“…EDTA and the other polyaminocarboxylic acids are used in the treatment of poisoning due to a number of metals, including cadmium (19), iron (20,21), and manganese (22). These chelating agents are the treatment of choice for lead poisoning in the United States.…”
“…EDTA and the other polyaminocarboxylic acids are used in the treatment of poisoning due to a number of metals, including cadmium (19), iron (20,21), and manganese (22). These chelating agents are the treatment of choice for lead poisoning in the United States.…”
“…There have been reports on the use of EDTA in this connection, both in animal experiments and also in accidental iron poisoning in children (24,25 (7) indicate that tissue iron becomes available to chelates only when an excess is present. The rate of plasma iron turnover did not correlate with the amount of iron excreted after administration of chelate.…”
Section: Competitive Binding Of Iron Between Syntheticmentioning
“…(7) In the past, it has also been used in both the oral and intravenous form to treat iron ingestions but was never systematically studied. (8,9) We proposed to employ the chelator calcium disodium edetate as an oral solution with and without charcoal in a human crossover study of the ingestion of 5 mg/kg of elemental iron to see if it reduced iron absorption.…”
Orally administered EDTA did not significantly reduce iron absorption when administered 1 hour post iron ingestion during the 12 or 24-hour period following the ingestion of 5 mg/kg of elemental iron in healthy human volunteers.
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