smear in 21 cases and by a positive test for varicella zoster virus in 7 cases. Twentyfour cases were photo-localised [8][9][10][11][12][13][14][15][16][17][18]20,21,23,24,28,30,31,33,38,41,43 and 35 6,7,14,16,19,21,22,[25][26][27]29,30,32,[34][35][36][37]40,42 skin inflammation associated. Females (79%) predominated in the cases with photo-localised varicella, males (57%) in the group with skin inflammation-associated varicella (p < 0.01).…”

Section: Clinical Datamentioning

confidence: 99%

“…The study flowchart is shown in Figure 1. For the final analysis, we retained 38 communications published between 1927 and 2021 in English ( N = 33), French ( N = 3) or Spanish ( N = 2) 6–43 …”

Section: Synthesismentioning

confidence: 99%

Atypical primary varicella rash: Systematic literature review

et al. 2022

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Aim In previously healthy subjects, primary varicella presents with a distinctive vesicular rash that is more intense on the trunk and head than on the extremities. However, an atypical presentation may occasionally develop. We aimed at systematically assessing the characteristics of cases affected by atypical primary varicella rash. Methods The United States National Library of Medicine, Excerpta Medica and Web of Science databases were reviewed, without date or language restrictions. Articles were eligible if reporting previously healthy and immunocompetent subjects with a primary varicella rash (i.e., a photo‐localised primary varicella or skin inflammation‐associated primary varicella). Results Thirty‐eight reports providing information on 59 cases of atypical primary varicella were identified. Twenty‐four cases (median 8.5 years of age, 19 females) were photo‐localised and 35 (median 4.8 years of age, 15 females) were associated with pre‐existing skin inflammation (including cast occlusion, diaper irritation, operative sites, burns, insect bites, vaccinations or pre‐existing skin disease). The skin rash was monomorphic and without a “starry sky” appearance. Conclusion Primary varicella may have a modified presentation in areas of irritation such as sun exposure or pre‐existing inflammation. There is a need for a wider awareness of these modulators of varicella rash.

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Acute Generalized Varicella Zoster in the Setting of Preexisting Generalized Erythema

Cited by 7 publications

References 13 publications

Primary Varicella Infection Associated with Stevens-Johnson Syndrome in a Turkish Child

Primary Varicella Infection Associated with Stevens-Johnson Syndrome in a Turkish Child

Atypical varicella with palm and sole involvement

Atypical primary varicella rash: Systematic literature review

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