Acute Generalized Exanthematous Pustulosis Simulating Toxic Epidermal Necrolysis: Overlapping Processes

Abellán, J. García; Català, J.; Larrieu, A. Jaén; Ramírez, I. Valencia

doi:10.1016/j.adengl.2018.04.017

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2020

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“…A literature search using PubMed and OVID with the terms "AGEP," "acute generalized exanthemous pustulosis," and "TMP-SMX," "trimethoprim," or "sulfamethoxazole" from the years 1990-2020 returned 10 separate cases: most involved polypharmacy (9/10), 1/10 was not biopsy-confirmed, and 4/10 were immunocompromised with complicated disease courses including: chemotherapy for treatment of glioblastoma, Burkitt's lymphoma, chronic myelogenous leukemia status post stem cell transplant, and AIDS with a disseminated multidrug-resistant tuberculosis infection [4,[8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis in an African American Male Caused by Trimethoprim-Sulfamethoxazole

Bressler

Minkowitz

Pathak

et al. 2020

Cureus

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Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced autoimmune disease that presents with hundreds of sterile pustules and systemic symptoms. Genetic predisposition, race, and medications prescribed are all factors in AGEP's frequency, which occurs most commonly in Caucasians and with the use of macrolides and aminopenicillins. Cases of AGEP with sulfonamides or in African American patients are rare. To our knowledge, this is the first documented example of trimethoprim-sulfamethoxazole-induced AGEP in an African American male. In this article, we will further discuss our case and review the literature.

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