Acute gastroenteritis in a pediatric population from Cali, Colombia in the post rotavirus vaccine era

López‐Medina, Eduardo; Parra, Beatriz; Dávalos, Diana; López, Pío; Villamarin, Eder; Pelaez, Melissa

doi:10.1016/j.ijid.2018.06.006

Cited by 13 publications

(12 citation statements)

References 36 publications

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“…DEC was identified in 609 (5.0%) of these samples. A similar study found DEC in 7.44% of cases in children under 5 years of age [10], whilst a small study found it in 6/155 (3.9%) of single infections using a molecular gastrointestinal panel [11]. We previously demonstrated the concurrent circulation of all DEC pathotypes and a predominance of EPEC and EIEC in a study from 2005 to 2007 [3].…”

Section: Discussionmentioning

confidence: 97%

Diarrheagenic Escherichia coli in Costa Rican children: a 9-year retrospective study

Pérez-Corrales

Leandro-Sandí

2019

BMC Res Notes

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Objectives This study aimed to estimate diarrheagenic Escherichia coli (DEC) prevalence among pediatric patients with diarrhea at the Costa Rican National Children’s Hospital-Social Security Service (Hospital Nacional de Niños-Caja Costarricense del Seguro Social; HNN-CCSS). DEC variations with respect to rainfall, presence of coinfections, and DEC antimicrobial resistance were also investigated. Results A retrospective observational study from January 2008 to December 2016 was conducted. A total of 12 247 gastroenteritis records were analyzed. Annual DEC prevalence ranged from 2.7% (2008) to 9.0% (2013). The most prevalent pathotypes were enteroaggregative E. coli (EAEC) [n = 189 (31%)], enteropathogenic E. coli (EPEC) [n = 145 (24%)] and enteroinvasive E . coli (EIEC) [n = 91 (15%)]. A reduction in the probability of EAEC gastroenteritis was detected as rainfall rose above 200 mm/mo. [(Generalized Additive Model (GAM), p = 0.04)]. Coinfections were observed mainly between EPEC and Campylobacter spp. (10%). Antimicrobial resistance occurred in 0.6%, 29%, and 42% of DEC for ciprofloxacin, trimethoprim/sulfamethoxazole, and ampicillin, respectively.

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Section: Discussionmentioning

confidence: 97%

Diarrheagenic Escherichia coli in Costa Rican children: a 9-year retrospective study

Pérez-Corrales

Leandro-Sandí

2019

BMC Res Notes

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“…33 In Colombia, rotavirus remained the leading cause of gastroenteritis found in 33.7% of children less than 5 y of age hospitalized for acute gastroenteritis, with norovirus being found in 22.6% of the patients. 21 A study from the United States 6 during the universal rotavirus immunization years showed that norovirus was detected in 21% of children seeking medical care for gastroenteritis, compared to only 12% for rotavirus. Our findings together with others' 21,22,[32][33][34] suggest that norovirus is a leading cause of gastroenteritis associated with seeking medical care and hospitalizations in young children, regardless of the introduction of the universal rotavirus immunization program.…”

Section: Discussionmentioning

confidence: 99%

“…21 A study from the United States 6 during the universal rotavirus immunization years showed that norovirus was detected in 21% of children seeking medical care for gastroenteritis, compared to only 12% for rotavirus. Our findings together with others' 21,22,[32][33][34] suggest that norovirus is a leading cause of gastroenteritis associated with seeking medical care and hospitalizations in young children, regardless of the introduction of the universal rotavirus immunization program. Despite the challenges facing the development of a norovirus vaccine, 23 prevention of norovirus gastroenteritis through vaccination is especially attractive in view of the success of rotavirus immunization in preventing rotavirus gastroenteritis and child mortality due to diarrheal diseases globally.…”

Section: Discussionmentioning

confidence: 99%

“…6 However such differences were not noted in other countries. 21,22 Given advances in the development of norovirus vaccines, 23,24 understanding the epidemiological characteristics of norovirus gastroenteritis becomes an important public health need. The study aim was to examine the incidence and characteristics of norovirus gastroenteritis among children in Israel.…”

Section: Introductionmentioning

confidence: 99%

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No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel

Muhsen

Kassem

Rubenstein

et al. 2019

Human Vaccines & Immunotherapeutics

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Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Israel. We studied 1179 stool samples collected between November 2007 and December 2014 for a prospective hospital-based surveillance study of children aged 0-59 months hospitalized for gastroenteritis. A real-time RT-PCR assay was used to identify genogroup II (GII) norovirus in extracted fecal RNA samples. Overall, the weighted percentage of norovirus positive patients was 10.9%. Norovirus positivity was similar in the pre-universal rotavirus immunisation years (2008-2010) and the universal years (2011-2014), the respective average annual incidence of norovirus gastroenteritis was 1.6 (95% CI 0.6-2.3) per 1000 and 1.1 (95% CI 0.8-1.4) per 1000 children. Rotavirus was detected in 36.8% and 19.6% of the patients in the pre-vaccine years and the universal vaccine years, with an estimated incidence of 5.5 (95% CI 3.4-7.6) per 1000 and 2.1 (95% CI 1.6-2.7) per 1000 children, respectively. Most patients (59.1%) with norovirus gastroenteritis were infants aged 0-11 months. Norovirus was detected all year round with a significant 3-month peak from September through November. In conclusion, norovirus continues to be a leading cause of acute gastroenteritis associated with hospitalizations in young children. Future norovirus vaccines should target young infants. There was no evidence of pathogen-replacement by norovirus following the introduction of universal rotavirus immunization in Israel.

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“…Colombia, a middle-income country in Latin America, has an estimated risk of AGE of 2.5% in children less than 5 years of age and risk of 2.0% in less than 10 years of age [ 7 ]. Studies reported that rotavirus remains a leading cause of AGE in Colombia together with norovirus, with a reduced hospitalization rate, thanks to the introduction of monovalent rotavirus vaccine in Colombia in 2009 [ 8 – 10 ]. Studies on E .…”

Section: Introductionmentioning

confidence: 99%

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

Farfán-García¹,

Imdad

Zhang

et al. 2020

PLoS Negl Trop Dis

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Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low-and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/Principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10-18%)

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Acute gastroenteritis in a pediatric population from Cali, Colombia in the post rotavirus vaccine era

Cited by 13 publications

References 36 publications

Diarrheagenic Escherichia coli in Costa Rican children: a 9-year retrospective study

Diarrheagenic Escherichia coli in Costa Rican children: a 9-year retrospective study

No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

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