Acute Generalized Exanthematic Pustulosis Induced by Cefaclor and Acetazolamide

Ogoshi, Machiko; Yamada, Yuji; Tani, Masanao

doi:10.1159/000247524

Cited by 32 publications

(15 citation statements)

References 2 publications

(3 reference statements)

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“…There are only two reports on positive-Dl.ST in AGEP (4, 5); negative results have been reported by several authors (3,7,8). Triibe and Burg reported a case of AGEP due to doxycycline, in which DLST showed a very high stimulating index of 13 (5).…”

Section: Discussionmentioning

confidence: 83%

“…While provocation tests are most reliable for identifying the causative drugs, they are sometimes potentially dangerous. In AGEP, the diagnosis of drug eruption is occasionally made by programmed or accidental provocation tests (2)(3)(4)(5). Both patch tests and drug lymphocyte stimulation tests (DLST) have been useful in correlating a specific drug with AGEP (2,(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Drug Induced Acute Generalized Exanthematous Pustulosis

Katagiri¹,

Takayasu²

1996

The Journal of Dermatology

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A 62-year-old woman with diabetic triopathy developed widespread erythematous macules, numerous pustules, and a high fever after she underwent electric coagulation for vitreous hemorrhage. She was administered several drugs at that time. After discontinuation of the drugs, the eruption disappeared, and the fever returned to normal within two weeks. A positive patch test with isepamicin sulfate highly suggested that the symptoms described above were due to drug allergy. Cadralazine, which was positive in the drug lymphocyte stimulation test (DLST), could not be excluded from the causative drugs. A false-positive DLST with ofloxacin was confirmed by an accidental challenge test. To our knowledge, this is the first report of acute generalized exanthematous pustulosis due to isepamicin sulfate and/or cadralazine.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Drug Induced Acute Generalized Exanthematous Pustulosis

Katagiri¹,

Takayasu²

1996

The Journal of Dermatology

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“…Only a few cases of CADR with oral acetazolamide have been previously reported [5,6,7](table 3). All these cases were severe CADR (AGEP, Stevens-Johnson syndrome).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reaction to Oral Acetazolamide and Skin Tests

Bellon¹,

Assier²,

Amsler³

et al. 2013

Dermatology

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Background: Few cases of cutaneous adverse drug reactions (CADR) to oral acetazolamide, a non-antimicrobial sulfonamide, have been previously reported, and the interest of acetazolamide skin tests has never been studied. Objectives: We report a series of ten patients with oral acetazolamide CADR and skin tests. Patients and Methods: The files of ten patients with CADR secondary to oral acetazolamide prescribed for cataract surgery in most cases referred between 2001 and 2011 in four French dermatology and allergy departments were retrospectively reviewed. Skin tests with acetazolamide were performed in nine patients and twelve controls. Other sulfonamides were tested in five of ten patients. Results: Seven patients developed maculopapular exanthema and four had acute generalized exanthematous pustulosis. Patch tests were positive for 8/9 patients, prick tests for 2/4 and intradermal tests for 3/3. Patch and prick or intradermal test results were concordant in 2/3 positive subjects. Patch tests for other sulfonamides were negative, as were patch tests in controls. Conclusions: We report the largest series of CADR to oral acetazolamide (maculopapular exanthema or acute generalized exanthematous pustulosis). A drug eruption after cataract surgery should be investigated for accountability of acetazolamide. In view of this retrospective study, skin tests and particularly intradermal tests appear to be an important contribution to demonstrate accountability.

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“…It is widely used in the treatment for glaucoma and is also recommended for the prophylaxis of acute mountain sickness (3). Recently Ogoshi et al (4) reported a case of an acute generalized exanthematic pustulosis (AGEP), which occurred following administration of acetazolamide for glaucoma. The pustular eruptions precipitated by acetazolamide in our case may be atypical, because they had no relationship to preexisting psoriatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Pustular Psoriasis Precipitated by Acetazolamide

Kuroda

Kojima

Tanabe

et al. 1995

The Journal of Dermatology

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We report a case of pustular psoriasis precipitated by acetazolamide, a carbonic anhydrase inhibitor. A 28-year-old man suffering from 20 years-standing generalized pustular psoriasis developed psoriatic arthritis and glaucoma and experienced a precipitation of pustular lesions and widespread erythema after initiation of oral acetazolamide for glaucoma. The cutaneous lesions and systemic symptoms improved after restriction of acetazolamide and administration of oral etretinate. Readministration of acetazolamide confirmed that generalized pustules arose within 24 hours.

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Acute Generalized Exanthematic Pustulosis Induced by Cefaclor and Acetazolamide

Abstract: We report a case of acute generalized exanthematic pustulosis induced by 2 different drugs, cefaclor and acetazolamide. The diagnosis was confirmed by challenge tests, and these 2 drugs respectively were proven to be responsible for the patient’s pustular eruptions.

Cited by 32 publications

References 2 publications

Drug Induced Acute Generalized Exanthematous Pustulosis

Drug Induced Acute Generalized Exanthematous Pustulosis

Cutaneous Adverse Drug Reaction to Oral Acetazolamide and Skin Tests

Pustular Psoriasis Precipitated by Acetazolamide

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